公开(公告)号：US07820807B2

公开(公告)日：2010-10-26

申请号：US12420481

申请日：2009-04-08

Applicant: David Thomas ,  Mark De Boer ,  Pieter C. J. M. Res ,  Peter J. Simons

Inventor： David Thomas ,  Mark De Boer ,  Pieter C. J. M. Res ,  Peter J. Simons

IPC: C12N15/13 ,  C12N15/12 ,  C12N5/10

CPC classification number: A61K39/39541 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/2818 ,  C07K16/2878 ,  C07K2317/31 ,  A61K2300/00

Abstract: Disclosed are agonist anti-CD40 molecules, including monoclonal antibodies, which can bind to and stimulate professional and non-professional human antigen-presenting cells (“APCs”), enhance the stimulatory effect of CD40L on CD40 positive cells and/or induce phenotypical maturation of monocyte derived dendritic cells. Several such monoclonal antibodies are provided, and cell lines producing them have been deposited at the American Type Culture Collection.

Abstract translation: 公开了可以结合并刺激专业和非专业人抗原呈递细胞（“APC”）的激动剂抗CD40分子，包括单克隆抗体，增强CD40L对CD40阳性细胞的刺激作用和/或诱导表型成熟 的单核细胞来源的树突状细胞。 提供了几种这样的单克隆抗体，并且生产它们的细胞系已经保藏在美国典型培养物保藏中心。

公开(公告)号：US20090311268A1

公开(公告)日：2009-12-17

申请号：US12420481

申请日：2009-04-08

Applicant: David Thomas ,  Mark de Boer ,  Pieter C.J.M. Res ,  Peter J. Simons

Inventor： David Thomas ,  Mark de Boer ,  Pieter C.J.M. Res ,  Peter J. Simons

IPC: A61K39/395 ,  C07K16/00 ,  C07K16/28 ,  C07H21/04 ,  C12N5/10

CPC classification number: A61K39/39541 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/2818 ,  C07K16/2878 ,  C07K2317/31 ,  A61K2300/00

Abstract: Disclosed are agonist anti-CD40 molecules, including monoclonal antibodies, which can bind to and stimulate professional and non-professional human antigen-presenting cells (“APCs”), enhance the stimulatory effect of CD40L on CD40 positive cells and/or induce phenotypical maturation of monocyte derived dendritic cells. Several such monoclonal antibodies are provided, and cell lines producing them have been deposited at the American Type Culture Collection.

Abstract translation: 公开了可以结合并刺激专业和非专业人抗原呈递细胞（“APC”）的激动剂抗CD40分子，包括单克隆抗体，增强CD40L对CD40阳性细胞的刺激作用和/或诱导表型成熟 的单核细胞来源的树突状细胞。 提供了几种这样的单克隆抗体，并且生产它们的细胞系已经保藏在美国典型培养物保藏中心。

公开(公告)号：US07172759B2

公开(公告)日：2007-02-06

申请号：US09773866

申请日：2001-02-01

Applicant: David Thomas ,  Mark de Boer ,  Pieter C. J. M. Res ,  Peter J. Simons

Inventor： David Thomas ,  Mark de Boer ,  Pieter C. J. M. Res ,  Peter J. Simons

IPC: A61K39/395 ,  C07K16/28

CPC classification number: A61K39/39541 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/2818 ,  C07K16/2878 ,  C07K2317/31 ,  A61K2300/00

Abstract: Disclosed are methods of inducing maturation of antigen presenting cells and cytotoxic T lymphocyte responses utilizing agonist anti-CD40 antibodies that do not block the binding of CD40L to CD40.

Abstract translation: 公开了使用不阻断CD40L与CD40的结合的激动剂抗CD40抗体诱导抗原呈递细胞成熟的细胞毒性T淋巴细胞应答的方法。

公开(公告)号：US06230143B1

公开(公告)日：2001-05-08

申请号：US09189548

申请日：1998-11-11

Applicant: Peter J. Simons ,  Andrew F. Bennett ,  Glenn S. Morgan ,  William J. Ray

Inventor： Peter J. Simons ,  Andrew F. Bennett ,  Glenn S. Morgan ,  William J. Ray

IPC: G06F1760

CPC classification number: G06Q30/02 ,  G06Q30/0224 ,  G06Q30/0238 ,  G06Q30/0239

Abstract: A system and method for analyzing coupon redemption data, includes a parallel adaptive, self-arborizing network having a database component with a database containing consumer and client information, an extract module program that retrieves information from the database based on a set of user or computer designed criteria, an editor program which formats the information extracted from the database to be generated on a coupon or flyer to create a data template including at least one two dimensional bar code containing consumer and coupon information from the database, and a printing tool for encoding the data template on a coupon page. The system further includes a data recovery system, including at least one scanning device provided at the point of sale terminal adapted to read the two dimensional bar codes on the coupons and a store and forward system that stores the data collected by the scanning device at the point of sale terminal. The data redemption system includes a data accumulator that retrieves redeemed coupon information from the store and forward system in the retail client's store, which is transferred to a database analysis component of the parallel adaptive network via an Internet or similar modem communications transfer. The database analysis component of the parallel adaptive network analyzes the consumer and client information from the redeemed coupon data to determine consumer purchasing trends. The database analysis component learns from the analysis of consumer purchasing trends to define a modified set of coupon printing criteria based on the analysis.

Abstract translation: 一种用于分析优惠券兑换数据的系统和方法，包括具有包含消费者和客户信息的数据库的数据库组件的并行自适应自组网网络，提取模块程序，其基于一组用户或计算机从数据库中检索信息 设计标准，编辑程序，其格式化从数据库提取的信息，以在优惠券或传单上生成，以创建包含至少一个二维条形码的数据模板，该二维条形码包含来自数据库的消费者和优惠券信息，以及用于编码的打印工具 优惠券页面上的数据模板。 该系统还包括数据恢复系统，其包括设置在销售点终端处的适于读取优惠券上的二维条形码的至少一个扫描装置，以及存储和转发系统，该存储和转发系统将由扫描装置收集的数据存储在 销售点终端。 数据兑换系统包括数据累加器，该数据累加器从零售客户端存储中的存储和转发系统中检索兑换的优惠券信息，该系统经由互联网或类似的调制解调器通信传送被传送到并行自适应网络的数据库分析组件。 并行自适应网络的数据库分析组件从兑换的优惠券数据中分析消费者和客户信息，以确定消费者的购买趋势。 数据库分析组件从消费者购买趋势的分析中学习，以基于分析定义一组修改的优惠券打印标准。