Abstract:
Disclosed are agonist anti-CD40 molecules, including monoclonal antibodies, which can bind to and stimulate professional and non-professional human antigen-presenting cells (“APCs”), enhance the stimulatory effect of CD40L on CD40 positive cells and/or induce phenotypical maturation of monocyte derived dendritic cells. Several such monoclonal antibodies are provided, and cell lines producing them have been deposited at the American Type Culture Collection.
Abstract:
Disclosed are agonist anti-CD40 molecules, including monoclonal antibodies, which can bind to and stimulate professional and non-professional human antigen-presenting cells (“APCs”), enhance the stimulatory effect of CD40L on CD40 positive cells and/or induce phenotypical maturation of monocyte derived dendritic cells. Several such monoclonal antibodies are provided, and cell lines producing them have been deposited at the American Type Culture Collection.
Abstract:
Disclosed are methods of inducing maturation of antigen presenting cells and cytotoxic T lymphocyte responses utilizing agonist anti-CD40 antibodies that do not block the binding of CD40L to CD40.
Abstract:
A system and method for analyzing coupon redemption data, includes a parallel adaptive, self-arborizing network having a database component with a database containing consumer and client information, an extract module program that retrieves information from the database based on a set of user or computer designed criteria, an editor program which formats the information extracted from the database to be generated on a coupon or flyer to create a data template including at least one two dimensional bar code containing consumer and coupon information from the database, and a printing tool for encoding the data template on a coupon page. The system further includes a data recovery system, including at least one scanning device provided at the point of sale terminal adapted to read the two dimensional bar codes on the coupons and a store and forward system that stores the data collected by the scanning device at the point of sale terminal. The data redemption system includes a data accumulator that retrieves redeemed coupon information from the store and forward system in the retail client's store, which is transferred to a database analysis component of the parallel adaptive network via an Internet or similar modem communications transfer. The database analysis component of the parallel adaptive network analyzes the consumer and client information from the redeemed coupon data to determine consumer purchasing trends. The database analysis component learns from the analysis of consumer purchasing trends to define a modified set of coupon printing criteria based on the analysis.