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公开(公告)号：US08012950B2
公开(公告)日：2011-09-06
申请号：US10929919
申请日：2004-08-30
IPC分类号： A61K31/519 , A61K31/65
CPC分类号： C12Q1/6883 , C12Q2600/158 , G01N33/573 , G01N33/6887 , G01N2333/916 , G01N2333/96466 , G01N2800/102
摘要： Disclosed are methods for detecting and treating joint disease. The methods of diagnosis include determining increased expression of enzymes that are upregulated during the progress of joint and ligament inflammation and degeneration. In addition, disclosed are methods of treating the disease including inhibiting the activity of responsible proteases.
摘要翻译： 公开了检测和治疗关节疾病的方法。 诊断方法包括确定在关节和韧带炎症和退行进展期间上调的酶的增加的表达。 此外，公开了治疗疾病的方法，包括抑制负责任的蛋白酶的活性。
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2.发明申请Methods of diagnosing synovial disease in a mammal by detecting bacterial DNA in synovial tissues from dogs with inflammatory knee arthritis and degenerative anterior cruciate ligament rupture 审中-公开通过检测来自具有炎性膝关节炎和退行性前十字韧带断裂的狗的滑膜组织中的细菌DNA来诊断哺乳动物滑膜疾病的方法公开(公告)号：US20080045485A1
公开(公告)日：2008-02-21
申请号：US11893740
申请日：2007-08-17
申请人： Peter Muir
发明人： Peter Muir
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/158 , G01N2800/10 , G01N2800/102 , Y02A50/57 , Y10T436/143333
摘要： Method of diagnosing persistent, chronic synovitis and progressive joint degradation in the joint of a mammal. The method including providing a test sample comprising synovial fluid, cell or tissue from the joint of a mammal; detecting the presence of bacterial DNA, measuring the concentration of one or more biomarkers being cathepsin K, MMP-2 and -9, cathepsin S, tartrate-resistant acid phosphatase, invariant chain, CD4+ T-lymphocytes, CD8+ T-lymphocytes, CD44+ mononuclear cells, Toll-like receptor-2, Toll-like receptor-9, or a combination thereof; and, comparing the concentration of the biomarker from the test sample to a corresponding biomarker concentration in a control sample from healthy dogs, or an internal PBMC control sample, wherein a statistically significant elevated concentration of the biomarker in the test sample indicates that the mammal's joint is diseased.
摘要翻译： 在哺乳动物的关节中诊断持续性，慢性滑膜炎和进行性关节退化的方法。 该方法包括从哺乳动物的关节提供包含滑液，细胞或组织的测试样品; 检测细菌DNA的存在，测量作为组织蛋白酶K，MMP-2和-9的组织蛋白酶S，酒石酸抗性酸性磷酸酶，不变链，CD4 + T淋巴细胞的一种或多种生物标志物的浓度 ，CD8 + + T细胞，CD44 +单核细胞，Toll样受体-2，Toll样受体-9或其组合; 并且将来自测试样品的生物标志物的浓度与来自健康狗或内部PBMC对照样品的对照样品中相应的生物标志物浓度进行比较，其中测试样品中生物标志物的统计学显着升高浓度表明哺乳动物的关节 是患病的
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公开(公告)号：US20050074800A1
公开(公告)日：2005-04-07
申请号：US10929919
申请日：2004-08-30
申请人： Peter Muir , Ray Vanderby , Paolo Provenzano
发明人： Peter Muir , Ray Vanderby , Paolo Provenzano
IPC分类号： C12Q1/68 , G01N33/573 , G01N33/68 , C12Q1/37
CPC分类号： C12Q1/6883 , C12Q2600/158 , G01N33/573 , G01N33/6887 , G01N2333/916 , G01N2333/96466 , G01N2800/102
摘要： Disclosed are methods for detecting and treating joint disease. The methods of diagnosis include determining increased expression of enzymes that are upregulated during the progress of joint and ligament inflammation and degeneration. In addition, disclosed are methods of treating the disease including inhibiting the activity of responsible proteases.
摘要翻译： 公开了检测和治疗关节疾病的方法。 诊断方法包括确定在关节和韧带炎症和退行进展期间上调的酶的增加的表达。 此外，公开了治疗疾病的方法，包括抑制负责任的蛋白酶的活性。
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