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公开(公告)号:US20190219572A1
公开(公告)日:2019-07-18
申请号:US16359142
申请日:2019-03-20
申请人: Abaxis, Inc.
IPC分类号: G01N33/543 , G01N33/68 , G01N33/558 , G01N33/569 , G01N33/58
CPC分类号: G01N33/54393 , G01N33/54306 , G01N33/54313 , G01N33/54386 , G01N33/558 , G01N33/56911 , G01N33/56983 , G01N33/587 , G01N33/6854 , G01N33/6857 , G01N33/6893 , G01N2333/20 , G01N2333/29 , G01N2469/20 , Y02A50/57
摘要: The present invention provides methods, devices, compositions (e.g., capture complexes), and kits useful for enhancing the detection of antibodies in a test sample. The methods, devices, and compositions utilize detectable Fc-binding molecules such as Protein A, Protein G, and/or an Fc-specific antibody to amplify the signal of a detected antibody in immunoassays, such as lateral flow assays.
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公开(公告)号:US20190178893A1
公开(公告)日:2019-06-13
申请号:US16058316
申请日:2018-08-08
发明人: John N. Aucott , Mark J. Soloski
CPC分类号: G01N33/6863 , A61K31/43 , A61K31/65 , G01N2333/43556 , G01N2333/521 , G01N2800/26 , G01N2800/52 , G01N2800/56 , Y02A50/401 , Y02A50/57
摘要: The present invention relates to the field of Lyme disease. More specifically, the present invention provides methods and composition useful for the treatment of Lyme disease. In one aspect, the present invention provides compositions and methods for treating a patient at risk for or likely to develop post-treatment Lyme disease syndrome (PTLDS). In certain embodiments, the patient is already undergoing a first course of antibiotic treatment for Lyme disease. In a specific embodiment, a method comprises the step of prescribing or administering a second course of antibiotic treatment to a patient who is determined to have an increased level of CCL19 as compared to a control after completing a first course of antibiotics for Lyme disease.
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公开(公告)号:US20180267056A1
公开(公告)日:2018-09-20
申请号:US15991982
申请日:2018-05-29
申请人: SERIMMUNE INC.
IPC分类号: G01N33/68
CPC分类号: G01N33/6854 , C07K14/195 , C07K14/285 , C07K14/315 , C07K14/43554 , C07K14/44 , C07K14/45 , C12N15/1037 , C12Q1/689 , G01N33/6842 , G01N2800/26 , Y02A50/57
摘要: The present invention provides compositions and methods that can be used to determine a peptide signature for an antibody repertoire in a sample comprising multiple antibodies. The method can be used to characterize a phenotype in a sample, such as providing a diagnosis, prognosis or theranosis of a medical condition.
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公开(公告)号:US10073095B2
公开(公告)日:2018-09-11
申请号:US15684635
申请日:2017-08-23
申请人: ABAXIS, INC.
IPC分类号: A61K39/00 , A61K39/02 , A61K39/38 , G01N33/569 , C07K14/20
CPC分类号: G01N33/56911 , C07K14/20 , G01N2333/20 , G01N2469/20 , Y02A50/57
摘要: The invention provides compositions (e.g., peptide compositions) useful for the detection of antibodies that bind to Borrelia antigens. The peptide compositions comprise polypeptide sequences comprising variants in the IR6 domain of the Borrelia VlsE protein. The invention also provides devices, methods, and kits comprising such peptide compositions and useful for the detection of antibodies that bind to Borrelia antigens and the diagnosis of Lyme disease.
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5.
公开(公告)号:US20180251818A1
公开(公告)日:2018-09-06
申请号:US15983209
申请日:2018-05-18
IPC分类号: C12Q1/6806 , C12Q1/6837 , C12Q1/6876
CPC分类号: C12Q1/6806 , C12Q1/6837 , C12Q1/6876 , C12Q2600/158 , C12Q2600/16 , Y02A50/57
摘要: The present invention generally relates to a set of early developmental reference data or “lineage scorecard” for stem cells, and methods, systems and kits to generate a lineage scorecard for predicting the functionality and suitability of stem cell lines. In some aspects, methods for generating a scorecard comprises measuring the gene expression of a plurality of early developmental genes, such as pluripotent, early ectoderm, early mesoderm and early endoderm genes to predict the pluripotency and differentiation potential of the stem cell line and its functionality and/or suitability for a desired use. In some embodiments, a reference scorecard can be compared with the test stem cell line scorecard to accurately predict the utility and/or identify specific characteristics of the stem cell line, e.g., to determine its suitability for downstream applications, e.g., therapeutic use, drug screening, toxicity assays, differentiation into a desired cell lineage, etc.
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公开(公告)号:US20180238902A1
公开(公告)日:2018-08-23
申请号:US15805437
申请日:2017-11-07
发明人: Ram S. Bhatt , Rishi Bhatt
IPC分类号: G01N33/68 , G01N33/569 , G01N33/574
CPC分类号: G01N33/6857 , C07K2317/20 , C07K2317/22 , C07K2317/569 , G01N33/56966 , G01N33/574 , G01N33/6893 , G01N2800/387 , Y02A50/57 , Y02A50/58 , Y02A50/59
摘要: Camelid and shark single-domain heavy chain antibodies lacking the light chains, and their analogs are disclosed. Methods for using the antibodies and their analogs to detect antigens are disclosed. Methods to derivatize such antibodies and analogs to develop diagnostic assays are described. Also provided are kits, and methods of using such diagnostics assays.
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公开(公告)号:US10006912B2
公开(公告)日:2018-06-26
申请号:US15102002
申请日:2014-12-08
申请人: BIOPEPTIDES CORP.
IPC分类号: A61K39/02 , C07K14/00 , G01N33/569 , C07K14/20
CPC分类号: G01N33/56911 , C07K14/20 , G01N2333/20 , G01N2469/20 , G01N2800/26 , Y02A50/57
摘要: The present invention relates, e.g., to a composition comprising peptides represented by SEQ ID NO:1, or active variants thereof, wherein the peptides or active variants can bind specifically to an antibody induced by a causative agent of Lyme disease (a pathogenic Borrelia), e.g. in a sample from a subject having Lyme disease. Compositions of the invention may comprise multiple peptides, from multiple proteins. Diagnostic kits comprising the peptides are described, as are diagnostic assays using the peptides.
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公开(公告)号:US09977020B2
公开(公告)日:2018-05-22
申请号:US15019520
申请日:2016-02-09
申请人: BIOMERIEUX
IPC分类号: G01N33/569 , C07K14/20 , C07K16/42
CPC分类号: G01N33/56911 , A61K39/00 , C07K14/195 , C07K14/20 , C07K16/4233 , C07K2319/40 , G01N2333/20 , G01N2469/20 , Y02A50/401 , Y02A50/57
摘要: Chimera proteins including: (i) at least one sequence of a DbpA protein of a Borrelia species selected from B. afzelii, B. burgdorferi sensu stricto and B. garinii, and (ii) at least one sequence of an OspC protein of a Borrelia species selected from B. afzelii, B. burgdorferi sensu stricto and B. garinii. Also, a method and a kit for the in vitro diagnosis of Lyme borreliosis using said proteins.
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公开(公告)号:US20180106804A1
公开(公告)日:2018-04-19
申请号:US15786191
申请日:2017-10-17
IPC分类号: G01N33/569 , G06T7/00 , G06K9/32 , G01N35/00 , G01N33/543 , G01N33/68 , G01N33/558
CPC分类号: G01N33/56983 , G01N15/0612 , G01N33/54366 , G01N33/558 , G01N33/689 , G01N33/6893 , G01N33/76 , G06K9/3216 , G06T7/0012 , G06T7/0014 , G06T7/33 , G06T2207/10024 , G06T2207/30072 , Y02A50/57
摘要: An immediate health assessment response system, comprising a testing device having thereon an alignment target and having a plurality of immunoassay test strips, the plurality of immunoassay test strips each including a sample pad capable of receiving a biologic sample, and a server configured to receive information from a mobile device regarding test results from a test performed using the testing device, receive an image from a mobile device, process the image to determine results based on pixel count and line intensity of the test line of each of the plurality of immunoassay test strips, compare the results of processing the image to a control for each test line of each of the plurality of immunoassay test strips, and provide a risk indicator, wherein the risk indicator alerts a user to seek medical attention immediately.
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公开(公告)号:US09919922B2
公开(公告)日:2018-03-20
申请号:US13063623
申请日:2009-10-01
CPC分类号: B82Y30/00 , B82Y15/00 , C12Q1/6825 , C12Q1/689 , Y02A50/57 , C12Q2565/601
摘要: The present invention is directed to a nucleic acid detection device and method that incorporates bio-nanosensor technology to detect duplex DNA. The device is particularly applicable in detecting the presence or absence of duplex DNA and its correlation to the diagnosis of infectious diseases. In one embodiment, the infectious disease is Lyme disease or a bacterial or viral infection. The device comprises a bio-nanosensor element comprising ssDNA primed nanotubes, either single walled or multi-walled. The method comprises contacting the bio-nanosensor element with a test solution potentially containing DNA of interest. DNA of interest that hybridizes to the ssDNA results in a measurable change in the electrical properties of the bio-nanosensor. Correlations between the results provided by the device and the presence of disease states can result in rapid diagnosis of diseases such as Lyme disease or foodborne infections such as salmonellosis.
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