公开(公告)号：US06312688B1

公开(公告)日：2001-11-06

申请号：US09155078

申请日：1999-03-02

申请人： Annemarie Poustka ,  Petra Kioschis ,  Jocelyn Laporte ,  Ling Jia Hu ,  Jean Louis Mandel ,  Niklas Dahl

发明人： Annemarie Poustka ,  Petra Kioschis ,  Jocelyn Laporte ,  Ling Jia Hu ,  Jean Louis Mandel ,  Niklas Dahl

IPC分类号： A61K3846

CPC分类号： C12N9/16 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00

摘要： The present invention relates to a tyrosine-phosphatase-related protein, a DNA which codes for such a protein and a process for producing such a protein. In addition, the invention concerns the use of the DNA and protein and antibodies directed against the protein.

摘要翻译： 本发明涉及酪氨酸磷酸酶相关蛋白，编码这种蛋白质的DNA及其生产方法。 此外，本发明涉及使用针对蛋白质的DNA和蛋白质和抗体。

公开(公告)号：US20100298280A1

公开(公告)日：2010-11-25

申请号：US12602200

申请日：2008-06-13

申请人： Petra Kioschis-Schneider ,  Mathias Hafner ,  Manuel Ammer-Schläger ,  Sandra Ritz ,  Andreas Holloschi ,  Erich E. Wanker

发明人： Petra Kioschis-Schneider ,  Mathias Hafner ,  Manuel Ammer-Schläger ,  Sandra Ritz ,  Andreas Holloschi ,  Erich E. Wanker

IPC分类号： A61K31/58 ,  A61K31/352 ,  C12N15/12 ,  C12N15/63 ,  C12N5/10 ,  C12Q1/68 ,  A61P25/28

CPC分类号： A61K31/00 ,  A61K31/352 ,  A61K31/58 ,  G01N33/6896 ,  G01N2500/10 ,  G01N2800/2835

摘要： The present invention relates to tetranortriterpenoid compounds and pharmaceutical compositions thereof, which are provided for use in the treatment, diagnosis and/or prevention of trinucleotide repeat disorders (like a polyglutamine diseases, e.g Huntingdon's disease), amyloid diseases, neurodegenerative disease, protein misfolding diseases or tumors. The tetranortriterpenoid compounds of the present invention are further provided for the reduction and/or inhibition of the aggregation of amyloidogenic proteins, preferably of polyglutamine proteins (such as huntingtin) as well as for increasing proteasome activity. The present invention furthermore relates to nucleic acids, comprising the nucleotide sequences of two huntingtin fragments, as well as to cells and kits, which are useful in methods for assessing the aggregation of huntingtin and in methods for identifying compounds, which modulate the aggregation of huntingtin.

摘要翻译： 本发明涉及四唑类萜类化合物及其药物组合物，其用于治疗，诊断和/或预防三核苷酸重复病症（如聚谷氨酸病，如亨廷顿氏病），淀粉样蛋白病，神经变性疾病，蛋白质错误折叠疾病 或肿瘤。 进一步提供本发明的四硝酸萜类化合物用于还原和/或抑制淀粉样蛋白生成蛋白，优选聚谷氨酸蛋白（例如亨廷顿蛋白）的聚集以及用于增加蛋白酶体活性。 本发明还涉及包含两个亨廷顿蛋白片段的核苷酸序列的核酸，以及可用于评价亨廷汀蛋白聚集的方法的细胞和试剂盒，以及用于鉴定调节亨廷顿蛋白聚集的化合物的方法 。