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    Protein having antithrombotic activity and method for producing the same
    2.
    发明授权
    Protein having antithrombotic activity and method for producing the same 失效
    具有抗血栓形成活性的蛋白质及其制造方法

    公开(公告)号：US06710031B2

    公开(公告)日：2004-03-23

    申请号：US09969763

    申请日：2001-10-04

    申请人： Naoyuki Fukuchi ,  Morikazu Kito ,  Takashi Kayahara ,  Fumie Futaki ,  Kohki Ishikawa ,  Eiichiro Suzuki ,  Keiko Gondoh ,  Nobuhisa Shimba ,  Naoyuki Yamada

    发明人： Naoyuki Fukuchi ,  Morikazu Kito ,  Takashi Kayahara ,  Fumie Futaki ,  Kohki Ishikawa ,  Eiichiro Suzuki ,  Keiko Gondoh ,  Nobuhisa Shimba ,  Naoyuki Yamada

    IPC分类号： A61K3846

    CPC分类号： C07K14/46 ,  C07K14/745

    摘要： A method for producing a protein having an antithrombotic activity, which comprises replacing, in a protein that has an amino acid sequence having a homology of not less than 30% to the amino acid sequence of SEQ ID NO: 1 and forms a higher order structure composed of a first &bgr; strand (&bgr;1), a first &agr; helix (&agr;1), a second &agr; helix (&agr;2), a second &bgr; strand (&bgr;2), a loop, a third &bgr; strand (&bgr;3), a fourth &bgr; strand (&bgr;4) and a fifth &bgr; strand (&bgr;5) in this order from the amino terminus, at least one amino acid residue in a region from &agr;2 to &bgr;2 and/or a region from &bgr;3 to &bgr;4 so that electric charge of the amino acid residue is changed towards positive direction.

    摘要翻译： 一种具有抗血栓形成活性的蛋白质的制造方法，其特征在于，具有与SEQ ID NO：1的氨基酸序列具有不小于30％的同源性的氨基酸序列的蛋白质，并形成高级结构 由第一β链（β1），第一α螺旋（alpha1），第二α螺旋（α2），第二β链（β2），环，第三β链（β3），第四条β链 β4）和第五个β链（β5），从氨基末端起始，α2至β2区域和/或β3至β4区域中的至少一个氨基酸残基，使得氨基酸残基的电荷为 转向正向。

    Gastric emptying-promoting composition
    3.
    发明授权
    Gastric emptying-promoting composition 失效
    胃排空促进组合物

    公开(公告)号：US06656464B2

    公开(公告)日：2003-12-02

    申请号：US09216857

    申请日：1998-12-21

    申请人： Takaharu Kondo

    发明人： Takaharu Kondo

    IPC分类号： A61K3846

    CPC分类号： A61K38/465 ,  A61K45/06 ,  A61K2300/00

    摘要： Compositions having an effect of promoting gastric emptying. These compositions comprise a lipase which was found to have an effect of promoting gastric emptying together with lipase activity-free ingredient(s) acting on the digestive tracts such as a prokinetic, a histamine H2 receptor antagonist, a proton pump inhibitor and/or a stomachic ingredient. They are efficaciously employed as medicaments for ameliorating or treating chronic gastrointestinal symptoms such as sinking feelings, heartburn and heaviness in the stomach, i.e., complaints about the digestive tracts.

    摘要翻译： 具有促进胃排空作用的组合物。 这些组合物包含脂肪酶，其被发现具有促进胃排空的作用以及作用于消化道例如促动力，组胺H2受体拮抗剂，质子泵抑制剂和/或 胃部成分 它们有效地用作改善或治疗慢性胃肠道症状的药物，例如下沉的感觉，胃灼热和胃中的沉重，即关于消化道的投诉。

    Phospholipase D polypeptide and DNA sequences
    6.
    发明授权
    Phospholipase D polypeptide and DNA sequences 失效
    磷脂酶D多肽和DNA序列

    公开(公告)号：US06379665B1

    公开(公告)日：2002-04-30

    申请号：US09536224

    申请日：2000-03-27

    申请人： Michael A. Frohman ,  Andrew J. Morris ,  Joanne Engebrecht

    发明人： Michael A. Frohman ,  Andrew J. Morris ,  Joanne Engebrecht

    IPC分类号： A61K3846

    CPC分类号： C12N9/1205 ,  C07K14/4722 ,  C12N9/16 ,  C12N9/20

    摘要： Provided are novel phospholipase D DNA and amino acid sequences. The sequences are useful in methods and compositions for identifying phospholipase D mediator molecules which are in turn useful in therapeutic pharmaceutical compositions for treating rheumatoid arthritis, psoriasis, ulcerative colitis, in wound healing and for treating other diseases or conditions characterized by exhibition of an inflammatory response or in the treatment of cancer and other diseases characterized by pathogenic mitogenicity.

    摘要翻译： 提供新的磷脂酶D DNA和氨基酸序列。 该序列可用于鉴定磷脂酶D介体分子的方法和组合物，其又可用于治疗类风湿性关节炎，牛皮癣，溃疡性结肠炎，伤口愈合的治疗性药物组合物和用于治疗特征为炎症反应特征的其它疾病或病症 或用于治疗特征为致病有丝分裂原的癌症和其他疾病。

    Recombinant kid pregastric esterase and methods for its production and use
    7.
    发明授权
    Recombinant kid pregastric esterase and methods for its production and use 有权
    重组儿童pregastric酯酶及其生产和使用的方法

    公开(公告)号：US06375947B1

    公开(公告)日：2002-04-23

    申请号：US09186489

    申请日：1998-11-05

    申请人： Paul L. Bolen ,  Paul L. Cihak ,  Lewis G. Scharpf, Jr.

    发明人： Paul L. Bolen ,  Paul L. Cihak ,  Lewis G. Scharpf, Jr.

    IPC分类号： A61K3846

    CPC分类号： C12N9/20 ,  A23C19/043 ,  A61K38/00

    摘要： The present invention provides kPGE and derivative polypeptides which are capable of being produced by genetic recombination and used to produce EMCs. This invention further provides nucleic acid sequences encoding kPGE and derivative polypeptides which can be used to create recombinant host cells that express kPGE and derivative polypeptides. A further subject of the present of invention is a fusion polypeptide called polyHis-enterokinase which increases expression of esterases and lipases when fused to the N-terminal of the esterase or lipase. This invention also provides a method for treating animals with an esterase or lipase deficiency by administering rkPGE to the animal in a therapeutically effective amount.

    摘要翻译： 本发明提供能够通过遗传重组产生并用于产生EMC的kPGE和衍生多肽。 本发明进一步提供编码kPGE和衍生多肽的核酸序列，其可用于产生表达kPGE和衍生多肽的重组宿主细胞。 本发明的另一个主题是称为聚合 - 肠蛋白酶的融合多肽，其在与酯酶或脂肪酶的N末端融合时增加酯酶和脂肪酶的表达。 本发明还提供了通过以治疗有效量向动物施用rkPGE来治疗具有酯酶或脂肪酶缺乏症的动物的方法。