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公开(公告)号：US09388167B2
公开(公告)日：2016-07-12
申请号：US14431319
申请日：2013-10-08
IPC分类号： C07D239/30 , C07D403/06
CPC分类号： C07D403/06 , C07D239/30
摘要： The present invention provides a process for preparing a compound of formula: (Formula XI and XII) (XI) (XII) wherein X, Y, Z, A, B and E are as defined herein, by reacting a compound of formula: (Formula XIII) (XIII) with a compound of formula: (Formula XIV and XV) (XIV) (XV) respectively, in the presence of a transition metal catalyst, a ligand suitable for use with 15 the catalyst and a reducing agent. The invention also provides novel intermediates.
摘要翻译： 本发明提供一种制备下式的化合物的方法：式（XIII）（Ⅺ）（Ⅻ）其中X，Y，Z，A，B和E如本文所定义， 式（ⅩⅢ）（ⅩⅢ）分别与式（ⅩⅣ和ⅩⅤ）（ⅩⅣ）（ⅩⅤ）化合物在过渡金属催化剂，适合与催化剂和还原剂一起使用的配位体存在下进行。 本发明还提供新颖的中间体。
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公开(公告)号：US20230090609A1
公开(公告)日：2023-03-23
申请号：US17757740
申请日：2020-12-16
IPC分类号： C07D263/57 , C07D493/18
摘要： The present invention is directed to an efficient process for preparing benzoxazole derivatives comprising the step of reacting a 4-Amino-3-hydroxybenzoic acid compound of Formula III with a 3,5-Dichlorophenyl ortho ester compound of Formula I to provide the compound of Formula I wherein R1, R2a, R2b and R2c are as described herein.
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公开(公告)号：US20160024540A1
公开(公告)日：2016-01-28
申请号：US14775979
申请日：2014-03-25
发明人： Sebastien Debarge , David Thomas Erdman , Michael John Karmilowicz , Rajesh Kumar , Padraig Mary O'Neill
IPC分类号： C12P13/00 , C12N9/10 , C07C59/74 , C07D307/60 , C07C227/12 , C12P17/04 , C07D307/66
CPC分类号： C12P13/001 , C07B53/00 , C07C59/74 , C07C227/12 , C07C227/18 , C07D307/60 , C07D307/66 , C12N9/1096 , C12P13/005 , C12P17/04 , C07C229/08
摘要： The invention provides processes for the manufacture of a compound of formula (IA). The invention further provides improved methods for the conversion of the compound of formula (IA) into pregabalin.
摘要翻译： 本发明提供了制备式（IA）化合物的方法。 本发明进一步提供了将式（IA）化合物转化为普瑞巴林的改进方法。
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公开(公告)号：US09499520B2
公开(公告)日：2016-11-22
申请号：US15133621
申请日：2016-04-20
IPC分类号： C07D403/06 , C07D239/30
CPC分类号： C07D403/06 , C07D239/30
摘要： The present invention provides a process for preparing a compound of formula: (Formula XI and XII) (XI) (XII) wherein X, Y, Z, A, B and E are as defined herein, by reacting a compound of formula: (Formula XIII) (XIII) with a compound of formula: (Formula XIV and XV) (XIV) (XV) respectively, in the presence of a transition metal catalyst, a ligand suitable for use with 15 the catalyst and a reducing agent. The invention also provides novel intermediates.
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公开(公告)号：US20240066028A1
公开(公告)日：2024-02-29
申请号：US18255949
申请日：2021-12-16
IPC分类号： A61K31/496 , A61K9/00 , A61K9/48 , A61K9/20
CPC分类号： A61K31/496 , A61K9/006 , A61K9/4858 , A61K9/2013
摘要： Provided is a pharmaceutical formulation in the form of a softgel dosage form including a calcitonin gene-related peptide (CGRP) inhibitor, a lipophilic phase, and at least one lipophilic surfactant. Also provided is a method for increasing bioavailability of a calcitonin gene-related peptide (CGRP) inhibitor in a subject, including orally administering the pharmaceutical formulation to increase the bioavailability of the CGRP inhibitor in the subject.
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公开(公告)号：US20160229842A1
公开(公告)日：2016-08-11
申请号：US15133621
申请日：2016-04-20
IPC分类号： C07D403/06 , C07D239/30
CPC分类号： C07D403/06 , C07D239/30
摘要： The present invention provides a process for preparing a compound of formula: (Formula XI and XII) (XI) (XII) wherein X, Y, Z, A, B and E are as defined herein, by reacting a compound of formula: (Formula XIII) (XIII) with a compound of formula: (Formula XIV and XV) (XIV) (XV) respectively, in the presence of a transition metal catalyst, a ligand suitable for use with 15 the catalyst and a reducing agent. The invention also provides novel intermediates.
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公开(公告)号：US20150239867A1
公开(公告)日：2015-08-27
申请号：US14431319
申请日：2013-10-08
IPC分类号： C07D403/06 , C07D239/30
CPC分类号： C07D403/06 , C07D239/30
摘要： The present invention provides a process for preparing a compound of formula: (Formula XI and XII) (XI) (XII) wherein X, Y, Z, A, B and E are as defined herein, by reacting a compound of formula: (Formula XIII) (XIII) with a compound of formula: (Formula XIV and XV) (XIV) (XV) respectively, in the presence of a transition metal catalyst, a ligand suitable for use with 15 the catalyst and a reducing agent. The invention also provides novel intermediates.
摘要翻译： 本发明提供一种制备下式的化合物的方法：式（XIII）（Ⅺ）（Ⅻ）其中X，Y，Z，A，B和E如本文所定义， 式（ⅩⅢ）（ⅩⅢ）分别与式（ⅩⅣ和ⅩⅤ）（ⅩⅣ）（ⅩⅤ）化合物在过渡金属催化剂，适合与催化剂和还原剂一起使用的配位体存在下进行。 本发明还提供新颖的中间体。
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