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公开(公告)号：US20060264453A1
公开(公告)日：2006-11-23
申请号：US11352092
申请日：2006-02-09
IPC分类号： A61K31/4745 , A61K31/045
CPC分类号： A61K9/0046 , A61K9/0019 , A61K9/0048 , A61K31/045 , A61K31/436 , A61K31/44 , A61K31/4745 , A61K47/10 , A61K47/12 , A61K47/44
摘要： Described herein are liquid rapamycin formulations. Described herein are methods of treating or preventing diseases or conditions, such as choroidal neovascularization, wet AMD and dry AMD, and preventing transition of dry AMD to wet AMD, using the liquid rapamycin formulations described herein.
摘要翻译： 本文描述的是液体雷帕霉素制剂。 本文描述了使用本文所述的液体雷帕霉素制剂治疗或预防疾病或病症如脉络膜新生血管形成，湿性AMD和干性AMD的方法，以及防止干性AMD转变为湿性AMD。
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公开(公告)号：US20060258698A1
公开(公告)日：2006-11-16
申请号：US11351761
申请日：2006-02-09
IPC分类号： A61K31/4745
CPC分类号： A61K9/0046 , A61K9/0019 , A61K9/0048 , A61K31/045 , A61K31/436 , A61K31/44 , A61K31/4745 , A61K47/10 , A61K47/12 , A61K47/44
摘要： Diseases and conditions associated with tissues of the body, including but not limited to tissues in the eye, can be effectively treated, prevented, inhibited, onset delayed, or regression caused by administering therapeutic agents to those tissues. Described herein are liquid formulations which deliver a variety of therapeutic agents, including but not limited to rapamycin, to a subject for an extended period of time; liquid formulations which form a non-dispersed mass when placed in an aqueous medium of a subject; non-dispersed mass-forming liquid formulations which form a gel or gel-like substance in an aqueous medium; liquid formulations, comprising a therapeutic agent and a plurality of polymers; and methods for delivering therapeutic agents to a subject for an extended period of time using the liquid formulations. The liquid formulation may be placed in an aqueous medium of a subject, including but not limited to via intraocular or periocular administration, or placement proximate to a site of a disease or condition to be treated in a subject. A method may be used to administer rapamycin to treat or prevent angiogenesis, choroidal neovascularization, or age-related macular degeneration, or wet age-related macular degeneration in a subject. The liquid formulations may comprise rapamycin or other therapeutic agents.
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公开(公告)号：US20050064010A1
公开(公告)日：2005-03-24
申请号：US10945682
申请日：2004-09-20
IPC分类号： A61K9/00 , A61K31/436 , A61K31/4745
CPC分类号： A61K9/0048 , A61K9/0019 , A61K31/436
摘要： Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration.
摘要翻译： 通过将这些组织交叉施用治疗剂，可以有效地治疗与眼后段组织相关的疾病。 用于递送治疗剂使得它们穿过巩膜并到达这些组织的组合物，装置和方法包括在巩膜附近或在巩膜附近注射溶液或悬浮液，并植入包含与巩膜内或巩膜内的治疗剂的固体结构。 这些方法可用于施用雷帕霉素或相关化合物以治疗与年龄相关的黄斑变性相关的脉络膜新生血管形成。
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公开(公告)号：US20060182771A1
公开(公告)日：2006-08-17
申请号：US11351844
申请日：2006-02-09
IPC分类号： A61K31/4745 , A61K9/00
CPC分类号： A61K9/0046 , A61K9/0019 , A61K9/0048 , A61K31/045 , A61K31/436 , A61K31/44 , A61K31/4745 , A61K47/10 , A61K47/12 , A61K47/44
摘要： Diseases and conditions associated with tissues of the body, including tissues in the eye, can be effectively treated by administering therapeutic agents to those tissues. Described herein are self-emulsifying formulations and methods for delivering therapeutic agents to such tissues. A self-emulsifying formulation may be delivered to an aqueous medium of a subject, including but not limited to the vitreous. A method may, for instance, be used to administer rapamycin or related compounds to treat or prevent choroidal neovascularization associated with age-related macular degeneration, or to treat dry AMD. A self-emulsifying formulation may also be administered systemically, such as orally, to treat transplant rejection in a subject. A self-emulsifying formulation may comprise rapamycin, related compounds, or other therapeutic agents.
摘要翻译： 可以通过向这些组织施用治疗剂来有效地治疗与身体组织（包括眼睛中的组织）相关的疾病和病症。 本文描述了将治疗剂递送到这种组织的自乳化制剂和方法。 自乳化制剂可以递送到受试者的水性介质，包括但不限于玻璃体。 例如，可以使用方法来施用雷帕霉素或相关化合物以治疗或预防与年龄相关性黄斑变性相关的脉络膜新血管形成，或治疗干性AMD。 自乳化制剂也可以全身施用，例如口服给药以治疗受试者的移植排斥。 自乳化制剂可以包含雷帕霉素，相关化合物或其它治疗剂。
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