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1.发明申请Echogen microparticles essentially used as a contrast agent for ultrasound exploration and/or as emboli for ultrasound detection 审中-公开回波微粒基本上用作超声波探查的造影剂和/或用于超声检测的栓塞公开(公告)号：US20060153776A1
公开(公告)日：2006-07-13
申请号：US10543660
申请日：2004-01-28
申请人： Celine Chaix , Nathalie Lassau , Angelo Paci , Pierre Peronneau , Philippe Reb , Alain Roche , Valerie Rouffiac
发明人： Celine Chaix , Nathalie Lassau , Angelo Paci , Pierre Peronneau , Philippe Reb , Alain Roche , Valerie Rouffiac
IPC分类号： A61K49/22
CPC分类号： A61K49/225
摘要： A composition for ultrasonic exploration including echogenic microparticles including a macromolecular network of reticulated hydrophilic polymers and/or copolymers which micro-particles have a diameter between 0.1 μm and 10 μm and are obtained from an inverse mini-emulsion of identical or different monomers or polymers.
摘要翻译： 一种用于超声波探伤的组合物，包括回波微粒，其包括网状亲水聚合物和/或共聚物的大分子网络，微粒具有0.1μm和10μm之间的直径，并且由相同或不同单体或聚合物的反相微乳液获得。
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2.发明申请公开(公告)号：US20120189552A1
公开(公告)日：2012-07-26
申请号：US13435520
申请日：2012-03-30
申请人： Philippe Reb
发明人： Philippe Reb
CPC分类号： A61K49/1818 , A61K9/5026 , A61K31/704 , A61K33/24 , A61K45/06 , A61K49/0438 , A61K49/048 , A61K49/0485 , A61K49/10 , B82Y5/00
摘要： The present invention relates to compositions and methods for treating diseases and disorders including cancer and various other angiogenic-dependent diseases, vascular malfunctions, arteriovenous malformations (AVM), hemorrhagic processes and treatment of pain, in particular tumor-related pain by drug delivery and/or therapeutic embolization using microspheres. More particularly the invention relates to microspheres containing non-ionic contrast agents, to compositions comprising these microspheres, as well as methods for preparing and using such compositions for embolization therapy. The invention further relates to compositions and methods using detectable microspheres for targeted drug delivery, irrespective of whether embolization is also needed.
摘要翻译： 本发明涉及用于治疗疾病和病症的组合物和方法，包括癌症和各种其他血管生成依赖性疾病，血管功能障碍，动静脉畸形（AVM），出血过程和疼痛的治疗，特别是通过药物递送的肿瘤相关疼痛和/ 或使用微球治疗栓塞。 更具体地，本发明涉及含有非离子造影剂的微球，包含这些微球的组合物，以及用于制备和使用这种组合物用于栓塞治疗的方法。 本发明还涉及使用可检测的微球体用于靶向药物递送的组合物和方法，而不管是否还需要栓塞。
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3.发明授权公开(公告)号：US08226926B2
公开(公告)日：2012-07-24
申请号：US11430789
申请日：2006-05-09
申请人： Philippe Reb
发明人： Philippe Reb
CPC分类号： A61K49/1818 , A61K9/5026 , A61K31/704 , A61K33/24 , A61K45/06 , A61K49/0438 , A61K49/048 , A61K49/0485 , A61K49/10 , B82Y5/00
摘要： The present invention relates to compositions and methods for treating diseases and disorders including cancer and various other angiogenic-dependent diseases, vascular malfunctions, arteriovenous malformations (AVM), hemorrhagic processes and treatment of pain, in particular tumor-related pain by drug delivery and/or therapeutic embolization using microspheres. More particularly the invention relates to microspheres containing non-ionic contrast agents, to compositions comprising these microspheres, as well as methods for preparing and using such compositions for embolization therapy. The invention further relates to compositions and methods using detectable microspheres for targeted drug delivery, irrespective of whether embolization is also needed.
摘要翻译： 本发明涉及用于治疗疾病和病症的组合物和方法，包括癌症和各种其他血管生成依赖性疾病，血管功能障碍，动静脉畸形（AVM），出血过程和疼痛的治疗，特别是通过药物递送的肿瘤相关疼痛和/ 或使用微球治疗栓塞。 更具体地，本发明涉及含有非离子造影剂的微球，包含这些微球的组合物，以及用于制备和使用这种组合物用于栓塞治疗的方法。 本发明还涉及使用可检测的微球体用于靶向药物递送的组合物和方法，而不管是否还需要栓塞。
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公开(公告)号：US20110182998A1
公开(公告)日：2011-07-28
申请号：US13014172
申请日：2011-01-26
申请人： Philippe Reb , Pierre Marion , Barbara De Gioannis , James Krom
发明人： Philippe Reb , Pierre Marion , Barbara De Gioannis , James Krom
CPC分类号： A61L24/043 , A61B6/504 , A61K9/16 , A61K9/1682 , A61K38/39 , A61L24/06 , A61L2430/36 , C08F2/44 , C08F220/54 , C08J3/246 , C08J2333/26 , C08J2389/00 , C08J2489/06 , C08L33/26 , C08F222/385
摘要： Provided herein, for example, are microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Also provided are methods of producing microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Further provided herein, for example, are compositions comprising the microspheres and methods of using the microspheres and compositions thereof.
摘要翻译： 例如，本文提供了包含明胶或明胶替代物的微球，以及N-三羟甲基甲基丙烯酰胺单体单元，二乙基氨基乙基丙烯酰胺单体单元和N，N-亚甲基双丙烯酰胺单体单元的共聚物。 还提供了制备包含明胶或明胶替代物和N-三羟甲基甲基丙烯酰胺单体单元，二乙基氨基乙基丙烯酰胺单体单元和N，N-亚甲基双丙烯酰胺单体单元的共聚物的微球的方法。 本文进一步提供的是包含微球体的组合物以及使用微球体及其组合物的方法。
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5.发明授权公开(公告)号：US08709384B2
公开(公告)日：2014-04-29
申请号：US13435520
申请日：2012-03-30
申请人： Philippe Reb
发明人： Philippe Reb
CPC分类号： A61K49/1818 , A61K9/5026 , A61K31/704 , A61K33/24 , A61K45/06 , A61K49/0438 , A61K49/048 , A61K49/0485 , A61K49/10 , B82Y5/00
摘要： The present invention relates to compositions and methods for treating diseases and disorders including cancer and various other angiogenic-dependent diseases, vascular malfunctions, arteriovenous malformations (AVM), hemorrhagic processes and treatment of pain, in particular tumor-related pain by drug delivery and/or therapeutic embolization using microspheres. More particularly the invention relates to microspheres containing non-ionic contrast agents, to compositions comprising these microspheres, as well as methods for preparing and using such compositions for embolization therapy. The invention further relates to compositions and methods using detectable microspheres for targeted drug delivery, irrespective of whether embolization is also needed.
摘要翻译： 本发明涉及用于治疗疾病和病症的组合物和方法，包括癌症和各种其他血管生成依赖性疾病，血管功能障碍，动静脉畸形（AVM），出血过程和疼痛的治疗，特别是通过药物递送的肿瘤相关疼痛和/ 或使用微球治疗栓塞。 更具体地，本发明涉及含有非离子造影剂的微球，包含这些微球的组合物，以及用于制备和使用这种组合物用于栓塞治疗的方法。 本发明还涉及使用可检测的微球体用于靶向药物递送的组合物和方法，而不管是否还需要栓塞。
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公开(公告)号：US20060251582A1
公开(公告)日：2006-11-09
申请号：US11430789
申请日：2006-05-09
申请人： Philippe Reb
发明人： Philippe Reb
CPC分类号： A61K49/1818 , A61K9/5026 , A61K31/704 , A61K33/24 , A61K45/06 , A61K49/0438 , A61K49/048 , A61K49/0485 , A61K49/10 , B82Y5/00
摘要： The present invention relates to compositions and methods for treating diseases and disorders including cancer and various other angiogenic-dependent diseases, vascular malfunctions, arteriovenous malformations (AVM), hemorrhagic processes and treatment of pain, in particular tumor-related pain by drug delivery and/or therapeutic embolization using microspheres. More particularly the invention relates to microspheres containing non-ionic contrast agents, to compositions comprising these microspheres, as well as methods for preparing and using such compositions for embolization therapy. The invention further relates to compositions and methods using detectable microspheres for targeted drug delivery, irrespective of whether embolization is also needed.
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