Biocompatible hydrogel, process for producing same, and use thereof in a mechanical viscosupplementation system

    公开(公告)号:US12102735B2

    公开(公告)日:2024-10-01

    申请号:US17298349

    申请日:2019-12-02

    申请人: NVD

    摘要: A biocompatible hydrogel has between 0.3% and 30% by weight of dry matter of a copolymer formed at least from acrylamide, chitosan and N,N′-methylenebisacrylamide, as well as a diffusing agent. The diffusing agent is advantageously selected from the group consisting of inert ingredients which have biomechanical properties and active ingredients. A method of manufacturing the hydrogel by copolymerizing, washing, and adding the diffusing agent is provided, as well as a mechanical visco-supplementation system adapted for external or internal use that includes the hydrogel, and an external or internal mechanical visco-supplementation kit including an acrylamide and chitosan copolymer crosslinked with N,N′-methylenebisacrylamide, and a diffusing agent in solid phase or in suspension, the copolymer and the diffusing agent having been previously mixed in the form of a hydrogel during manufacture or being adapted to be mixed extemporaneously to form a hydrogel.

    CONTACT LENS AND MANUFACTURING METHOD THEREOF

    公开(公告)号:US20240168200A1

    公开(公告)日:2024-05-23

    申请号:US17772147

    申请日:2021-11-12

    摘要: A contact lens and a manufacturing method thereof are provided. The contact lens includes a lens and a hydrophilic polymer layer. The hydrophilic polymer layer and the lens are entangled with each other. The hydrophilic polymer layer and the lens form an interpenetrating polymer network or a semi-interpenetrating polymer network. The hydrophilic polymer layer is formed by polymerizing an initiator adsorbed on the lens with at least one hydrophilic vinyl monomer. The contact lens has excellent hydrophilicity. Since the manufacturing process of the contact lens is simple, the manufacturing efficiency can be improved, and the manufacturing cost can be reduced. Moreover, the manufacturing method can be applied to lenses made of various materials and used for their surface modification, so it is widely applicable.