公开(公告)号：US20070185432A1

公开(公告)日：2007-08-09

申请号：US11538249

申请日：2006-10-03

申请人： Robert Etheredge ,  Dennis Goldberg ,  Phillip Friden ,  John Petersen

发明人： Robert Etheredge ,  Dennis Goldberg ,  Phillip Friden ,  John Petersen

IPC分类号： A61N1/30

CPC分类号： A61B17/205 ,  A61M37/0015 ,  A61M2037/0061

摘要： The electrokinetic methotrexate delivery system includes at least one applicator having a multiplicity of non-conductive micro-needles carried on a non-conductive surface of the applicator. The opposite surface is formed of electrically conductive material for contact with an active electrode. The applicator includes a matrix containing a medicament, e.g., methotrexate, or a carrier therefor between the opposite surfaces. When the applicator is applied to the individual's skin with the micro-needles penetrating the skin, an electrical current is completed through the power source, the active electrode, methotrexate, or electrically conductive carrier therefor, the targeted treatment site, the individual's body, a ground electrode and the power supply, thereby electokinetically driving the medicament through the non-conductive micro-needles into the targeted treatment site.

摘要翻译： 电动氨甲蝶呤递送系统包括至少一个施用器，其具有承载在施用器的非导电表面上的多个非导电微针。 相对表面由用于与有源电极接触的导电材料形成。 施用器包括在相对表面之间包含药物，例如甲氨蝶呤或其载体的基质。 当施用器被微针穿透皮肤施加到个体的皮肤上时，通过电源，有效电极，甲氨蝶呤或导电载体，目标治疗部位，个体的身体， 接地电极和电源，从而通过非导电微针将药物电动驱动到目标治疗部位。

公开(公告)号：US20070066934A1

公开(公告)日：2007-03-22

申请号：US11228461

申请日：2005-09-19

申请人： Robert Etheredge ,  Dennis Goldberg ,  Phillip Friden ,  John Peterson

发明人： Robert Etheredge ,  Dennis Goldberg ,  Phillip Friden ,  John Peterson

IPC分类号： A61B17/20

CPC分类号： A61B17/205 ,  A61M37/0015

摘要： The electrokinetic medicament delivery system includes at least one applicator having a multiplicity of non-conductive micro-needles carried on a non-conductive surface of the applicator. The opposite surface is formed of electrically conductive material for contact with an active electrode. The applicator includes a matrix containing a medicament or a carrier therefor between the opposite surfaces. When the applicator is applied to the individual's skin with the micro-needles penetrating the skin, an electrical current is completed through the power source, the active electrode, medicament, or electrically conductive carrier therefor, the targeted treatment site, the individual's body, a ground electrode and the power supply, thereby electokinetically driving the medicament through the non-conductive micro-needles into the targeted treatment site.

摘要翻译： 电动药物递送系统包括至少一个施用器，其具有承载在施用器的非导电表面上的多个非导电微针。 相对表面由用于与有源电极接触的导电材料形成。 施用器包括在相对表面之间包含药物或载体的基质。 当施用器被微针穿透皮肤施加到个体的皮肤上时，通过动力源，有效电极，药物或导电载体，目标治疗部位，个体的身体， 接地电极和电源，从而通过非导电微针将药物电动驱动到目标治疗部位。

公开(公告)号：US5154924A

公开(公告)日：1992-10-13

申请号：US404089

申请日：1989-09-07

申请人： Phillip Friden

发明人： Phillip Friden

IPC分类号： A61K39/395 ,  A61K38/00 ,  A61K47/48 ,  A61K51/10 ,  C07K14/475 ,  C07K14/48 ,  C07K14/79 ,  C12N9/08

CPC分类号： C12N9/0065 ,  A61K47/48415 ,  A61K51/1093 ,  C07K14/475 ,  C07K14/48 ,  C07K14/79 ,  C12Y111/01007 ,  A61K2123/00 ,  A61K38/00 ,  C07K2319/00

摘要： The present invention pertains to a method for delivering a neuropharmaceutical agent across the blood brain barrier to the brain of a host. The method comprises administering to the host a therapeutically effective amount of an antibody-neuropharmaceutical agent conjugate wherein the antibody is reactive with a transferrin receptor. Other aspects of this invention include a delivery system comprising an antibody reactive with a transferrin receptor linked to a neuropharmaceutical agent and method for treating hosts afflicted with a disease associated with a neurological disorder.

摘要翻译： 本发明涉及一种将神经药物穿过血脑屏障传递至宿主脑的方法。 该方法包括向宿主施用治疗有效量的抗体 - 神经药物偶联物，其中抗体与转铁蛋白受体反应。 本发明的其它方面包括递送系统，其包括与与神经药物连接的转铁蛋白受体反应的抗体和用于治疗患有与神经障碍相关的疾病的宿主的方法。