公开(公告)号：US08101352B2

公开(公告)日：2012-01-24

申请号：US12305258

申请日：2007-06-26

申请人： Guido Sauter ,  Ronald Simon ,  Phillip Stahl ,  Frederik Holst ,  Khawla Al-Kuraya ,  Christian Ruiz

发明人： Guido Sauter ,  Ronald Simon ,  Phillip Stahl ,  Frederik Holst ,  Khawla Al-Kuraya ,  Christian Ruiz

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106

摘要： The present invention relates to an in-vitro method of identifying a tumor resulting from a proliferative breast disease as responsive to anti-estrogen treatment. Further, the invention relates to an in-vitro method of identifying a candidate patient with a proliferative breast disease as suitable for anti-estrogen treatment. In a further aspect, the invention provides an in-vitro method of identifying an individual with a non-cancerous proliferative breast disease who is at risk of developing breast cancer. The invention also provides kits for performing the above methods.

摘要翻译： 本发明涉及鉴定由抗雌激素治疗反应的增殖性乳腺疾病引起的肿瘤的体外方法。 此外，本发明涉及鉴定具有适合于抗雌激素治疗的增殖性乳腺疾病的候选患者的体外方法。 在另一方面，本发明提供了一种鉴定患有具有发展为乳腺癌风险的非癌性增殖性乳腺疾病的个体的体外方法。 本发明还提供了用于执行上述方法的试剂盒。