公开(公告)号：US06369073B1

公开(公告)日：2002-04-09

申请号：US09677328

申请日：2000-10-02

申请人： Fabio Giannessi ,  Mauro Marzi ,  Patrizia Minetti ,  Francesco De Angelis ,  Maria Ornella Tinti ,  Piero Chiodi ,  Arduino Arduini

发明人： Fabio Giannessi ,  Mauro Marzi ,  Patrizia Minetti ,  Francesco De Angelis ,  Maria Ornella Tinti ,  Piero Chiodi ,  Arduino Arduini

IPC分类号： A61K3146

CPC分类号： C07D257/04 ,  C07C229/22 ,  C07C229/26 ,  C07C271/12 ,  C07C271/22 ,  C07C275/16 ,  C07C311/06 ,  C07C335/08 ,  C07D295/15 ,  C07D453/02 ,  C07F9/5407

摘要： Compounds of formula (I) wherein the groups are as defined in the description are disclosed. The compounds of formula (I) are endowed with reversible inhibiting activity of carnitine palmitoyl-transferase and are useful in the preparation of medicaments useful in the pathologies related to a hyperactivity of carnitine palmitoyl-transferase, such as hyperglycemia, diabetes and pathologies related thereto, heart failure, ischemia.

公开(公告)号：USRE40861E1

公开(公告)日：2009-07-21

申请号：US11606322

申请日：2006-11-30

申请人： Fabio Giannessi ,  Mauro Marzi ,  Patrizia Minetti ,  Francesco De Angelis ,  Maria O. Tinti ,  Piero Chiodi ,  Arduino Arduini

发明人： Fabio Giannessi ,  Mauro Marzi ,  Patrizia Minetti ,  Francesco De Angelis ,  Maria O. Tinti ,  Piero Chiodi ,  Arduino Arduini

IPC分类号： A61K31/46 ,  C07D453/02

CPC分类号： C07D257/04 ,  C07C229/22 ,  C07C229/26 ,  C07C271/12 ,  C07C271/22 ,  C07C275/16 ,  C07C311/06 ,  C07C335/08 ,  C07D295/15 ,  C07D453/02 ,  C07F9/5407

摘要： Compounds of formula (I) wherein the groups are as defined in the description are disclosed. The compounds of formula (I) are endowed with reversible inhibiting activity of carnitine palmitoyl-transferase and are useful in the preparation of medicaments useful in the pathologies related to a hyperactivity of carnitine palmitoyl-transferase, such as hyperglycemia, diabetes and pathologies related thereto, heart failure, ischemia.

公开(公告)号：USRE41226E1

公开(公告)日：2010-04-13

申请号：US11607078

申请日：2006-12-01

申请人： Fabio Giannessi ,  Mauro Marzi ,  Patrizia Minetti ,  Francesco De Angelis ,  Maria Ornella Tinti ,  Piero Chiodi ,  Arduino Arduini

发明人： Fabio Giannessi ,  Mauro Marzi ,  Patrizia Minetti ,  Francesco De Angelis ,  Maria Ornella Tinti ,  Piero Chiodi ,  Arduino Arduini

IPC分类号： A61K31/27 ,  C07C271/06

CPC分类号： C07D257/04 ,  C07C229/22 ,  C07C229/26 ,  C07C271/12 ,  C07C271/22 ,  C07C275/16 ,  C07C311/06 ,  C07C335/08 ,  C07D295/15 ,  C07D453/02 ,  C07F9/5407

摘要： Compounds of formula (I) wherein the groups are as defined in the description are disclosed. The compounds of formula (I) are endowed with reversible inhibiting activity of carnitine palmitoyl-transferase and are useful in the preparation of medicaments useful in the pathologies related to a hyperactivity of carnitine polymitoyl-transferase, such as hyperglycemia, diabetes and pathologies related thereto, heart failure, ischemia.

摘要翻译： 公开了其中基团如说明书中定义的式（I）化合物。 式（I）化合物具有肉毒碱棕榈酰转移酶的可逆抑制活性，可用于制备与肉碱多聚酰胺转移酶多动症有关的病症，如高血糖症，糖尿病及其相关疾病， 心力衰竭，局部缺血。

公开(公告)号：US06444701B1

公开(公告)日：2002-09-03

申请号：US09986327

申请日：2001-11-08

申请人： Fabio Giannessi ,  Mauro Marzi ,  Patrizia Minetti ,  Francesco De Angelis ,  Maria Ornella Tinti ,  Piero Chiodi ,  Arduino Arduini

发明人： Fabio Giannessi ,  Mauro Marzi ,  Patrizia Minetti ,  Francesco De Angelis ,  Maria Ornella Tinti ,  Piero Chiodi ,  Arduino Arduini

IPC分类号： A61K31195

CPC分类号： C07D257/04 ,  C07C229/22 ,  C07C229/26 ,  C07C271/12 ,  C07C271/22 ,  C07C275/16 ,  C07C311/06 ,  C07C335/08 ,  C07D295/15 ,  C07D453/02 ,  C07F9/5407

摘要： Compounds of formula (I) wherein the groups are as defined in the description are disclosed. The compounds of formula (I) are endowed with reversible inhibiting activity of carnitine palmitoyl-transferase and are useful in the preparation of medicaments useful in the pathologies related to a hyperactivity of carnitine palmitoyl-transferase, such as hyperglycemia, diabetes and pathologies related thereto, heart failure, ischemia.

摘要翻译： 公开了式（I）化合物，其中基团如说明书中所定义。式（I）化合物具有肉碱棕榈酰转移酶的可逆抑制活性，并且可用于制备可用于与 肉碱棕榈酰转移酶的多动症，例如高血糖症，糖尿病和与之相关的病理，心力衰竭，局部缺血。