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5 条记录 (耗时 0.016 秒)

    Role of proteoglycans in drug dependence
    2.
    发明授权
    Role of proteoglycans in drug dependence 有权
    蛋白多糖在药物依赖中的作用

    公开(公告)号：US08119854B2

    公开(公告)日：2012-02-21

    申请号：US12085381

    申请日：2006-11-21

    申请人： Pietro Paolo Sanna

    发明人： Pietro Paolo Sanna

    IPC分类号： A01K67/00

    CPC分类号： C07K14/705 ,  A61K31/00

    摘要： The invention provides methods of preventing or treating drug addiction, or ameliorating the craving for an addictive drug, as well as compounds, peptides, and pharmaceutical compositions that may be used to prevent or treat drug addiction or ameliorate the craving for an addictive drug. The invention also provides methods for identifying agents that may be used to prevent or treat drug addiction, or ameliorate the craving for an addictive drug.

    摘要翻译： 本发明提供了预防或治疗药物成瘾或改善上瘾药物渴求的方法，以及可用于预防或治疗药物成瘾或改善成瘾药物渴求的化合物，肽和药物组合物的方法。 本发明还提供了用于鉴定可用于预防或治疗药物成瘾或改善对上瘾药物的欲望的药剂的方法。

    Methods and compositions for treating alcohol use disorders
    4.
    发明授权
    Methods and compositions for treating alcohol use disorders 有权

    公开(公告)号：US10039772B2

    公开(公告)日：2018-08-07

    申请号：US15350052

    申请日：2016-11-12

    申请人： Pietro Paolo Sanna

    发明人： Pietro Paolo Sanna

    IPC分类号： A61K31/585 ,  A61K31/56 ,  A61K31/4965 ,  A61K31/58

    摘要： Disclosed are methods and compositions for treating alcohol dependence by administration to a patient of an inhibitor of 11β-hydroxysteroid dehydrogenases (11β-HSD) to modulate glucocorticoid effects. One such compound is the 11β-HSD inhibitor carbenoxolone (18β-glycyrrhetinic acid 3β-O-hemisuccinate), which has been extensively employed in the clinic for the treatment of gastritis and peptic ulcer. Carbenoxolone is active on both 11β-HSD1 and 2 isoforms. Here, carbenoxolone is surprisingly shown to reduce both baseline and excessive drinking in rats and mice. The carbenoxolone diastereomer 18α-glycyrrhetinic acid 3β-O-hemisuccinate (αCBX), which the applicants discovered to be selective for 11β-HSD2, was also effective in reducing alcohol drinking in mice. Thus, 11β-HSD inhibitors are a new class of candidate alcohol abuse medications and existing 11β-HSD inhibitor drugs may be re-purposed for alcohol abuse treatment.

    METHODS AND COMPOSITIONS FOR TREATING ALCOHOL USE DISORDERS
    5.
    发明申请
    METHODS AND COMPOSITIONS FOR TREATING ALCOHOL USE DISORDERS 审中-公开

    公开(公告)号：US20170232007A1

    公开(公告)日：2017-08-17

    申请号：US15350052

    申请日：2016-11-12

    申请人： Pietro Paolo SANNA

    发明人： Pietro Paolo SANNA

    IPC分类号： A61K31/585 ,  A61K31/4965 ,  A61K31/58 ,  A61K31/56

    CPC分类号： A61K31/585 ,  A61K31/22 ,  A61K31/4965 ,  A61K31/56 ,  A61K31/573 ,  A61K31/58 ,  A61K38/39 ,  A61K45/06 ,  C07J63/008 ,  A61K2300/00

    摘要： Disclosed are methods and compositions for treating alcohol dependence by administration to a patient of an inhibitor of 11β-hydroxysteroid dehydrogenases (11β-HSD) to modulate glucocorticoid effects. One such compound is the 11β-HSD inhibitor carbenoxolone (18β-glycyrrhetinic acid 3β-O-hemisuccinate), which has been extensively employed in the clinic for the treatment of gastritis and peptic ulcer. Carbenoxolone is active on both 11β-HSD1 and 2 isoforms. Here, carbenoxolone is surprisingly shown to reduce both baseline and excessive drinking in rats and mice. The carbenoxolone diastereomer 18α-glycyrrhetinic acid 3β-O-hemisuccinate (αCBX), which the applicants discovered to be selective for 11β-HSD2, was also effective in reducing alcohol drinking in mice. Thus, 11β-HSD inhibitors are a new class of candidate alcohol abuse medications and existing 11β-HSD inhibitor drugs may be re-purposed for alcohol abuse treatment.