-
![3,5-DISUBSTUTUTED 1H-PYRROLO [2,3-B] PYRIDINES AS JNK INHIBITORS](/abs-image/US/2011/07/07/US20110166173A1/abs.jpg.150x150.jpg)
1.发明申请3,5-DISUBSTUTUTED 1H-PYRROLO [2,3-B] PYRIDINES AS JNK INHIBITORS 审中-公开3,5-DISUBSTUTUTED 1H-吡咯[2,3-B]吡啶作为JNK抑制剂公开(公告)号：US20110166173A1
公开(公告)日：2011-07-07
申请号：US10591551
申请日：2005-03-03
IPC分类号： A61K31/437 , C07D471/04 , A61P29/00 , A61P19/00 , A61P31/00 , A61P9/00 , A61P25/28 , A61P25/16 , A61P7/06 , A61P1/04
CPC分类号： C07D471/04
摘要： The present invention provides novel compounds of forumula (I) and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in medicine, in particular in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation.
摘要翻译： 本发明提供了新颖的化合物（I）及其在抑制c-Jun N-末端激酶中的用途。 本发明进一步提供这些化合物在药物中的用途，特别是在预防和/或治疗与凋亡和/或炎症相关的神经变性疾病中的用途。
-
2.发明授权Inhibitors of c-Jun N-terminal kinases for the treatment of neurodegenerative disorders relating to apoptosis and/or inflammation 有权用于治疗与凋亡和/或炎症相关的神经变性疾病的c-Jun N-末端激酶抑制剂公开(公告)号：US07645769B2
公开(公告)日：2010-01-12
申请号：US11499334
申请日：2006-08-04
IPC分类号： C07D471/04 , A61K31/4375
CPC分类号： C07D471/04
摘要： The present invention provides novel compounds of formula I and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in medicine, in particular in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation.
摘要翻译： 本发明提供新颖的式I化合物及其在抑制c-Jun N-末端激酶中的用途。 本发明进一步提供这些化合物在药物中的用途，特别是在预防和/或治疗与凋亡和/或炎症相关的神经变性疾病中的用途。
-
公开(公告)号：US07314940B2
公开(公告)日：2008-01-01
申请号：US10473578
申请日：2002-04-04
申请人： Piotr Graczyk , Hirotoshi Numata , Afzal Khan , Vanessa Palmer , Darren Peter Medland , Hitoshi Oinuma , Gurpreet Bhatia
发明人： Piotr Graczyk , Hirotoshi Numata , Afzal Khan , Vanessa Palmer , Darren Peter Medland , Hitoshi Oinuma , Gurpreet Bhatia
IPC分类号： A61K31/4184 , A61K31/4188 , C07D235/02 , C07D519/00 , C07D487/04
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention provides novel compounds of formula I and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in medicine, in particular in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation.
摘要翻译： 本发明提供新颖的式I化合物及其在抑制c-Jun N-末端激酶中的用途。 本发明进一步提供这些化合物在药物中的用途，特别是在预防和/或治疗与凋亡和/或炎症相关的神经变性疾病中的用途。
-
公开(公告)号：US07291630B2
公开(公告)日：2007-11-06
申请号：US10509127
申请日：2003-03-17
IPC分类号： A61K31/437 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention relates to novel 5-substituted 7-azaindole compounds of formula (I), their use in the inhibition of c-Jun N-terminal kinases, their use in medicine and particularly in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation. The invention also provides processes for manufacture of said compounds, compositions containing them and processes for manufacturing such compositions
摘要翻译： 本发明涉及式（I）的新的5-取代的7-氮杂吲哚化合物，其用于抑制c-Jun N-末端激酶，其在医学中的用途，特别是在预防和/或治疗相关的神经变性疾病中 凋亡和/或炎症。 本发明还提供了用于制备所述化合物的方法，含有它们的组合物和用于制备这种组合物的方法
-
-
-
搜索结果
4 条记录 (耗时 0.022 秒)
