公开(公告)号：US20220248668A1

公开(公告)日：2022-08-11

申请号：US17611234

申请日：2020-05-15

Applicant: Polyamyna Nanotech Inc.

Inventor： Ramesh Kumar Mani ,  Bala Kishan Gorityala

IPC: A01N25/08 ,  A01N33/12 ,  A01N59/20 ,  A01N59/16 ,  A01N63/50 ,  A01N37/22 ,  A01N37/44 ,  A01P1/00

Abstract: Described herein are antimicrobial nanoclay comprising two or more cationic antimicrobials. The nanoclay is a phyllosilicate clay and the two or more cationic antimicrobials are individually selected from the group consisting of a quaternary ammonium compound, a metal ion-containing, a cationic chelating agent, a cationic amino acid-based surfactant, a cationic antibiotic, and a cationic compound having a guanidine moiety. The two or more different antimicrobials are incorporated into the nanoclay by a cationic exchange process. Also described are methods for preparing such antimicrobial nanoclays. The antimicrobial nanoclays may be used for conferring antimicrobial activity to an article of manufacture and/or for providing antimicrobial activity to a surface.

公开(公告)号：US20230295231A1

公开(公告)日：2023-09-21

申请号：US18178143

申请日：2023-03-03

Applicant: Polyamyna Nanotech Inc.

Inventor： Frank Schweizer ,  Ronald Domalaon

IPC: C07K7/06 ,  A61K31/496 ,  A61K31/65 ,  A61K38/08

CPC classification number: C07K7/06 ,  A61K31/496 ,  A61K31/65 ,  A61K38/08

Abstract: We evaluated the antibacterial activity of synthetic short proline-rich lipopeptides (SPRLPs) against clinically-relevant Gram-positive and Gram-negative pathogens. The short peptide sequence of SPRLPs were inspired by the repeating PXP motif apparent in longer PRAMPs. We assessed the potential of these SPRLPs to serve as adjuvants in combination with clinically-used antibiotics against P. aeruginosa. Our results revealed an amphiphilic non-hemolytic non-cytotoxic L-lipopeptide lead sequence that strongly potentiates minocycline and rifampicin against MDR/XDR P. aeruginosa. Furthermore, the adjuvant potency is retained in its enantiomeric D-SPRLP counterpart.