公开(公告)号：US08536330B2

公开(公告)日：2013-09-17

申请号：US13642209

申请日：2011-04-21

申请人： Vishwesh Pravinchandra Pandya ,  Santosh Richhariya ,  Prabhakar Divya ,  Hashim Nizar Poovanathil Nagoor Meeran ,  Neera Tewari

发明人： Vishwesh Pravinchandra Pandya ,  Santosh Richhariya ,  Prabhakar Divya ,  Hashim Nizar Poovanathil Nagoor Meeran ,  Neera Tewari

IPC分类号： C07D417/12

CPC分类号： C07D417/12 ,  C07D239/26

摘要： The present invention provides a process for preparing novel intermediates of Formula wherein, R1 can be hydrogen, C1-C4 alkyl, halogen, nitro, hydroxy, or C1-C4 alkoxy; Rx can be selected from hydrophobic residue of HMG-CoA reductase inhibitors; which can be effectively used for the preparation of HMG-CoA reductase inhibitors such as rosuvastatin and pharmaceutically acceptable salts thereof.

摘要翻译： 本发明提供一种制备新型中间体的方法，其中R 1可以是氢，C 1 -C 4烷基，卤素，硝基，羟基或C 1 -C 4烷氧基; Rx可以选自HMG-CoA还原酶抑制剂的疏水残基; 其可以有效地用于HMG-CoA还原酶抑制剂如罗苏伐他汀及其药学上可接受的盐的制备。

公开(公告)号：US20130150579A1

公开(公告)日：2013-06-13

申请号：US13642209

申请日：2011-04-21

申请人： Vishwesh Pravinchandra Pandya ,  Santosh Richhariya ,  Prabhakar Divya ,  Hashim Nizar Poovanathil Nagoor Meeran ,  Neera Tewari

发明人： Vishwesh Pravinchandra Pandya ,  Santosh Richhariya ,  Prabhakar Divya ,  Hashim Nizar Poovanathil Nagoor Meeran ,  Neera Tewari

IPC分类号： C07D417/12 ,  C07D239/26

CPC分类号： C07D417/12 ,  C07D239/26

摘要： The present invention provides a process for preparing novel intermediates of Formula wherein, R1 can be hydrogen, C1-C4 alkyl, halogen, nitro, hydroxy, or C1-C4 alkoxy; Rx can be selected from hydrophobic residue of HMG-CoA reductase inhibitors; which can be effectively used for the preparation of HMG-CoA reductase inhibitors such as rosuvastatin and pharmaceutically acceptable salts thereof.

摘要翻译： 本发明提供一种制备新型中间体的方法，其中R 1可以是氢，C 1 -C 4烷基，卤素，硝基，羟基或C 1 -C 4烷氧基; Rx可以选自HMG-CoA还原酶抑制剂的疏水残基; 其可以有效地用于HMG-CoA还原酶抑制剂如罗苏伐他汀及其药学上可接受的盐的制备。