Mammalian retrotransposable elements
    1.
    发明申请
    Mammalian retrotransposable elements 审中-公开
    哺乳动物反转录转座元件

    公开(公告)号:US20070037759A1

    公开(公告)日:2007-02-15

    申请号:US10544458

    申请日:2004-02-06

    IPC分类号: A61K48/00 C12N15/74

    摘要: The invention relates to a modified retrotransposable element wherein one or more polyadenylation sites have been removed from within the genes of the retrotransposable element, and methods of use thereof. Sequences of optimized retrotransposable element are provided that have polyadenylation sites removed, and may be further modified to optimize codon usage for expression in mammals and to add restriction enzyme sites for ease of use.

    摘要翻译: 本发明涉及一种修饰的反转录可转移元件,其中一个或多个聚腺苷酸化位点已经从反转录转座因子的基因内被去除,及其使用方法。 提供具有去除多腺苷酸化位点的优化的反转录可转移元件的序列,并且可以进一步修饰以优化在哺乳动物中表达的密码子使用并添加限制酶位点以便于使用。