公开(公告)号：US5712369A

公开(公告)日：1998-01-27

申请号：US597495

申请日：1996-02-02

申请人： Lloyd J. Old ,  Sydney Welt ,  Gerd Ritter ,  Richard J. Simpson ,  Edouard Nice ,  R. L. Moritz ,  B. Catimel ,  Hong Ji ,  Anthony W. Burgess ,  Joan K. Heath ,  Sara J. White ,  Cameron Johnstone

发明人： Lloyd J. Old ,  Sydney Welt ,  Gerd Ritter ,  Richard J. Simpson ,  Edouard Nice ,  R. L. Moritz ,  B. Catimel ,  Hong Ji ,  Anthony W. Burgess ,  Joan K. Heath ,  Sara J. White ,  Cameron Johnstone

IPC分类号： C07K14/47 ,  C07K14/705 ,  C07K16/30 ,  C07K14/00 ,  A61K38/00 ,  A61K39/00 ,  A61K39/38

CPC分类号： C07K16/3046 ,  C07K14/47 ,  C07K14/705

摘要： This invention relates to isolated protein and to peptides which are found on the surface of colon cells and colon cancer cells, as well as to nucleic acid molecules encoding said protein and peptides. The protein and peptides bind to tumor-associated antibodies, such as mAb A33. The monomeric protein has a molecular weight of about 43 kD as determined by SDS gel electrophoresis under non-reducing conditions. In addition, this invention relates to the use of said nucleic acid molecules, protein, in monomeric or multimeric form, and to antibodies to said peptides in diagnostic, screening and therapeutic methods. This invention further relates to antibodies specific for said protein, in monomeric or multimeric form, and to antibodies to said peptides.

摘要翻译： 本发明涉及分离的蛋白质和在结肠细胞和结肠癌细胞的表面上发现的肽，以及编码所述蛋白质和肽的核酸分子。 蛋白质和肽结合肿瘤相关抗体，如mAb A33。 单体蛋白质在非还原条件下通过SDS凝胶电泳测定的分子量为约43kD。 此外，本发明涉及在诊断，筛选和治疗方法中所述核酸分子，蛋白质，单体或多聚体形式以及所述肽的抗体的用途。 本发明还涉及以单体或多聚体形式对所述蛋白质特异性的抗体以及针对所述肽的抗体。

公开(公告)号：US06291235B1

公开(公告)日：2001-09-18

申请号：US09068051

申请日：1998-12-10

申请人： Sydney Welt ,  Sara White ,  Cameron Johnstone ,  Lloyd J Old ,  Gerd Ritter ,  Bruno Catimel ,  Hong Ji ,  Antony Burgess ,  Joan Heath ,  Richard J Simpson ,  Edouard Nice ,  R. L Moritz

发明人： Sydney Welt ,  Sara White ,  Cameron Johnstone ,  Lloyd J Old ,  Gerd Ritter ,  Bruno Catimel ,  Hong Ji ,  Antony Burgess ,  Joan Heath ,  Richard J Simpson ,  Edouard Nice ,  R. L Moritz

IPC分类号： C12N1563

CPC分类号： C07K16/3046 ,  C07K14/47 ,  C07K14/705

摘要： This invention relates to isolated proteins and to peptides which are found on the surface of colon cells and colon cancer cells, as well as to nucleic acid molecules encoding said protein and peptides. The protein and peptides bind to tumor associated antibodies, such as mAb 33. The monomeric protein has a molecular weight of about 43 kD as determined by SDS gel electrophoresis under non-reducing conditions. In addition, this invention relates to the use of said nucleic acid molecules, protein, in monomeric or multimeric form, and to antibodies to said peptides in diagnostic, screening and therapeutic methods. This invention further relates to antibodies specific for said protein, in monomeric or multimeric form, and to antibodies to said peptides.

摘要翻译： 本发明涉及分离的蛋白质和在结肠细胞和结肠癌细胞表面上发现的肽，以及编码所述蛋白质和肽的核酸分子。 蛋白质和肽结合肿瘤相关抗体，例如mAb 33.单体蛋白质在非还原条件下通过SDS凝胶电泳测定的分子量为约43kD。 此外，本发明涉及在诊断，筛选和治疗方法中所述核酸分子，蛋白质，单体或多聚体形式以及所述肽的抗体的用途。 本发明还涉及以单体或多聚体形式对所述蛋白质特异性的抗体以及针对所述肽的抗体。