公开(公告)号：US12298300B2

公开(公告)日：2025-05-13

申请号：US17232631

申请日：2021-04-16

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  RECOGNITION ANALYTIX INC.

Inventor： Stuart Lindsay ,  Karen Anderson ,  Mark Knappenberger ,  Sepideh Afsari Mamaghani ,  Jacob L. Swett

IPC: G01N33/53 ,  C12N9/22 ,  C12N15/11 ,  G01N27/02

Abstract: The present disclosure provides devices, systems, and methods related to single molecule detection. In particular, the present disclosure provides devices and methods for sequence-specific detection of a nucleic acid target using current fluctuations as a readout for protein binding to the nucleic acid target. As described herein, certain aspects of the bioelectronic devices and method can be used to detect and identify any nucleic acid target for the purpose of diagnosis and/or treatment.

公开(公告)号：US11808755B2

公开(公告)日：2023-11-07

申请号：US17055771

申请日：2019-05-16

Applicant: RECOGNITION ANALYTIX, INC.

Inventor： Stuart Lindsay ,  Peiming Zhang

IPC: G01N33/487 ,  C12Q1/00 ,  G01N27/414

CPC classification number: G01N33/48721 ,  C12Q1/005 ,  G01N27/4146

Abstract: The present disclosure relates to a device, system and method for sensing functional motions of a single protein molecule via direct attachment of one or more electrodes to the molecule. The present disclosure also relates to an array, a system comprising an array and method for sequencing a biopolymer using an array.

公开(公告)号：US20220196596A1

公开(公告)日：2022-06-23

申请号：US17559529

申请日：2021-12-22

Applicant: RECOGNITION ANALYTIX, INC.

Inventor： Jacob Swett

IPC: G01N27/447 ,  B03C5/00

Abstract: The present disclosure provides devices, systems, and methods related to protein bioelectronics. In particular, the present disclosure provides devices, systems, and methods for manipulating a protein-of-interest into a target position within two electrodes in order to generate a functional bioelectronic circuit. The present disclosure also provides devices, systems, and methods for selectively attracting and concentrating one or more target analytes to the protein-of-interest, which can be used to develop analytical platforms to detect and measure various characteristics of protein function.

公开(公告)号：US20210325379A1

公开(公告)日：2021-10-21

申请号：US17232631

申请日：2021-04-16

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  RECOGNITION ANALYTIX INC.

Inventor： Stuart Lindsay ,  Karen Anderson ,  Mark Knappenberger ,  Sepideh Afsari Mamaghani ,  Jacob L. Swett

IPC: G01N33/53 ,  C12N15/11 ,  C12N9/22 ,  G01N27/02

Abstract: The present disclosure provides devices, systems, and methods related to single molecule detection. In particular, the present disclosure provides devices and methods for sequence-specific detection of a nucleic acid target using current fluctuations as a readout for protein binding to the nucleic acid target. As described herein, certain aspects of the bioelectronic devices and method can be used to detect and identify any nucleic acid target for the purpose of diagnosis and/or treatment.

公开(公告)号：US20240159734A1

公开(公告)日：2024-05-16

申请号：US18468210

申请日：2023-09-15

Applicant: RECOGNITION ANALYTIX, INC.

Inventor： Stuart Lindsay ,  Peiming ZHANG

IPC: G01N33/487 ,  C12Q1/00 ,  G01N27/414

CPC classification number: G01N33/48721 ,  C12Q1/005 ,  G01N27/4146

Abstract: The present disclosure relates to a device, system and method for sensing functional motions of a single protein molecule via direct attachment of one or more electrodes to the molecule. The present disclosure also relates to an array, a system comprising an array and method for sequencing a biopolymer using an array.