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公开(公告)号：US11977067B2
公开(公告)日：2024-05-07
申请号：US18187983
申请日：2023-03-22
申请人： Radius Health, Inc.
发明人： Greg Williams , Naveen Palwai , David Hanley
摘要： Provided herein are newly discovered methods of analyzing abaloparatide samples for abaloparatide isomers. Additionally, methods of storing and treating with abaloparatide in view of the newly discovered abaloparatide isomers are described.
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公开(公告)号：US20240139290A1
公开(公告)日：2024-05-02
申请号：US18405807
申请日：2024-01-05
申请人： Radius Health, Inc.
摘要： Disclosed herein is a method of treating cardiomyocyte reperfusion injury associated with an ischemic myocardial event. The method includes administering to a subject in need thereof an effective amount of a abaloparatide to a subject in need thereof prior to performing reperfusion, concurrent with performing reperfusion, or both. Further provided is a method of treating cardiomyocyte reperfusion injury associated with cardiac transplant. The method includes contacting a donor heart with an effective amount of abaloparatide.
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公开(公告)号：US11806387B1
公开(公告)日：2023-11-07
申请号：US18320544
申请日：2023-05-19
申请人： Radius Health, Inc.
发明人： Matt Burke , Silvio Campagna
IPC分类号： C07K1/06 , C07K14/635 , A61K38/29 , C07K1/04 , C07K1/08
摘要： Disclosed herein is an improved process for preparing abaloparatide. The process generally utilizes solid phase peptide synthesis employing an Fmoc-protection scheme. Incorporating a systematic recoupling step of a glutamine residue (Gln16) has been found to minimize the formation of an undesirable des-Gln16 abaloparatide impurity, which is often obtained in significant quantities in the conventional process.
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公开(公告)号：US11680942B2
公开(公告)日：2023-06-20
申请号：US17571312
申请日：2022-01-07
申请人： Radius Health, Inc.
发明人： Heidi K. Chandler
IPC分类号： G01N33/50
CPC分类号： G01N33/5032 , G01N2333/635
摘要： The present disclosure is directed to methods (e.g., in vitro methods) for detecting the presence of neutralizing antibodies to PTH or PTHrP analog in a sample. The in vitro method comprises the steps of obtaining a sample from a subject; contacting the sample with a cell; measuring cyclic adenosine monophosphate (cAMP) levels; and detecting the presence of neutralizing antibodies when cAMP levels are reduced relative to a negative control sample without neutralizing antibodies. An in vitro method of detecting the presence of neutralizing antibodies in a sample from a subject treated with Abaloparatide, is also provided. Further provided herein is a kit for carrying out the methods described herein comprising components required to carry out the obtaining, contacting, measuring and detecting steps and instructions for use.
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公开(公告)号：US20220378881A1
公开(公告)日：2022-12-01
申请号：US17824256
申请日：2022-05-25
申请人： Radius Health, Inc.
发明人： Elena Nikonova , Yamei Wang
摘要： Disclosed herein is a method for preventing or reducing bone fractures in an overweight subject. The method comprises administering to the subject a therapeutically effective amount of an osteoanabolic agent.
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公开(公告)号：US20210389300A1
公开(公告)日：2021-12-16
申请号：US17369163
申请日：2021-07-07
申请人： Radius Health, Inc.
发明人： Heidi K. Chandler
IPC分类号： G01N33/50
摘要： The present disclosure is directed to methods (e.g., in vitro methods) for detecting the presence of neutralizing antibodies to PTH or PTHrP analog in a sample. The in vitro method comprises the steps of obtaining a sample from a subject; contacting the sample with a cell; measuring cyclic adenosine monophosphate (cAMP) levels; and detecting the presence of neutralizing antibodies when cAMP levels are reduced relative to a negative control sample without neutralizing antibodies. An in vitro method of detecting the presence of neutralizing antibodies in a sample from a subject treated with Abaloparatide, is also provided. Further provided herein is a kit for carrying out the methods described herein comprising components required to carry out the obtaining, contacting, measuring and detecting steps and instructions for use.
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公开(公告)号：US20200061160A1
公开(公告)日：2020-02-27
申请号：US16566499
申请日：2019-09-10
申请人： Radius Health, Inc.
发明人： Gary Hattersley
摘要： Disclosed herein are PTHrP or analogues thereof, such as abaloparatide, for preventing or reducing bone fractures in subjects in need thereof, as well as methods of using PTHrP or analogues thereof to prevent or reduce bone fractures. Also disclosed are PTHrP or analogues thereof, such as abaloparatide, for increasing BMD and/or TBS in subjects in need thereof, as well as methods of using PTHrP or analogues thereof to increase BMD and/or TBS.
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公开(公告)号：US09555014B2
公开(公告)日：2017-01-31
申请号：US14281475
申请日：2014-05-19
申请人： Radius Health, Inc.
IPC分类号： A61K31/135 , A01N33/02 , A61K31/137 , A61K9/48
CPC分类号： A61K31/137 , A61K9/485 , A61K9/4866
摘要： This invention relates to clinically useful therapeutic regimens comprising the administration of (R)-6-(2-(ethyl(4-(2-(ethylamino)ethyl)benzyl)amino)-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-ol.
摘要翻译： 本发明涉及临床有用的治疗方案，其包括施用（R）-6-（2-（乙基（4-（2-（乙基氨基）乙基）苄基）氨基）-4-甲氧基苯基）-5,6,7， 8-四氢萘-2-醇。
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公开(公告)号：US20140046293A1
公开(公告)日：2014-02-13
申请号：US13791360
申请日：2013-03-08
申请人： Radius Health, Inc. , 3M Innovative Properties Company, a wholly owned subsidiary of 3M Company
发明人： Gary Hattersley , Kris J. Hansen , Amy S. Determan , Ying Zhang
摘要： The present invention provides compositions, devices, methods and processes related to the intradermal delivery of PTHrP and PTHrP analogues, particularly [Glu22,25, Leu23,28,31, Aib29, Lys26,30]hPTHrP(1-34)NH2.
摘要翻译： 本发明提供了与皮内递送PTHrP和PTHrP类似物，特别是[Glu22,25，Leu23,28,31，Aib29，Lys26,30] hPTHrP（1-34）NH2相关的组合物，装置，方法和方法。
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公开(公告)号：US20240342252A1
公开(公告)日：2024-10-17
申请号：US18438207
申请日：2024-02-09
申请人： Radius Health, Inc.
发明人： Matt Burke , Silvio Campagna
IPC分类号： A61K38/29 , C07K1/04 , C07K1/06 , C07K1/08 , C07K14/635
摘要： Disclosed herein is an improved process for preparing abaloparatide. The process generally utilizes solid phase peptide synthesis employing an Fmoc-protection scheme. Incorporating a systematic recoupling step of a glutamine residue (Gln16) has been found to minimize the formation of an undesirable des-Gln16 abaloparatide impurity, which is often obtained in significant quantities in the conventional process.
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