公开(公告)号：US07994144B2

公开(公告)日：2011-08-09

申请号：US10483347

申请日：2002-07-10

申请人： Geoffrey P. Symonds ,  Rafael Amado ,  Lun-Quan Sun ,  Janet Macpherson ,  Greg Fanning ,  Wayne Gerlach

发明人： Geoffrey P. Symonds ,  Rafael Amado ,  Lun-Quan Sun ,  Janet Macpherson ,  Greg Fanning ,  Wayne Gerlach

IPC分类号： A01N43/04 ,  C12N5/08 ,  C12N15/63 ,  C12Q1/68 ,  C07H21/04

CPC分类号： A61K48/00 ,  A61K38/00 ,  A61K2035/124 ,  C12N15/1132 ,  C12N2310/111 ,  C12N2310/121 ,  C12N2310/14

摘要： Described are compositions and methods relating to gene therapy, particularly as applied to hematopoietic progenitor (HP) cells, to transduced cells and methods of obtaining them, and to methods of using them to provide prolonged engraftment of modified hematopoietic cells in human subjects. The invention particularly relates to ex vivo gene therapy of HP cells for treatment or prevention of HIV infection.

摘要翻译： 描述了与基因治疗有关的组合物和方法，特别是应用于造血祖细胞（HP）细胞的转导细胞和获得它们的方法，以及使用它们在人受试者中延长植入修饰的造血细胞的方法。 本发明特别涉及用于治疗或预防HIV感染的HP细胞的离体基因治疗。

公开(公告)号：US20080044394A1

公开(公告)日：2008-02-21

申请号：US11506722

申请日：2006-08-18

申请人： Geoffrey Symonds ,  Rafael Amado ,  Lun-Quan Sun ,  Janet MacPherson ,  Gregory Fanning ,  Wayne Gerlach

发明人： Geoffrey Symonds ,  Rafael Amado ,  Lun-Quan Sun ,  Janet MacPherson ,  Gregory Fanning ,  Wayne Gerlach

IPC分类号： A61K48/00

CPC分类号： C12N15/1132 ,  A61K38/00 ,  A61K48/00 ,  A61K2035/124 ,  C12N2310/111 ,  C12N2310/121 ,  C12N2310/14

摘要： Described are compositions and methods relating to gene therapy, particularly as applied to hematopoietic progenitor (HP) cells, to transduced cells and methods of obtaining them, and to methods of using them to provide prolonged engraftment of modified hematopoietic cells in human subjects. The invention particularly relates to ex vivo gene therapy of HP cells for treatment or prevention of HIV infection.

摘要翻译： 描述了与基因治疗有关的组合物和方法，特别是应用于造血祖细胞（HP）细胞的转导细胞和获得它们的方法，以及使用它们在人受试者中延长植入修饰的造血细胞的方法。 本发明特别涉及用于治疗或预防HIV感染的HP细胞的离体基因治疗。

公开(公告)号：US20130344040A1

公开(公告)日：2013-12-26

申请号：US13936781

申请日：2013-07-08

申请人： Geoffrey P. Symonds ,  Rafael Amado ,  Lun-Quan Sun ,  Janet Macpherson ,  Greg Fanning ,  Wayne Gerlach

发明人： Geoffrey P. Symonds ,  Rafael Amado ,  Lun-Quan Sun ,  Janet Macpherson ,  Greg Fanning ,  Wayne Gerlach

IPC分类号： A61K48/00

CPC分类号： A61K48/00 ,  A61K38/00 ,  A61K2035/124 ,  C12N15/1132 ,  C12N2310/111 ,  C12N2310/121 ,  C12N2310/14

摘要： Described are compositions and methods relating to gene therapy, particularly as applied to hematopoietic progenitor (HP) cells, to transduced cells and methods of obtaining them, and to methods of using them to provide prolonged engraftment of modified hematopoietic cells in human subjects. The invention particularly relates to ex vivo gene therapy of HP cells for treatment or prevention of HIV infection.

摘要翻译： 描述了与基因治疗有关的组合物和方法，特别是应用于造血祖细胞（HP）细胞的转导细胞和获得它们的方法，以及使用它们在人受试者中延长植入修饰的造血细胞的方法。 本发明特别涉及用于治疗或预防HIV感染的HP细胞的离体基因治疗。

公开(公告)号：US20170120878A1

公开(公告)日：2017-05-04

申请号：US14932625

申请日：2015-11-04

申请人： Rafael Amado

发明人： Rafael Amado

IPC分类号： B60S3/04 ,  B25G1/04

CPC分类号： B60S3/045 ,  B25G1/04 ,  E04D13/106

摘要： An overhead snow moving device for moving snow positioned overhead includes a plurality of rods. Each rod has a first end and a second end, and comprises a plurality of nested sections. Supports are coupled to and extend between the rods proximate to top ends of the nested sections. A strut is coupled to and extends between the rods proximate to the first ends of the rods. First couplers are positioned proximate to the top ends of the nested sections. Second couplers, complimentary to the first couplers, are positioned proximate to bottom ends of the nested sections. Each of a plurality of extenders is angularly coupled to and extends from a respective second end of a rod. A plow is coupled to each of the extenders distally from the second ends of the rods.

公开(公告)号：US20120058092A1

公开(公告)日：2012-03-08

申请号：US13206301

申请日：2011-08-09

申请人： Geoffrey P. Symonds ,  Rafael Amado ,  Lun-Quan Sun ,  Janet Macpherson ,  Greg Fanning ,  Wayne Gerlach

发明人： Geoffrey P. Symonds ,  Rafael Amado ,  Lun-Quan Sun ,  Janet Macpherson ,  Greg Fanning ,  Wayne Gerlach

IPC分类号： A61K48/00 ,  A61P31/18

CPC分类号： A61K48/00 ,  A61K38/00 ,  A61K2035/124 ,  C12N15/1132 ,  C12N2310/111 ,  C12N2310/121 ,  C12N2310/14

摘要： Described are compositions and methods relating to gene therapy, particularly as applied to hematopoietic progenitor (HP) cells, to transduced cells and methods of obtaining them, and to methods of using them to provide prolonged engraftment of modified hematopoietic cells in human subjects. The invention particularly relates to ex vivo gene therapy of HP cells for treatment or prevention of HIV infection.

摘要翻译： 描述了与基因治疗有关的组合物和方法，特别是应用于造血祖细胞（HP）细胞的转导细胞和获得它们的方法，以及使用它们在人受试者中延长植入修饰的造血细胞的方法。 本发明特别涉及用于治疗或预防HIV感染的HP细胞的离体基因治疗。

公开(公告)号：US09616857B1

公开(公告)日：2017-04-11

申请号：US14932625

申请日：2015-11-04

申请人： Rafael Amado

发明人： Rafael Amado

IPC分类号： E04D13/10 ,  B60S3/04 ,  B25G1/04 ,  E01H5/02

CPC分类号： B60S3/045 ,  B25G1/04 ,  E04D13/106

摘要： An overhead snow moving device for moving snow positioned overhead includes a plurality of rods. Each rod has a first end and a second end, and comprises a plurality of nested sections. Supports are coupled to and extend between the rods proximate to top ends of the nested sections. A strut is coupled to and extends between the rods proximate to the first ends of the rods. First couplers are positioned proximate to the top ends of the nested sections. Second couplers, complimentary to the first couplers, are positioned proximate to bottom ends of the nested sections. Each of a plurality of extenders is angularly coupled to and extends from a respective second end of a rod. A plow is coupled to each of the extenders distally from the second ends of the rods.