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    Ribozymes targeting the MoMLV PSI packaging sequence and the HIV tat sequence
    2.
    发明授权
    Ribozymes targeting the MoMLV PSI packaging sequence and the HIV tat sequence 失效
    靶向MoMLV PSI包装序列的核酶和HIV tat序列

    公开(公告)号：US6114167A

    公开(公告)日：2000-09-05

    申请号：US310259

    申请日：1994-09-21

    Applicant: Geoffrey P. Symonds ,  Lun-Quan Sun

    Inventor： Geoffrey P. Symonds ,  Lun-Quan Sun

    IPC: A61K38/00 ,  C12N15/113 ,  C12N5/10

    CPC classification number: C12N15/113 ,  C12N15/1131 ,  C12N15/1132 ,  A61K38/00 ,  C12N2310/111 ,  C12N2310/121

    Abstract: A cell comprising a synthetic non-naturally occurring oligonucleotide compound comprises nucleotides whose sequence defines a conserved catalytic region and nucleotides whose sequence hybridizes with a predetermined target sequence within a MoMLV Psi packaging sequence on the HIV tat sequence. The catalytic region may be derived from a hammerhead ribozyme, a hairpin ribozyme a hepatitis delta ribozyme, an PNAase P ribozyme, a group I intron or a group II intron.

    Abstract translation: 包含合成的非天然存在的寡核苷酸化合物的细胞包含其序列定义保守催化区域的核苷酸和其序列与HIV tat序列上的MoMLV Psi包装序列内的预定靶序列杂交的核苷酸。 催化区域可衍生自锤头核酶，发夹核酶，戊型肝炎核酶，PNAase P核酶，I组内含子或II组内含子。

    Ribozymes targeting retroviral packaging sequence expression constructs and recombinant retroviruses containing such constructs
    5.
    发明授权
    Ribozymes targeting retroviral packaging sequence expression constructs and recombinant retroviruses containing such constructs 失效
    针对逆转录病毒包装序列表达构建体和含有此类构建体的重组逆转录病毒的核酶

    公开(公告)号：US5712384A

    公开(公告)日：1998-01-27

    申请号：US178082

    申请日：1994-01-05

    Applicant: Geoffrey P. Symonds ,  Lun-Quan Sun

    Inventor： Geoffrey P. Symonds ,  Lun-Quan Sun

    IPC: A61K38/00 ,  C12N15/113 ,  C12Q1/68 ,  A61K48/00 ,  C07H21/04

    CPC classification number: C12N15/113 ,  C12N15/1131 ,  C12N15/1132 ,  A61K38/00 ,  C12N2310/111 ,  C12N2310/121

    Abstract: This invention is directed to a synthetic non-naturally occurring oligonucleotide compound which comprises nucleotides whose sequence defines a conserved catalytic region and nucleotides whose sequence is capable of hybridizing with a predetermined target sequence within a packaging sequence of an RNA virus. Preferably, the viral packaging sequence is a retrovirus packaging sequence or the HIV-1 Psi packaging sequence. The RNA virus may be HIV-1, Feline Leukemia Virus, Feline Immunodeficiency Virus or one of the viruses listed in Table I. The conserved catalytic region may be derived from a hammerhead ribozyme, a hairpin ribozyme, a hepatitis delta ribozyme, an RNAase P ribozyme, a group I intron, a group II intron. The invention is also directed to multiple ribozymes, combinations of ribozymes, with or without antisense, and combinations of ribozymes, with antisense, and TAR decoys, poly TARs or RRE decoys targeted against the RNA virus and combinations of ribozymes and antisense targetted against the RNA virus. Vectors are also described. Further, methods of treatment and methods of use both in vivo and ex vivo are described.

    Abstract translation: 本发明涉及合成的非天然存在的寡核苷酸化合物，其包含其序列限定保守催化区的核苷酸和其序列能够与RNA病毒的包装序列内的预定靶序列杂交的核苷酸。 优选地，病毒包装序列是逆转录病毒包装序列或HIV-1 Psi包装序列。 RNA病毒可以是HIV-1，猫白血病病毒，猫免疫缺陷病毒或表I中列出的病毒之一。保守的催化区域可以衍生自锤头核酶，发夹核酶，乙型肝炎核酶，RNA酶P 核酶，I组内含子，II组内含子。 本发明还涉及多种核酶，具有或不具有反义的核酶的组合，以及具有反义和TAR诱饵的核酶的组合，针对RNA病毒靶向的多TAR或RRE诱饵以及针对RNA的核酶和反义核酸的组合 病毒。 还描述了载体。 此外，描述了体内和体外的治疗方法和使用方法。

    COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFLUENZA INFECTION
    9.
    发明申请
    COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFLUENZA INFECTION 有权
    用于治疗感染感染的组合物和方法

    公开(公告)号：US20070166801A1

    公开(公告)日：2007-07-19

    申请号：US11458378

    申请日：2006-07-18

    Applicant: Roderic M.K. Dale ,  Lun-Quan Sun

    Inventor： Roderic M.K. Dale ,  Lun-Quan Sun

    IPC: C12Q1/68 ,  C12P19/34

    CPC classification number: C12N15/1131 ,  A61K38/00 ,  A61K39/145 ,  C07K14/005 ,  C12N2310/11 ,  C12N2310/321 ,  C12N2320/32 ,  C12Q1/701

    Abstract: The invention provides compositions of oligonucleotides targeted at influenza genes and at host animal genes involved in response to influenza infection. In some embodiments, the oligonucleotides are modified. In some embodiments, the compositions contain one, or more than one, oligonucleotide. The invention also provides methods and kits using the compositions of the invention for the treatment and prevention of influenza.

    Abstract translation: 本发明提供了靶向流感基因的寡核苷酸组合物和涉及流感感染的宿主动物基因。 在一些实施方案中，寡核苷酸被修饰。 在一些实施方案中，组合物含有一种或多于一种的寡核苷酸。 本发明还提供了使用本发明组合物治疗和预防流感的方法和试剂盒。

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