公开(公告)号：US06238668B1

公开(公告)日：2001-05-29

申请号：US09042280

申请日：1998-01-13

申请人： Samuel J. Danishefsky ,  Prashant P. Deshpande ,  In Jong Kim ,  Philip Livingston ,  Hyun Jin Kim ,  Ragupathi Govindaswami ,  Tae Kyo Park

发明人： Samuel J. Danishefsky ,  Prashant P. Deshpande ,  In Jong Kim ,  Philip Livingston ,  Hyun Jin Kim ,  Ragupathi Govindaswami ,  Tae Kyo Park

IPC分类号： A61K3900

CPC分类号： C07H15/10 ,  A61K47/643 ,  A61K47/646

摘要： The present invention provides processes for the preparation of the KH-1 and N3 antigens, as well as related analgoues thereof, which are useful as anticancer therapeutics. The present invention also provides various intermediates useful in the preparation of KH-1 and N3 and analogues thereof. Additionally, the invention provides various compositions comprising any of the analogues of KH-1 and N3 available through the methods of the invention and pharmaceutical carriers useful in the treatment of subjects suffering from various forms of epithelial cancer.

摘要翻译： 本发明提供了可用作抗癌治疗剂的KH-1和N3抗原的制备方法及其相关的方法。 本发明还提供了可用于制备KH-1和N 3的各种中间体及其类似物。 此外，本发明提供了包含可通过本发明方法获得的任何类似物的KH-1和N 3的各种组合物和可用于治疗患有各种形式的上皮癌的受试者的药物载体。