公开(公告)号：US07951060B2

公开(公告)日：2011-05-31

申请号：US12792005

申请日：2010-06-02

申请人： Charles E. Larsen ,  Richard A. Hillstead ,  Roelof Trip ,  Eugene de Juan ,  Mark Humayun ,  Eberhard Fritz ,  Rainer Pintaske

发明人： Charles E. Larsen ,  Richard A. Hillstead ,  Roelof Trip ,  Eugene de Juan ,  Mark Humayun ,  Eberhard Fritz ,  Rainer Pintaske

IPC分类号： A61N5/00

CPC分类号： A61N5/1017

摘要： A method for performing intraocular brachytherapy and an apparatus for performing the same is disclosed. The apparatus preferably comprises a hand-held delivery device that advances a radiation source into an associated cannula or probe that is positioned adjacent the target tissue. The handpiece provides for shielded storage of the radiation source when retracted from the cannula and includes a slider mechanism for advancing and retracting the radiation source. The radiation source is mounted to a wire that has a flexible distal end and a relatively stiffer proximal end. A positioning system for the cannula is also disclosed.

摘要翻译： 公开了一种用于进行眼内近距离放射治疗的方法及其执行装置。 该装置优选地包括将辐射源前进到与靶组织相邻定位的相关套管或探针中的手持递送装置。 所述手持件在从套管缩回时提供辐射源的屏蔽存储，并且包括用于前进和后退辐射源的滑块机构。 辐射源安装到具有柔性远端和较硬的近端的导线上。 还公开了用于套管的定位系统。

公开(公告)号：US20070118010A1

公开(公告)日：2007-05-24

申请号：US11559958

申请日：2006-11-15

申请人： Richard Hillstead ,  Charles Larsen ,  Roelof Trip ,  Cory Anderson ,  Eberhard Fritz ,  Rainer Pintaske ,  John Hendrick ,  Benjamin Woodward

发明人： Richard Hillstead ,  Charles Larsen ,  Roelof Trip ,  Cory Anderson ,  Eberhard Fritz ,  Rainer Pintaske ,  John Hendrick ,  Benjamin Woodward

IPC分类号： A61N5/00 ,  A61B5/05 ,  A61B8/00

CPC分类号： A61N5/1017 ,  A61N5/1007 ,  A61N5/1049 ,  A61N2005/1058

摘要： Methods and apparatus for intraocular brachytherapy are disclosed in which a cannula is introduced into the eye for delivery of radiation to a target tissue. Techniques for properly locating the cannula with respect to the target tissue, for protecting non-target tissue, for regulating heat generated by x-ray emitters, and for combining therapies are disclosed.

摘要翻译： 公开了用于眼内近距离放射治疗的方法和装置，其中将插管引入眼睛以将辐射递送至靶组织。 公开了用于相对于目标组织适当地定位插管的技术，用于保护非目标组织，用于调节由x射线发射器产生的热量和用于组合疗​​法。

公开(公告)号：US07563222B2

公开(公告)日：2009-07-21

申请号：US11228030

申请日：2005-09-15

申请人： Charles E. Larsen ,  Richard A. Hillstead ,  Roelof Trip ,  Eugene deJuan ,  Mark Humayun ,  Eberhard Fritz ,  Rainer Pintaske

发明人： Charles E. Larsen ,  Richard A. Hillstead ,  Roelof Trip ,  Eugene deJuan ,  Mark Humayun ,  Eberhard Fritz ,  Rainer Pintaske

IPC分类号： A61N5/00

CPC分类号： A61N5/1017 ,  A61N5/1049 ,  A61N2005/1058

摘要： A method for performing intraocular brachytherapy and an apparatus for performing the same is disclosed. The apparatus preferably comprises a hand-held delivery device that advances a radiation source into an associated cannula or probe that is positioned adjacent the target tissue. The handpiece provides for shielded storage of the radiation source when retracted from the cannula and includes a slider mechanism for advancing and retracting the radiation source. The radiation source is mounted to a wire that has a flexible distal end and a relatively stiffer proximal end.

摘要翻译： 公开了一种用于进行眼内近距离放射治疗的方法及其执行装置。 该装置优选地包括将辐射源前进到与靶组织相邻定位的相关套管或探针中的手持递送装置。 所述手持件在从套管缩回时提供辐射源的屏蔽存储，并且包括用于前进和后退辐射源的滑块机构。 辐射源安装到具有柔性远端和较硬的近端的导线上。

公开(公告)号：US20050277802A1

公开(公告)日：2005-12-15

申请号：US11056763

申请日：2005-02-11

申请人： Charles Larsen ,  Richard Hillstead ,  Roelof Trip ,  Eugene de Juan ,  Mark Humayun ,  Eberhard Fritz ,  Rainer Pintaske

发明人： Charles Larsen ,  Richard Hillstead ,  Roelof Trip ,  Eugene de Juan ,  Mark Humayun ,  Eberhard Fritz ,  Rainer Pintaske

IPC分类号： A61N5/00 ,  A61N5/10

CPC分类号： A61N5/1017

摘要： A method for performing intraocular brachytherapy and an apparatus for performing the same is disclosed. The apparatus preferably comprises a hand-held delivery device that advances a radiation source into an associated cannula or probe that is positioned adjacent the target tissue. The handpiece provides for shielded storage of the radiation source when retracted from the cannula and includes a slider mechanism for advancing and retracting the radiation source. The radiation source is mounted to a wire that has a flexible distal end and a relatively stiffer proximal end. A positioning system for the cannula is also disclosed.

摘要翻译： 公开了一种用于进行眼内近距离放射治疗的方法及其执行装置。 该装置优选地包括将辐射源前进到与靶组织相邻定位的相关套管或探针中的手持递送装置。 所述手持件在从套管缩回时提供辐射源的屏蔽存储并且包括用于前进和后退辐射源的滑块机构。 辐射源安装到具有柔性远端和较硬的近端的导线上。 还公开了用于套管的定位系统。

公开(公告)号：US20110021906A1

公开(公告)日：2011-01-27

申请号：US12887996

申请日：2010-09-22

申请人： Richard A. Hillstead ,  Charles E. Larsen ,  Roelof Trip ,  Cory S. Anderson ,  Eberhard Fritz ,  Rainer Pintaske ,  John N. Hendrick ,  Benjamin W. Woodward

发明人： Richard A. Hillstead ,  Charles E. Larsen ,  Roelof Trip ,  Cory S. Anderson ,  Eberhard Fritz ,  Rainer Pintaske ,  John N. Hendrick ,  Benjamin W. Woodward

IPC分类号： A61N5/00 ,  A61B6/00

CPC分类号： A61N5/1017 ,  A61N5/1007 ,  A61N5/1049 ,  A61N2005/1058

摘要： Methods and apparatus for intraocular brachytherapy are disclosed in which a cannula is introduced into the eye for delivery of radiation to a target tissue. Techniques for properly locating the cannula with respect to the target tissue, for protecting non-target tissue, for regulating heat generated by x-ray emitters, and for combining therapies are disclosed.

摘要翻译： 公开了用于眼内近距离放射治疗的方法和装置，其中将插管引入眼睛以将辐射递送至靶组织。 公开了用于相对于目标组织适当地定位插管的技术，用于保护非目标组织，用于调节由x射线发射器产生的热量和用于组合疗​​法。

公开(公告)号：US07744520B2

公开(公告)日：2010-06-29

申请号：US11056763

申请日：2005-02-11

申请人： Charles E. Larsen ,  Richard A. Hillstead ,  Roelof Trip ,  Eugene de Juan ,  Mark Humayun ,  Eberhard Fritz ,  Rainer Pintaske

发明人： Charles E. Larsen ,  Richard A. Hillstead ,  Roelof Trip ,  Eugene de Juan ,  Mark Humayun ,  Eberhard Fritz ,  Rainer Pintaske

IPC分类号： A61N5/00

CPC分类号： A61N5/1017

摘要： A method for performing intraocular brachytherapy and an apparatus for performing the same is disclosed. The apparatus preferably comprises a hand-held delivery device that advances a radiation source into an associated cannula or probe that is positioned adjacent the target tissue. The handpiece provides for shielded storage of the radiation source when retracted from the cannula and includes a slider mechanism for advancing and retracting the radiation source. The radiation source is mounted to a wire that has a flexible distal end and a relatively stiffer proximal end. A positioning system for the cannula is also disclosed.

摘要翻译： 公开了一种用于进行眼内近距离放射治疗的方法及其执行装置。 该装置优选地包括将辐射源前进到与靶组织相邻定位的相关套管或探针中的手持递送装置。 所述手持件在从套管缩回时提供辐射源的屏蔽存储，并且包括用于前进和后退辐射源的滑块机构。 辐射源安装到具有柔性远端和较硬的近端的导线上。 还公开了用于套管的定位系统。

公开(公告)号：US08292795B2

公开(公告)日：2012-10-23

申请号：US12887996

申请日：2010-09-22

申请人： Richard A Hillstead ,  Charles E. Larsen ,  Roelof Trip ,  Cory S. Anderson ,  Eberhard Fritz ,  Rainer Pintaske

发明人： Richard A Hillstead ,  Charles E. Larsen ,  Roelof Trip ,  Cory S. Anderson ,  Eberhard Fritz ,  Rainer Pintaske

IPC分类号： A61M36/00 ,  A61N5/00

CPC分类号： A61N5/1017 ,  A61N5/1007 ,  A61N5/1049 ,  A61N2005/1058

摘要： Methods and apparatus for intraocular brachytherapy are disclosed in which a cannula is introduced into the eye for delivery of radiation to a target tissue. Techniques for properly locating the cannula with respect to the target tissue, for protecting non-target tissue, for regulating heat generated by x-ray emitters, and for combining therapies are disclosed.

摘要翻译： 公开了用于眼内近距离放射治疗的方法和装置，其中将插管引入眼睛以将辐射递送至靶组织。 公开了用于相对于目标组织适当地定位插管的技术，用于保护非目标组织，用于调节由x射线发射器产生的热量和用于组合疗​​法。

公开(公告)号：US20110004045A1

公开(公告)日：2011-01-06

申请号：US12870459

申请日：2010-08-27

申请人： Charles E. Larsen ,  Richard A. Hillstead ,  Roelof Trip ,  Eugene deJuan ,  Mark S. Humayun ,  Eberhard Fritz ,  Rainer Pintaske ,  Sabine Willenkamp ,  Gerd T. Phillipps

发明人： Charles E. Larsen ,  Richard A. Hillstead ,  Roelof Trip ,  Eugene deJuan ,  Mark S. Humayun ,  Eberhard Fritz ,  Rainer Pintaske ,  Sabine Willenkamp ,  Gerd T. Phillipps

IPC分类号： A61M36/12

CPC分类号： A61N5/1017

摘要： A method for performing intraocular brachytherapy and an apparatus for performing the same is disclosed. The apparatus preferably comprises a hand-held delivery device that advances a radiation source into an associated cannula or probe that is positioned adjacent the target tissue. The handpiece provides for shielded storage of the radiation source when retracted from the cannula and includes a slider mechanism for advancing and retracting the radiation source. The radiation source is mounted to a wire that has a flexible distal end and a relatively stiffer proximal end. A positioning system for the cannula is also disclosed.

摘要翻译： 公开了一种用于进行眼内近距离放射治疗的方法及其执行装置。 该装置优选地包括将辐射源前进到与靶组织相邻定位的相关套管或探针中的手持递送装置。 所述手持件在从套管缩回时提供辐射源的屏蔽存储，并且包括用于前进和后退辐射源的滑块机构。 辐射源安装到具有柔性远端和较硬的近端的导线上。 还公开了用于套管的定位系统。

公开(公告)号：US20100268013A1

公开(公告)日：2010-10-21

申请号：US12792005

申请日：2010-06-02

申请人： Charles E. Larsen ,  Richard A. Hillstead ,  Roelof Trip ,  Eugene deJuan ,  Mark Humayun ,  Eberhard Fritz ,  Rainer Pintaske

发明人： Charles E. Larsen ,  Richard A. Hillstead ,  Roelof Trip ,  Eugene deJuan ,  Mark Humayun ,  Eberhard Fritz ,  Rainer Pintaske

IPC分类号： A61M36/04

CPC分类号： A61N5/1017

摘要： A method for performing intraocular brachytherapy and an apparatus for performing the same is disclosed. The apparatus preferably comprises a hand-held delivery device that advances a radiation source into an associated cannula or probe that is positioned adjacent the target tissue. The handpiece provides for shielded storage of the radiation source when retracted from the cannula and includes a slider mechanism for advancing and retracting the radiation source. The radiation source is mounted to a wire that has a flexible distal end and a relatively stiffer proximal end. A positioning system for the cannula is also disclosed.

摘要翻译： 公开了一种用于进行眼内近距离放射治疗的方法及其执行装置。 该装置优选地包括将辐射源前进到与靶组织相邻定位的相关套管或探针中的手持递送装置。 所述手持件在从套管缩回时提供辐射源的屏蔽存储，并且包括用于前进和后退辐射源的滑块机构。 辐射源安装到具有柔性远端和较硬的近端的导线上。 还公开了用于套管的定位系统。

公开(公告)号：US08365721B2

公开(公告)日：2013-02-05

申请号：US12870459

申请日：2010-08-27

申请人： Charles E. Larsen ,  Richard A. Hillstead ,  Roelof Trip ,  Eugene deJuan ,  Mark S. Humayun ,  Eberhard Fritz ,  Rainer Pintaske ,  Sabine Willenkamp ,  Gerd T. Phillipps

发明人： Charles E. Larsen ,  Richard A. Hillstead ,  Roelof Trip ,  Eugene deJuan ,  Mark S. Humayun ,  Eberhard Fritz ,  Rainer Pintaske ,  Sabine Willenkamp ,  Gerd T. Phillipps

IPC分类号： A61N5/00

CPC分类号： A61N5/1017

摘要： A method for performing intraocular brachytherapy and an apparatus for performing the same is disclosed. The apparatus preferably comprises a hand-held delivery device that advances a radiation source into an associated cannula or probe that is positioned adjacent the target tissue. The handpiece provides for shielded storage of the radiation source when retracted from the cannula and includes a slider mechanism for advancing and retracting the radiation source. The radiation source is mounted to a wire that has a flexible distal end and a relatively stiffer proximal end. A positioning system for the cannula is also disclosed.

摘要翻译： 公开了一种用于进行眼内近距离放射治疗的方法及其执行装置。 该装置优选地包括将辐射源前进到与靶组织相邻定位的相关套管或探针中的手持递送装置。 所述手持件在从套管缩回时提供辐射源的屏蔽存储，并且包括用于前进和后退辐射源的滑块机构。 辐射源安装到具有柔性远端和较硬的近端的导线上。 还公开了用于套管的定位系统。