公开(公告)号：US20110263923A1

公开(公告)日：2011-10-27

申请号：US12963410

申请日：2010-12-08

申请人： Gary A. Lamoureux ,  Warren Johnston ,  Lino Costantini

发明人： Gary A. Lamoureux ,  Warren Johnston ,  Lino Costantini

IPC分类号： A61M36/04

CPC分类号： A61N5/1007 ,  A61N5/10 ,  A61N5/1027 ,  A61N2005/1023 ,  A61N2005/1024

摘要： Spacers for use in brachytherapy, radiotherapy, and other medical therapy, which can be used to improve a patient's outcome, assist in treating difficult cases and/or combine multiple modalities that are currently performed separately into a single procedure. In accordance with an embodiment, a spacer is formed of an encapsulating material in a generally cylindrical or elongated shape. One or more regions are formed within the spacer for receiving and retaining therapeutic loads, such as radiation sources and/or pharmaceutical therapeutic loads, and/or any other substances that a physician might select to treat a patient, such as drug liquids, powder or particles (e.g., microparticles or nanoparticles), with the particles or powders combined with binders, such as polyacrylamide, that are selected to retain and gradually disperse the powder or particles at a desired rate. Such regions can be formed at various locations within the spacer, and can have various shapes depending on the particular design and intended usage, including, for example, bores, end cavities, wells, ports, slots and/or pockets. The outer surface of the encapsulating material can optionally include one or more fins, ribs or other physical protuberances or features that improve the fixity of the spacer when implanted within a patient's body. When implanted into the body, the spacer helps provide proper placement and spacing such as symmetrical and/or asymmetrical placement and spacing of the radiation sources and/or pharmaceutical therapeutic loads.

摘要翻译： 用于近距离放射治疗，放射治疗和其他医学治疗的间隔器，其可用于改善患者的结果，有助于治疗困难情况和/或组合目前单独进行单个手术的多种模式。 根据实施例，间隔件由大致圆柱形或细长形状的封装材料形成。 一个或多个区域形成在间隔件内，用于接纳和保持诸如辐射源和/或药物治疗载荷之类的治疗负荷，和/或医师可能选择用于治疗患者的任何其它物质，例如药物液体，粉末或 颗粒（例如微粒或纳米颗粒），其中颗粒或粉末与粘合剂如聚丙烯酰胺结合，其被选择以保持并以期望的速率逐渐分散粉末或颗粒。 这样的区域可以形成在间隔件内的各个位置处，并且可以根据具体的设计和预期用途具有各种形状，包括例如孔，端腔，孔，端口，槽和/或袋。 封装材料的外表面可以可选地包括一个或多个翅片，肋或其它物理突起或特征，其在植入患者体内时改善间隔物的固定性。 当植入到体内时，间隔件有助于提供适当的放置和间隔，例如辐射源和/或药物治疗负载的对称和/或不对称放置和间隔。

公开(公告)号：US20100305390A1

公开(公告)日：2010-12-02

申请号：US12819969

申请日：2010-06-21

申请人： Jason Reynolds ,  Tony D. Alexander ,  Ji Hwan You

发明人： Jason Reynolds ,  Tony D. Alexander ,  Ji Hwan You

IPC分类号： A61B17/03 ,  A61M36/04

CPC分类号： A61B17/0057 ,  A61B17/00491 ,  A61B17/3468 ,  A61B2017/00004 ,  A61B2017/00654 ,  A61B2017/00867

摘要： The present invention, in an exemplary embodiment, provides a therapeutic medical appliance, delivery device and method of use. In particular, plug therapeutic medical appliances are provided that allow for the interventional treatment of pulmonary disorders such as defects characterized by pulmonary blebs and/or diffused destructive parenchymal disease. The plug therapeutic medical appliances themselves combine many of the excellent characteristics of both silicone and metal therapeutic medical appliances while eliminating the undesirable ones. In particular, these therapeutic medical appliances are preferably self-expanding in nature and allow the predetermined differential selection of relative hardness/softness of regions of the therapeutic medical appliance to provide additional patient comfort. An exemplary embodiment also provides a family of delivery devices that facilitate flexibility, durability and/or proper installation of one or more medical appliances in a single procedure. Moreover, the preferred embodiment of the delivery device provides for the reloading of the delivery device with additional medical appliances for additional interventional procedures.

摘要翻译： 本发明在一个示例性实施例中提供了治疗性医疗器具，输送装置和使用方法。 特别地，提供栓塞治疗医疗器具，其允许介入治疗肺部疾病，例如以肺泡和/或扩散的破坏性实质疾病为特征的缺陷。 插头治疗医疗器具本身结合了硅胶和金属治疗医疗器具的许多优异特性，同时消除不期望的医疗器械。 特别地，这些治疗性医疗器具本质上优选是自膨胀的，并且允许治疗医疗器具区域的相对硬度/柔软度的预定差别选择以提供额外的患者舒适度。 一个示例性实施例还提供了一系列递送装置，其在单个过程中促进一个或多个医疗器具的灵活性，耐久性和/或适当安装。 此外，递送装置的优选实施例提供了用于附加介入程序的附加医疗器具的递送装置的重新加载。

公开(公告)号：US20100191034A1

公开(公告)日：2010-07-29

申请号：US12544101

申请日：2009-08-19

申请人： L. Michael Cutrer ,  Richard A. Terwilliger ,  Joe Wong ,  Fredrick Winch

发明人： L. Michael Cutrer ,  Richard A. Terwilliger ,  Joe Wong ,  Fredrick Winch

IPC分类号： A61M36/04

CPC分类号： A61N5/1015 ,  A61N2005/1018

摘要： A brachytherapy device may include an expandable outer cage, an expandable inner cage positioned within the outer cage and configured to receive radioactive material at its perimeter, and a movable actuator configured to cause the outer and inner cages to expand simultaneously in response to movement of the actuator between certain positions while maintaining a substantially constant separation distance between the outer and inner cages.

摘要翻译： 近距离放射治疗装置可以包括可扩张的外笼，位于外笼内并被配置为在其外周处接收放射性物质的可扩展的内笼，以及可移动的致动器，该致动器构造成使得外壳和内笼同时响应于 致动器在某些位置之间，同时保持外笼和内笼之间的基本恒定的间隔距离。

公开(公告)号：US07736292B2

公开(公告)日：2010-06-15

申请号：US11554731

申请日：2006-10-31

申请人： George D. Hermann ,  Doug S. Sutton ,  Gail S. Lebovic ,  Eduardo Chi Sing ,  Robert R. Bowes

发明人： George D. Hermann ,  Doug S. Sutton ,  Gail S. Lebovic ,  Eduardo Chi Sing ,  Robert R. Bowes

IPC分类号： A61M36/12 ,  A61M36/00 ,  A61M36/04 ,  A61N5/00

CPC分类号： A61N5/1007 ,  A61N5/1014 ,  A61N5/1027 ,  A61N2005/1005 ,  A61N2005/1011 ,  A61N2005/1012 ,  A61N2005/1023 ,  A61N2005/1094

摘要： Apparatus, systems and methods for delivering brachytherapy to a target tissue region of a human or other mammalian body. In some embodiments, a flexible brachytherapy device is implanted that includes a therapy delivery portion having one or more radioactive sources securely retained thereto, and a tail portion extending from the therapy delivery portion. Once implanted, the tail portion may extend outside the body, where it may be folded and secured flat against the skin. The device may be removed at therapy completion. Other embodiments of the invention are directed to systems and methods for delivering brachytherapy devices to the body.

摘要翻译： 用于将近距离放射治疗递送到人或其他哺乳动物身体的靶组织区域的装置，系统和方法。 在一些实施例中，植入柔性近距离放射治疗装置，其包括具有一个或多个可靠地保持在其上的放射源的治疗递送部分和从治疗递送部分延伸的尾部。 一旦植入，尾部可以延伸到身体的外部，在那里它可以被折叠并且平坦地固定在皮肤上。 在治疗完成时可以移除该装置。 本发明的其它实施例涉及用于将近距离放射治疗装置输送到身体的系统和方法。

公开(公告)号：US20080228023A1

公开(公告)日：2008-09-18

申请号：US11980976

申请日：2007-10-31

申请人： Michael L. Jones ,  Frank R. Louw

发明人： Michael L. Jones ,  Frank R. Louw

IPC分类号： A61M36/04 ,  B05D7/22

CPC分类号： A61M25/10 ,  A61M25/003 ,  A61M2025/0036 ,  A61M2025/004

摘要： The disclosure is directed to radiation catheter devices, methods for controlled application of irradiation to tissue at a body site, such as a cavity formed after removal of tissue, e.g. cancer, using such radiation catheter devices, solutions for forming a more lubricious luminal surface and method for lining lumens of such devices to improve the frictional characteristics thereof. The catheter device includes a flexible elongated shaft which is formed of low durometer polymeric material, which can be readily folded or coiled for securing the shaft to or under the skin of the patient and a radiation lumen lined with high durometer polymeric material and finely divided particulate to improve the frictional characteristics. The elongated shaft has at least one inner lumen for receiving a radiation source which has a layer of high durometer polymeric material that provides lower surface friction to facilitate advancement of a radiation source therein.

公开(公告)号：US20080221384A1

公开(公告)日：2008-09-11

申请号：US11757231

申请日：2007-06-01

申请人： Eduardo Chi Sing ,  George D. Hermann ,  Doug S. Sutton ,  Tommy G. Nguyen ,  Mark A. Ritchart ,  Steven L. Gex

发明人： Eduardo Chi Sing ,  George D. Hermann ,  Doug S. Sutton ,  Tommy G. Nguyen ,  Mark A. Ritchart ,  Steven L. Gex

IPC分类号： A61M36/12 ,  A61M36/04

CPC分类号： A61N5/1015 ,  A61N2005/1018

摘要： Apparatus for delivering brachytherapy to a target tissue region includes an elongate body including a proximal end, a distal end sized for introduction into a tissue tract and carrying a plurality of elongate members including pathways for receiving a source of radiation. The elongate members are movable between collapsed and expanded configurations. During use, a tract is created through tissue, and the elongate body carrying the elongate members is advanced through the tract into a target location with the elongate members in the collapsed configuration. The elongate members are directed to the expanded configuration at the target location, and radiation is delivered to treat tissue at the target location, e.g., by introducing one or more radiation sources along the pathways.

摘要翻译： 用于将近距离放射治疗递送到目标组织区域的装置包括细长主体，其包括近端，远端，其尺寸适于引入到组织道中并且承载多个细长构件，包括用于接收辐射源的路径。 细长构件可在折叠和膨胀构型之间移动。 在使用期间，通过组织产生管道，并且携带细长构件的细长体通过管道前进到目标位置，细长构件处于收缩构型。 细长构件在目标位置处被引导到扩展构型，并且例如通过沿着路径引入一个或多个辐射源，传送辐射以在目标位置处理组织。

公开(公告)号：US20080206134A1

公开(公告)日：2008-08-28

申请号：US11710106

申请日：2007-02-22

申请人： Denny Lo ,  Giacomo Basadonna

发明人： Denny Lo ,  Giacomo Basadonna

IPC分类号： A61K51/02 ,  A61K101/00 ,  A61M36/04

CPC分类号： A61M31/005 ,  A61K49/0447 ,  A61L27/025 ,  A61L27/50 ,  A61L29/02 ,  A61L29/18 ,  A61L31/028 ,  A61L31/18 ,  A61L2400/04 ,  A61L2430/36

摘要： A radiographic composition for promoting the formation of clots in blood includes a zeolite and iodine. A device for promoting the clotting of blood at an internal wound site includes a catheter; a delivery instrument insertable through the catheter; a radioopaque blood clotting agent that deliverable through the delivery instrument; and a positive pressure apparatus that can dispense the blood clotting agent to the wound site through the delivery instrument. A system for radiographically imaging an internally bleeding wound includes means for delivering a radioopaque blood clotting agent and means for radiographically imaging the radioopaque blood clotting agent. A method of imaging an internally bleeding wound includes the steps of inserting a catheter into a patient; advancing the catheter to a point adjacent the bleeding wound; depositing a radioopaque zeolite at the bleeding wound; and imaging the radioopaque zeolite to monitor blood-clotting caused by the zeolite.

摘要翻译： 用于促进血液凝块形成的放射摄影组合物包括沸石和碘。 用于促进血液在内部伤口部位凝血的装置包括导管; 可通过导管插入的输送器械; 通过输送仪器输送的不透射线的血液凝固剂; 以及能够通过输送器械将血液凝固剂分配到伤口部位的正压装置。 用于放射线成像内部出血性创伤的系统包括用于递送不透射线的血液凝固剂的装置和用于对放射性斑块血液凝固剂进行射线照相成像的装置。 对内部出血性伤口成像的方法包括将导管插入患者体内的步骤; 将导管推进到与出血伤口相邻的位置; 在出血伤口处沉积不透射线的沸石; 并对放射性不透明沸石进行成像以监测由沸石引起的血液凝固。

公开(公告)号：US20060058568A1

公开(公告)日：2006-03-16

申请号：US10941130

申请日：2004-09-15

申请人： Ian Gross ,  Larry Pierce

发明人： Ian Gross ,  Larry Pierce

IPC分类号： A61M36/04

CPC分类号： A61N5/1027 ,  A61N2005/1008 ,  A61N2005/1025 ,  A61N2005/109 ,  Y10T29/49908 ,  Y10T403/49

摘要： In cancer brachytherapy treatment, a small californium-252 neutron source capsule is attached to a guide cable using a modified crimping technique. The guide cable has a solid cylindrical end, and the attachment employs circumferential grooves micromachined in the solid cable end. The attachment was designed and tested, and hardware fabricated for use inside a radioactive hot cell. A welding step typically required in other cable attachments is avoided.

摘要翻译： 在癌症近距离放射疗法治疗中，使用改进的压接技术将小ium -252中子源囊附接到引导电缆。 引导电缆具有实心的圆柱端，并且附件使用在固体电缆端部微加工的圆周槽。 附件设计和测试，硬件制造用于放射性热电池内部。 避免了其他电缆附件中通常需要的焊接步骤。

公开(公告)号：US06926658B2

公开(公告)日：2005-08-09

申请号：US09775690

申请日：2001-02-01

申请人： Robert C. Farnan

发明人： Robert C. Farnan

IPC分类号： A61M25/00 ,  A61M25/01 ,  A61M36/04 ,  A61N5/01 ,  A61N5/10 ,  A61N5/00

CPC分类号： A61M25/0068 ,  A61M25/0071 ,  A61M25/008 ,  A61M25/0108 ,  A61M2025/0004 ,  A61M2025/0081 ,  A61M2025/0183 ,  A61N5/1002

摘要： Apparatus includes an elongated flexible catheter having proximal and distal end portions, with fluidly connected coaxial lumens extending therebetween, and a diameter sufficiently small for insertion into a patient's intraluminal passageways. One or more treating elements are positionable within one of the lumens and movable between the proximal and distal portions by fluid flowing through the lumens. The distal portion includes a distal guide wire lumen having a proximal exit port distally located relative to the treatment elements positioned at the distal portion. To simultaneously achieve stiffness along the proximal portion and flexibility along the distal portion, the inner and/or outer coaxial members may be of more than one-piece construction. The inner and/or outer members may also be stepped or bumped in diameter to decrease the pressure and fluid transit times within the catheter. A balloon may be added to the distal portion for positioning the catheter or performing angioplasty.

摘要翻译： 装置包括细长的柔性导管，其具有近端部分和远端部分，在其间延伸有流体连接的同轴腔，并且具有足够小的直径以插入患者的管腔内通道中。 一个或多个处理元件可定位在腔内的一个内，并且可以通过流经腔的流体在近端部分和远端部分之间移动。 远侧部分包括远端导丝管腔，远端导丝管腔具有相对于位于远端部分的治疗元件向远侧定位的近端出口端口。 为了同时沿着近端部分实现刚度和沿着远侧部分的柔性，内部和/或外部同轴构件可以是多于一体的构造。 内部和/或外部构件也可以是直径的台阶式或凸起式，以减小导管内的压力和流体传递时间。 可以将球囊添加到远侧部分以用于定位导管或执行血管成形术。

公开(公告)号：US06917828B2

公开(公告)日：2005-07-12

申请号：US09963427

申请日：2001-09-27

申请人： Takashi Fukuda

发明人： Takashi Fukuda

IPC分类号： A61M5/20 ,  A61B5/055 ,  A61B6/00 ,  A61M5/00 ,  A61M5/145 ,  A61M5/19 ,  A61M5/315 ,  A61M36/04

CPC分类号： A61M5/1456 ,  A61M5/007 ,  A61M5/19

摘要： An automatic injection device has piston holders holding cylinder pistons and plural systems of heads having a drive mechanism for moving the piston holders forward and backward so that the device can hold a plurality of syringes and operates injection or suction in each syringe independently. This device also has a mechanism for prohibiting the backward-moving of the piston holder of a second head when the piston holder of a first head is in a forward-moving state and the piston holder of the second head is in a stopped state. This structure effectively prevents liquid from being undesirably mixed and the injection amount thereof from becoming less accurate.

摘要翻译： 自动注射装置具有保持气缸活塞的活塞保持器和具有用于向前和向后移动活塞保持器的驱动机构的多个头部系统，使得该装置可以容纳多个注射器并且独立地在每个注射器中进行注射或抽吸。 当第一头的活塞保持器处于向前移动状态并且第二头部的活塞保持器处于停止状态时，该装置还具有用于禁止第二头部的活塞保持器的向后移动的机构。 该结构有效地防止了液体不期望地混合，并且其注入量变得不太准确。