公开(公告)号：US20060194243A1

公开(公告)日：2006-08-31

申请号：US11381813

申请日：2006-05-05

申请人： Rajeswari Tadakamalla ,  Kai Wu

发明人： Rajeswari Tadakamalla ,  Kai Wu

IPC分类号： C12Q1/68 ,  G06F19/00

CPC分类号： C12Q1/6809 ,  G16B25/00 ,  Y02A90/26 ,  C12Q2565/501 ,  C12Q2531/119 ,  C12Q2521/301

摘要： Methods and computer software products for identifying changes in genomic DNA copy number are disclosed. Methods for identifying homozygous deletions and genetic amplifications are disclosed. Genomic DNA is amplified generically and amplified sample is hybridized to an expression array. The expression array comprises probes to regions of genes that are expressed. The probes are complementary to genomic sequences found in mRNAs. Signal intensity is correlated to copy number. The methods may be used to detect copy number changes in cancerous tissue compared to normal tissue. The methods may be used to diagnose cancer and other diseases associated with chromosomal anomalies.

摘要翻译： 公开了用于鉴定基因组DNA拷贝数变化的方法和计算机软件产品。 公开了鉴定纯合缺失和遗传扩增的方法。 基因组DNA被放大一般，扩增的样品与表达数组杂交。 表达阵列包括对表达的基因区域的探针。 探针与mRNAs中发现的基因组序列互补。 信号强度与拷贝数相关。 与正常组织相比，该方法可用于检测癌组织中的拷贝数变化。 该方法可用于诊断与染色体异常相关的癌症和其他疾病。

公开(公告)号：US20060035258A1

公开(公告)日：2006-02-16

申请号：US11199742

申请日：2005-08-08

申请人： Rajeswari Tadakamalla ,  Kai Wu

发明人： Rajeswari Tadakamalla ,  Kai Wu

IPC分类号： C12Q1/68 ,  G06F19/00 ,  G01N33/48 ,  G01N33/50

CPC分类号： C12Q1/6809 ,  G16B25/00 ,  Y02A90/26 ,  C12Q2565/501 ,  C12Q2531/119 ,  C12Q2521/301

摘要： Methods and computer software products for identifying changes in genomic DNA copy number are disclosed. Methods for identifying homozygous deletions and genetic amplifications are disclosed. Genomic DNA is amplified generically and amplified sample is hybridized to an expression array. The expression array comprises probes to regions of genes that are expressed. The probes are complementary to genomic sequences found in mRNAs. Signal intensity is correlated to copy number. The methods may be used to detect copy number changes in cancerous tissue compared to normal tissue. The methods may be used to diagnose cancer and other diseases associated with chromosomal anomalies.

摘要翻译： 公开了用于鉴定基因组DNA拷贝数变化的方法和计算机软件产品。 公开了鉴定纯合缺失和遗传扩增的方法。 基因组DNA被放大一般，扩增的样品与表达数组杂交。 表达阵列包括对表达的基因区域的探针。 探针与mRNAs中发现的基因组序列互补。 信号强度与拷贝数相关。 与正常组织相比，该方法可用于检测癌组织中的拷贝数变化。 该方法可用于诊断与染色体异常相关的癌症和其他疾病。