公开(公告)号：US06740739B1

公开(公告)日：2004-05-25

申请号：US09582450

申请日：2000-06-26

申请人： Avi J. Ashkenazi ,  Robert F. Kelley ,  Mark P. O'Connell ,  Robert M. Pitti ,  Ralph A. Schwall

发明人： Avi J. Ashkenazi ,  Robert F. Kelley ,  Mark P. O'Connell ,  Robert M. Pitti ,  Ralph A. Schwall

IPC分类号： C07K14525

CPC分类号： C07K14/70575 ,  A61K38/00 ,  C07K2319/00

摘要： A novel cytokine, designated Apo-2 ligand, which induces mammalian cancer cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2 ligand chimeras, nucleic acid encoding Apo-2 ligand, and antibodies to Apo-2 ligand are also provided. Methods of using Apo-2 ligand to induce apoptosis and to treat pathological conditions such as cancer, are further provided.

摘要翻译： 提供了诱导哺乳动物癌细胞凋亡的新型细胞因子，称为Apo-2配体。 Apo-2配体被认为是TNF细胞因子家族的成员。 还提供了包括Apo-2配体嵌合体，编码Apo-2配体的核酸和Apo-2配体的抗体的组合物。 进一步提供了使用Apo-2配体诱导细胞凋亡和治疗病理状况如癌症的方法。