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公开(公告)号：US09321844B2
公开(公告)日：2016-04-26
申请号：US13567919
申请日：2012-08-06
IPC分类号： A61K39/395 , C07K16/40
CPC分类号： C07K16/18 , C07K16/40 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/92 , G01N33/68
摘要： The invention provides anti-polyubiquitin antibodies and methods of using the same.
摘要翻译： 本发明提供抗多聚遍在蛋白抗体及其使用方法。
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公开(公告)号：US09081015B2
公开(公告)日：2015-07-14
申请号：US13361093
申请日：2012-01-30
IPC分类号： A61K39/395 , G01N33/68 , C07K16/18
CPC分类号： C07K16/18 , C07K14/47 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/92 , G01N33/68 , G01N2333/47 , G01N2440/36
摘要： Anti-K63-linked polyubiquitin monoclonal antibodies, and methods for using the antibodies, are provided.
摘要翻译： 提供了抗K63连接的多聚遍在蛋白单克隆抗体，以及使用抗体的方法。
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公开(公告)号：US08105603B2
公开(公告)日：2012-01-31
申请号：US12405018
申请日：2009-03-16
CPC分类号： C07K14/70578 , A61K38/00 , C07K14/70575 , G01N33/564 , G01N2500/02 , Y10S930/12
摘要： The present invention relates to polypeptides that inhibit APRIL and/or BAFF binding to BCMA, nucleic acid molecules encoding the polypeptides, and compositions comprising the polypeptides. The present invention also relates to methods for treating an immune-related disease or cancer using the polypeptides and compositions of the invention. The present invention also relates to methods for identifying inhibitors of APRIL/BAFF binding to BCMA and APRIL/BAFF signaling.
摘要翻译： 本发明涉及抑制与BCMA结合的APRIL和/或BAFF的多肽，编码该多肽的核酸分子以及包含该多肽的组合物。 本发明还涉及使用本发明的多肽和组合物治疗免疫相关疾病或癌症的方法。 本发明还涉及用于鉴定结合BCMA和APRIL / BAFF信号传导的APRIL / BAFF的抑制剂的方法。
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公开(公告)号：US08067002B2
公开(公告)日：2011-11-29
申请号：US11931060
申请日：2007-10-31
申请人： Ling-Ling An , Sek Chung Fung , Robert F. Kelley , Henry B. Lowman , Sanjaya Singh , Herren Wu
发明人： Ling-Ling An , Sek Chung Fung , Robert F. Kelley , Henry B. Lowman , Sanjaya Singh , Herren Wu
IPC分类号： A61K39/395 , C07K16/36
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/40 , C07K2317/24 , C07K2317/50 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
摘要翻译： 本发明涉及人源化抗人因子D单克隆抗体，其核酸和氨基酸序列，携带这些抗体的细胞和载体及其在制备用于治疗与过度或不受控制的疾病和病症的组合物和药物中的用途 补体激活。 这些抗体可用于疾病的诊断，预防和治疗。
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公开(公告)号：US20090297504A1
公开(公告)日：2009-12-03
申请号：US12405018
申请日：2009-03-16
IPC分类号： A61K39/395 , C07K16/00 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/02 , G01N33/53 , A61P35/00 , A61P37/00
CPC分类号： C07K14/70578 , A61K38/00 , C07K14/70575 , G01N33/564 , G01N2500/02 , Y10S930/12
摘要： The present invention relates to polypeptides that inhibit APRIL and/or BAFF binding to BCMA, nucleic acid molecules encoding the polypeptides, and compositions comprising the polypeptides. The present invention also relates to methods for treating an immune-related disease or cancer using the polypeptides and compositions of the invention. The present invention also relates to methods for identifying inhibitors of APRIL/BAFF binding to BCMA and APRIL/BAFF signaling.
摘要翻译： 本发明涉及抑制与BCMA结合的APRIL和/或BAFF的多肽，编码该多肽的核酸分子以及包含该多肽的组合物。 本发明还涉及使用本发明的多肽和组合物治疗免疫相关疾病或癌症的方法。 本发明还涉及用于鉴定结合BCMA和APRIL / BAFF信号传导的APRIL / BAFF的抑制剂的方法。
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公开(公告)号：US06596847B2
公开(公告)日：2003-07-22
申请号：US09355000
申请日：1999-07-14
申请人： Robert F. Kelley , Geoffrey F. Lee
发明人： Robert F. Kelley , Geoffrey F. Lee
IPC分类号： A61K3514
CPC分类号： C07K14/70596 , A61K38/00 , C07K14/745
摘要： The invention provides amino acid sequence variants of tissue factor protein. The tissue factor protein variants have a greater affinity for Factor VII/VIIa than wild-type counterparts. The invention also provides pharmaceutical compositions comprising the novel compositions as well as their use in diagnostic, therapeutic, and prophylactic methods.
摘要翻译： 本发明提供组织因子蛋白质的氨基酸序列变体。 组织因子蛋白质变体对比因子VII / VIIa具有比野生型对应物更大的亲和力。 本发明还提供包含新型组合物的药物组合物及其在诊断，治疗和预防方法中的用途。
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公开(公告)号：US5874407A
公开(公告)日：1999-02-23
申请号：US932589
申请日：1997-09-17
IPC分类号： A61K38/00 , C07K14/745 , C07K14/81 , C12P21/04 , C12P21/06
CPC分类号： C07K14/745 , C07K14/8114 , A61K38/00 , C07K2319/00
摘要： The invention provides compositions having a Factor VIIa active site inhibitor domain and a tissue factor domain for the inhibition of FVIIa. The invention also provides pharmaceutical compositions comprising the novel compositions as well as their use in diagnostic, therapeutic, and prophylactic methods.
摘要翻译： 本发明提供具有因子VIIa活性位点抑制区结构域和用于抑制FVIIa的组织因子结构域的组合物。 本发明还提供包含新型组合物的药物组合物及其在诊断，治疗和预防方法中的用途。
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公开(公告)号：US20120230985A1
公开(公告)日：2012-09-13
申请号：US13461253
申请日：2012-05-01
申请人： LING-LING AN , SEK CHUNG FUNG , ROBERT F. KELLEY , HENRY B. LOWMAN , SANJAYA SINGH , HERREN WU
发明人： LING-LING AN , SEK CHUNG FUNG , ROBERT F. KELLEY , HENRY B. LOWMAN , SANJAYA SINGH , HERREN WU
IPC分类号： A61K39/395 , C12N15/13 , A61P27/02 , C12N5/10 , C12N1/21 , C12N1/19 , C12N1/15 , C07K16/40 , C12N15/63
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/40 , C07K2317/24 , C07K2317/50 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
摘要翻译： 本发明涉及人源化抗人因子D单克隆抗体，其核酸和氨基酸序列，携带这些抗体的细胞和载体及其在制备用于治疗与过度或不受控制的疾病和病症的组合物和药物中的用途 补体激活。 这些抗体可用于疾病的诊断，预防和治疗。
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公开(公告)号：US06740739B1
公开(公告)日：2004-05-25
申请号：US09582450
申请日：2000-06-26
IPC分类号： C07K14525
CPC分类号： C07K14/70575 , A61K38/00 , C07K2319/00
摘要： A novel cytokine, designated Apo-2 ligand, which induces mammalian cancer cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2 ligand chimeras, nucleic acid encoding Apo-2 ligand, and antibodies to Apo-2 ligand are also provided. Methods of using Apo-2 ligand to induce apoptosis and to treat pathological conditions such as cancer, are further provided.
摘要翻译： 提供了诱导哺乳动物癌细胞凋亡的新型细胞因子，称为Apo-2配体。 Apo-2配体被认为是TNF细胞因子家族的成员。 还提供了包括Apo-2配体嵌合体，编码Apo-2配体的核酸和Apo-2配体的抗体的组合物。 进一步提供了使用Apo-2配体诱导细胞凋亡和治疗病理状况如癌症的方法。
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公开(公告)号：US08372403B2
公开(公告)日：2013-02-12
申请号：US13461253
申请日：2012-05-01
申请人： Ling-Ling An , Sek Chung Fung , Robert F. Kelley , Henry B. Lowman , Sanjaya Singh , Herren Wu
发明人： Ling-Ling An , Sek Chung Fung , Robert F. Kelley , Henry B. Lowman , Sanjaya Singh , Herren Wu
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/40 , C07K2317/24 , C07K2317/50 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
摘要翻译： 本发明涉及人源化抗人因子D单克隆抗体，其核酸和氨基酸序列，携带这些抗体的细胞和载体及其在制备用于治疗与过度或不受控制的疾病和病症的组合物和药物中的用途 补体激活。 这些抗体可用于疾病的诊断，预防和治疗。
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