公开(公告)号：US20140148440A1

公开(公告)日：2014-05-29

申请号：US13818152

申请日：2010-11-15

申请人： Ramakrishna Nirogi ,  Anil Karbhari Shinde ,  Ramasastri Kambhampati ,  Rambabu Namala ,  Adi Reddy Dwarampudi ,  Laxman Kota ,  Murlimohan Gampa ,  Padmavathi Kodru ,  Taraka Naga Vinaykumar Tiriveedhi ,  Vishwottam Nagaraj Kandikere ,  Nageshwara Rao Muddana ,  Ramanatha Shrikantha Saralaya ,  Pradeep Jayarajan ,  Dhanalakshmi Shanmuganathan ,  Ishtiyaque Ahmad ,  Venkateswarlu Jasti

发明人： Ramakrishna Nirogi ,  Anil Karbhari Shinde ,  Ramasastri Kambhampati ,  Rambabu Namala ,  Adi Reddy Dwarampudi ,  Laxman Kota ,  Murlimohan Gampa ,  Padmavathi Kodru ,  Taraka Naga Vinaykumar Tiriveedhi ,  Vishwottam Nagaraj Kandikere ,  Nageshwara Rao Muddana ,  Ramanatha Shrikantha Saralaya ,  Pradeep Jayarajan ,  Dhanalakshmi Shanmuganathan ,  Ishtiyaque Ahmad ,  Venkateswarlu Jasti

IPC分类号： C07D513/04 ,  C07D417/12

CPC分类号： C07D513/04 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D498/04

摘要： The present invention relates to heterocyclyl compounds of formula (I), and their pharmaceutically acceptable salts and compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, and their pharmaceutically acceptable salts. The compounds of formula (I) are useful in the treatment of various disorders that are related to Histamine H3 receptors, for example cognitive disorders, sleep disorders, obesity and pain.

摘要翻译： 本发明涉及式（I）的杂环基化合物及其药学上可接受的盐和组合物。 本发明还涉及制备上述新化合物及其药学上可接受的盐的方法。 式（I）化合物可用于治疗与组胺H3受体相关的各种疾病，例如认知障碍，睡眠障碍，肥胖症和疼痛。

公开(公告)号：US09079888B2

公开(公告)日：2015-07-14

申请号：US14000362

申请日：2011-06-07

申请人： Ramakrishna Nirogi ,  Anil Karbhari Shinde ,  Ramasastri Kambhampati ,  Amol Dinakar Deshpande ,  Adi Reddy Dwarampudi ,  Narasimhareddy Gangadasari ,  Sangram Keshari Saraf ,  Vishwottam Nagaraj Kandikere ,  Pradeep Jayarajan ,  Ishtiyaque Ahmad ,  Mohmadsadik Abdulhamid Mulla ,  Venkateswarlu Jasti

发明人： Ramakrishna Nirogi ,  Anil Karbhari Shinde ,  Ramasastri Kambhampati ,  Amol Dinakar Deshpande ,  Adi Reddy Dwarampudi ,  Narasimhareddy Gangadasari ,  Sangram Keshari Saraf ,  Vishwottam Nagaraj Kandikere ,  Pradeep Jayarajan ,  Ishtiyaque Ahmad ,  Mohmadsadik Abdulhamid Mulla ,  Venkateswarlu Jasti

IPC分类号： C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D401/14 ,  C07D211/46

CPC分类号： C07D401/14 ,  C07D211/46 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12

摘要： The present invention relates to novel compounds of formula (I), and their pharmaceutically acceptable salts and compositions containing them. The present invention also relates to a process for the preparation of above compounds of formula (I), and their pharmaceutically acceptable salts.The compounds of formula (I) are useful in the treatment of various disorders that are related to Histamine H3 receptors.

摘要翻译： 本发明涉及式（I）的新化合物及其药学上可接受的盐和组合物。 本发明还涉及制备上述式（I）化合物及其药学上可接受的盐的方法。 式（I）化合物可用于治疗与组胺H3受体相关的各种疾病。

公开(公告)号：US20140135304A1

公开(公告)日：2014-05-15

申请号：US14000362

申请日：2011-06-07

申请人： Ramakrishna Nirogi ,  Anil Karbhari Shinde ,  Ramasastri Kambhampati ,  Amol Dinakar Deshpande ,  Adi Reddy Dwarampudi ,  Narasimhareddy Gangadasari ,  Sangram Keshari Saraf ,  Vishwottam Nagaraj Kandikere ,  Pradeep Jayarajan ,  Ishtiyaque Ahmad ,  Mohmadsadik Abdulhamid Mulla ,  Venkateswarlu Jasti

发明人： Ramakrishna Nirogi ,  Anil Karbhari Shinde ,  Ramasastri Kambhampati ,  Amol Dinakar Deshpande ,  Adi Reddy Dwarampudi ,  Narasimhareddy Gangadasari ,  Sangram Keshari Saraf ,  Vishwottam Nagaraj Kandikere ,  Pradeep Jayarajan ,  Ishtiyaque Ahmad ,  Mohmadsadik Abdulhamid Mulla ,  Venkateswarlu Jasti

IPC分类号： C07D401/14 ,  C07D401/12 ,  C07D211/46

CPC分类号： C07D401/14 ,  C07D211/46 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12

摘要： The present invention relates to novel compounds of formula (I), and their pharmaceutically acceptable salts and compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, and their pharmaceutically acceptable salts.The compounds of formula (I) are useful in the treatment of various disorders that are related to Histamine H3 receptors.

摘要翻译： 本发明涉及式（I）的新化合物及其药学上可接受的盐和组合物。 本发明还涉及制备上述新化合物及其药学上可接受的盐的方法。 式（I）化合物可用于治疗与组胺H3受体相关的各种疾病。

公开(公告)号：US08912179B2

公开(公告)日：2014-12-16

申请号：US13818152

申请日：2010-11-15

申请人： Ramakrishna Nirogi ,  Anil Karbhari Shinde ,  Ramasastri Kambhampati ,  Rambabu Namala ,  Adi Reddy Dwarampudi ,  Laxman Kota ,  Murlimohan Gampa ,  Padmavathi Kodru ,  Taraka Naga Vinaykumar Tiriveedhi ,  Vishwottam Nagaraj Kandikere ,  Nageshwara Rao Muddana ,  Ramanatha Shrikantha Saralaya ,  Pradeep Jayarajan ,  Dhanalakshmi Shanmuganathan ,  Ishtiyaque Ahmad ,  Venkateswarlu Jasti

发明人： Ramakrishna Nirogi ,  Anil Karbhari Shinde ,  Ramasastri Kambhampati ,  Rambabu Namala ,  Adi Reddy Dwarampudi ,  Laxman Kota ,  Murlimohan Gampa ,  Padmavathi Kodru ,  Taraka Naga Vinaykumar Tiriveedhi ,  Vishwottam Nagaraj Kandikere ,  Nageshwara Rao Muddana ,  Ramanatha Shrikantha Saralaya ,  Pradeep Jayarajan ,  Dhanalakshmi Shanmuganathan ,  Ishtiyaque Ahmad ,  Venkateswarlu Jasti

IPC分类号： A61K31/535 ,  A61K31/55 ,  C07D513/04 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D498/04

CPC分类号： C07D513/04 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D498/04

摘要： The present invention relates to heterocyclyl compounds of formula (I), and their pharmaceutically acceptable salts and compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, and their pharmaceutically acceptable salts. The compounds of formula (I) are useful in the treatment of various disorders that are related to Histamine H3 receptors, for example cognitive disorders, sleep disorders, obesity and pain.

摘要翻译： 本发明涉及式（I）的杂环基化合物及其药学上可接受的盐和组合物。 本发明还涉及制备上述新化合物及其药学上可接受的盐的方法。 式（I）化合物可用于治疗与组胺H3受体相关的各种疾病，例如认知障碍，睡眠障碍，肥胖症和疼痛。