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公开(公告)号：US07078430B2
公开(公告)日：2006-07-18
申请号：US10429609
申请日：2003-05-05
Applicant: Yatendra Kumar , Ram Chander Aryan , Jitendra Sattigeri , Mohammad Salman , Gowri Shankar , Kumar Hari Bhushan , Bhargav R. Panyda , Ramnik Sharma
Inventor： Yatendra Kumar , Ram Chander Aryan , Jitendra Sattigeri , Mohammad Salman , Gowri Shankar , Kumar Hari Bhushan , Bhargav R. Panyda , Ramnik Sharma
IPC: A61K31/40 , C07D405/00
CPC classification number: C07D207/34
Abstract: The invention relates to particular hydroxyl and protected hydroxyl derivatives of compounds known to be useful as HMG CoA-reductase inhibitors. In particular, herein are provided hydroxyl and protected hydroxyl compounds of Formula I and their corresponding lactones.
Abstract translation: 本发明涉及已知可用作HMG CoA还原酶抑制剂的化合物的特定羟基和被保护的羟基衍生物。 特别地，本文提供式I的羟基和保护的羟基化合物及其相应的内酯。
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公开(公告)号：US09145421B2
公开(公告)日：2015-09-29
申请号：US14233284
申请日：2012-07-17
Applicant: Ram Chander Aryan , Anamika Mishra , Pudi Giri Jagannadha Naidu , Ramnik Sharma
Inventor： Ram Chander Aryan , Anamika Mishra , Pudi Giri Jagannadha Naidu , Ramnik Sharma
IPC: C07D491/044
CPC classification number: C07D491/044
Abstract: The present invention provides a process for the preparation of asenapine maleate of Formula (I), comprising: intra-molecular cyclization of the intermediate of Formula (II) to obtain the intermediate of Formula (III) using aluminium halide.
Abstract translation: 本发明提供制备式（I）的马来酸asenapine的方法，其包括：式（II）的中间体的分子内环化，以使用卤化铝获得式（III）的中间体。
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公开(公告)号：US20150112083A1
公开(公告)日：2015-04-23
申请号：US14233284
申请日：2012-07-17
Applicant: Ram Chander Aryan , Anamika Mishra , Pudi Giri Jagannadha Naidu , Ramnik Sharma
Inventor： Ram Chander Aryan , Anamika Mishra , Pudi Giri Jagannadha Naidu , Ramnik Sharma
IPC: C07D491/044
CPC classification number: C07D491/044
Abstract: The present invention provides a process for the preparation of asenapine maleate of Formula (I), comprising: intra-molecular cyclization of the intermediate of Formula (II) to obtain the intermediate of Formula (III) using aluminium halide.
Abstract translation: 本发明提供制备式（I）的马来酸asenapine的方法，其包括：式（II）的中间体的分子内环化，以使用卤化铝获得式（III）的中间体。
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公开(公告)号：US20060211761A1
公开(公告)日：2006-09-21
申请号：US10520726
申请日：2003-07-08
Applicant: Yatendra Kumar , Ram Aryan , Jitendra Sattigeri , Mohammad Salman , Gowri Shankar , Kumar Bhushan , Bhargav Pandya , Ramnik Sharma
Inventor： Yatendra Kumar , Ram Aryan , Jitendra Sattigeri , Mohammad Salman , Gowri Shankar , Kumar Bhushan , Bhargav Pandya , Ramnik Sharma
IPC: A61K31/4025 , A61K31/401 , C07D405/02
CPC classification number: C07D207/34
Abstract: The invention relates to particular hydroxyl and protected hydroxyl derivatives of compounds known to be useful as HMG CoA-reductase inhibitors. In particular, herein are provided hydroxyl and protected hydroxyl compounds of Formula I and their corresponding lactones.
Abstract translation: 本发明涉及已知可用作HMG CoA还原酶抑制剂的化合物的特定羟基和被保护的羟基衍生物。 特别地，本文提供式I的羟基和保护的羟基化合物及其相应的内酯。
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