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    Substituted pyrrole derivatives as hmg-coa reductase inhibitors
    5.
    发明申请
    Substituted pyrrole derivatives as hmg-coa reductase inhibitors 审中-公开
    取代的吡咯衍生物作为hmg-coa还原酶抑制剂

    公开(公告)号：US20070149605A1

    公开(公告)日：2007-06-28

    申请号：US10558858

    申请日：2004-05-28

    申请人： Jitendra Sattigeri ,  Mohammad Salman ,  Yatendra Kumar

    发明人： Jitendra Sattigeri ,  Mohammad Salman ,  Yatendra Kumar

    IPC分类号： A61K31/4025 ,  A61K31/401 ,  C07D405/02

    CPC分类号： C07D401/04 ,  C07D403/12 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D417/12 ,  C07D417/14

    摘要： The present invention relates to substituted pyrrole derivatives of Formula (I), wherein (Y), with the proviso that one of R2, R4 and R5 is a heterocycle and with the further provision that if R2 is not a heterocycle then either R4 or R5 alone is not unsubstituted pyridyl, which can be used as 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors. Compounds disclosed herein can function as cholesterol lowering agents and can be used for the treatment of cholesterol-related diseases and related symptoms. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and methods of treating cholesterol-related diseases and related symptoms.

    摘要翻译： 本发明涉及式（I）的取代吡咯衍生物，其中（Y），条件是R 2，R 4和R 5中的一个 并且进一步的规定是，如果R 2不是杂环，则R 4或R 5独立地是 未被取代的吡啶基，可用作3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶抑制剂。 本文公开的化合物可用作胆固醇降低剂，并且可用于治疗胆固醇相关疾病和相关症状。 提供了制备所公开化合物的方法，以及含有所公开化合物的药物组合物，以及治疗胆固醇相关疾病和相关症状的方法。

    Monosaccharide Derivatives as Anti-Inflammatory and/or Anti-Cancer Agents
    7.
    发明申请
    Monosaccharide Derivatives as Anti-Inflammatory and/or Anti-Cancer Agents 审中-公开
    单糖衍生物作为抗炎和/或抗癌剂

    公开(公告)号：US20090048186A1

    公开(公告)日：2009-02-19

    申请号：US11912064

    申请日：2005-04-19

    申请人： Vishwajanani Jitendra Sattigeri ,  Sudershan K. Arora ,  Mohammad Salman ,  Venkata P. Palle ,  Ashis Mukherjee ,  Abhijit Ray ,  Raj Kumar Shirumalla

    发明人： Vishwajanani Jitendra Sattigeri ,  Sudershan K. Arora ,  Mohammad Salman ,  Venkata P. Palle ,  Ashis Mukherjee ,  Abhijit Ray ,  Raj Kumar Shirumalla

    IPC分类号： A61K31/7052 ,  C07H15/18 ,  A61K31/7034 ,  C07D493/04 ,  C07H17/02

    CPC分类号： C07H9/04 ,  C07H3/02 ,  C07H15/00

    摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disorder herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis and allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.

    摘要翻译： 本发明涉及作为抗炎剂的单糖衍生物。 本文中的化合物障碍可用于抑制和预防炎症和相关病理，包括炎症和自身免疫性疾病，例如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮， 动脉粥样硬化，癌症，瘙痒和过敏性鼻炎。 含有本文公开的化合物的药理学组合物和治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒，过敏性 还提供使用该化合物的鼻炎和其它炎性和/或自身免疫性疾病。

    MONOSACCHARIDE DERIVATIVES
    8.
    发明申请
    MONOSACCHARIDE DERIVATIVES 审中-公开
    单糖衍生物

    公开(公告)号：US20090221515A1

    公开(公告)日：2009-09-03

    申请号：US11574465

    申请日：2005-08-31

    申请人： Viswajanani Jitendra Sattigeri ,  Sudershan K. Arora ,  Venkata P. Palle ,  Mohammad Salman ,  Abhijit Ray ,  Raj Kumar Shirumalla ,  Abdul Rehaman Abdul Rauf

    发明人： Viswajanani Jitendra Sattigeri ,  Sudershan K. Arora ,  Venkata P. Palle ,  Mohammad Salman ,  Abhijit Ray ,  Raj Kumar Shirumalla ,  Abdul Rehaman Abdul Rauf

    IPC分类号： A61K31/7008 ,  C07H5/04

    CPC分类号： C07H15/18

    摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies, including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis or allergic rhinitis. Pharmacological compositions containing the compounds of the present invention and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.

    摘要翻译： 本发明涉及作为抗炎剂的单糖衍生物。 本文公开的化合物可用于抑制和预防炎症和相关病理学，包括炎症和自身免疫性疾病如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮 ，动脉粥样硬化，癌症，瘙痒症或过敏性鼻炎。 包含本发明化合物的药物组合物，治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症， 还提供了使用该化合物的瘙痒症，过敏性鼻炎和其它炎性和/或自身免疫性疾病。