公开(公告)号：US20050215814A1

公开(公告)日：2005-09-29

申请号：US10813696

申请日：2004-03-29

申请人： Raghunath Chaudhari ,  Rashmi Chansarkar ,  Kausik Mukhopadhyay ,  Ashutosh Kelkar

发明人： Raghunath Chaudhari ,  Rashmi Chansarkar ,  Kausik Mukhopadhyay ,  Ashutosh Kelkar

IPC分类号： C07C67/29 ,  C07C67/297 ,  C07C67/36

CPC分类号： C07C67/29 ,  C07C67/293 ,  C07C67/297 ,  C07C69/007 ,  C07C69/145 ,  C07C69/16

摘要： The present invention relates to a process for the preparation of esters of hydroxy tiglic aldehydes which are the key intermediates for Vitamin-A acetate synthesis and various perfumistic products, said process relates to the hydroformylation of biscarboxylic esters of but-2-ene-1,4-diol, followed by deacetoxylation of its hydroformylation compound, in the presence of heterogeneous catalyst having rhodium complex entrapped, anchored or teethered on the acidic support, said acidic support causes deacetoxylation in the reaction mixture immediately after hydroformylation, to give 100% selectivity to the carboxylic esters of hydroxyl tiglic aldehydes in a single step.

摘要翻译： 本发明涉及一种用于制备维生素A乙酸酯合成的关键中间体的羟基叔丁醛的酯的方法和各种香料产物，所述方法涉及丁-2-烯-1的双羧酸酯的加氢甲酰化， 然后在其加氢甲酰化化合物脱甲酰化，在含有铑络合物的非均相催化剂的存在下，在酸性载体上被捕获，锚定或引导，所述酸性载体在加氢甲酰化后立即在反应混合物中引起脱乙酰氧基化，得到100％选择性 在单一步骤中羟基叔丁醛的羧酸酯。

公开(公告)号：US07288672B2

公开(公告)日：2007-10-30

申请号：US10813696

申请日：2004-03-29

申请人： Raghunath Vitthal Chaudhari ,  Rashmi Chansarkar ,  Kausik Mukhopadhyay ,  Ashutosh Anant Kelkar

发明人： Raghunath Vitthal Chaudhari ,  Rashmi Chansarkar ,  Kausik Mukhopadhyay ,  Ashutosh Anant Kelkar

IPC分类号： C07C67/36

CPC分类号： C07C67/29 ,  C07C67/293 ,  C07C67/297 ,  C07C69/007 ,  C07C69/145 ,  C07C69/16

摘要： The present invention relates to a process for the preparation of esters of hydroxy tiglic aldehydes which are the key intermediates for Vitamin-A acetate synthesis and various perfumistic products, said process relates to the hydroformylation of biscarboxylic esters of but-2-ene-1,4-diol, followed by deacetoxylation of its hydroformylation compound, in the presence of heterogeneous catalyst having rhodium complex entrapped, anchored or teethered on the acidic support, said acidic support causes deacetoxylation in the reaction mixture immediately after hydroformylation, to give 100% selectivity to the carboxylic esters of hydroxyl tiglic aldehydes in a single step.

摘要翻译： 本发明涉及一种用于制备维生素A乙酸酯合成的关键中间体的羟基叔丁醛的酯的方法和各种香料产物，所述方法涉及丁-2-烯-1的双羧酸酯的加氢甲酰化， 然后在其加氢甲酰化化合物脱甲酰化，在含有铑络合物的非均相催化剂的存在下，在酸性载体上被捕获，锚定或引导，所述酸性载体在加氢甲酰化后立即在反应混合物中引起脱乙酰氧基化，得到100％选择性 在单一步骤中羟基叔丁醛的羧酸酯。