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    Process for the production of 4-alkanoyloxy-2-methylbutanoic acid
    3.
    发明授权
    Process for the production of 4-alkanoyloxy-2-methylbutanoic acid 有权
    生产4-烷酰氧基-2-甲基丁酸的方法

    公开(公告)号：US09447017B2

    公开(公告)日：2016-09-20

    申请号：US14401868

    申请日：2013-06-05

    Applicant: DSM IP ASSETS B.V.

    Inventor： Werner Bonrath ,  Jan Schütz ,  Bettina Wüstenberg ,  Thomas Netscher

    IPC: C07D311/00 ,  C07C69/66 ,  C07C67/29 ,  C07C29/15 ,  C07C45/00 ,  C07D311/72

    CPC classification number: C07C67/29 ,  C07C29/15 ,  C07C45/008 ,  C07D311/72 ,  C07C69/14

    Abstract: The present invention relates to an improved process for the production of 4-alkanoyloxy-2-methylbutanoic acid, as well as to the use of such compounds in organic syntheses, especially in processes forming intermediates (building blocks) for the synthesis of organic compounds comprising isoprene (isoterpene) units, such as β-carotene or other carotenoids (e.g. canthaxanthin, zeaxanthin or astaxanthin) or as vitamin E or vitamin A as well as other structurally similar compounds.

    Abstract translation: 本发明涉及一种生产4-烷酰氧基-2-甲基丁酸的改进方法，以及这些化合物在有机合成中的用途，特别是在形成用于合成有机化合物的中间体（构成单元）的方法中的用途，所述方法包括 异戊二烯（异萜烯）单元，例如β-胡萝卜素或其他类胡萝卜素（例如角黄素，玉米黄质或虾青素）或维生素E或维生素A以及其它结构相似的化合物。

    Catalytic synthesis of vitamin A intermediate
    6.
    发明授权
    Catalytic synthesis of vitamin A intermediate 有权
    维生素A中间体的催化合成

    公开(公告)号：US09040742B2

    公开(公告)日：2015-05-26

    申请号：US14368914

    申请日：2012-12-14

    Applicant: DSM IP ASSETS B.V.

    Inventor： Werner Bonrath ,  Bettina Wuestenberg ,  Thomas Netscher ,  Jan Schuetz

    IPC: C07C67/29 ,  C07C69/00

    CPC classification number: C07C67/29 ,  C07C403/12 ,  C07C2601/16

    Abstract: The present invention relates to a process of production of a compound, which is useful as an intermediate (building block) in organic synthesis, especially in the synthesis of vitamin A or β-carotene and derivatives thereof, e.g. canthaxanthin, astaxanthin or zeaxanthin.

    Abstract translation: 本发明涉及一种化合物的制备方法，其可用作有机合成中的中间体（结构单元），特别是合成维生素A或其组合物 - 胡萝卜素及其衍生物。 角黄素，虾青素或玉米黄质。

    Sirtuin activating compounds and processes for making the same
    7.
    发明授权
    Sirtuin activating compounds and processes for making the same 有权
    Sirtuin活化化合物及其制备方法

    公开(公告)号：US08841477B2

    公开(公告)日：2014-09-23

    申请号：US12503239

    申请日：2009-07-15

    Applicant: Merritt B. Andrus ,  Jing Liu

    Inventor： Merritt B. Andrus ,  Jing Liu

    IPC: C07C69/88 ,  C07C67/29 ,  C07C69/017 ,  C07C67/287 ,  C07C67/293 ,  C07C67/08 ,  C07C67/14

    CPC classification number: C07C69/017 ,  C07C67/08 ,  C07C67/14 ,  C07C67/287 ,  C07C67/29 ,  C07C67/293 ,  Y02P20/55 ,  C07C69/716 ,  C07C69/63 ,  C07C69/18 ,  C07C69/16

    Abstract: The present invention includes methods for preparing resveratrol, resveratrol esters and substituted and unsubstituted stilbenes of the formula given below; where each Y is —O or halogen, each Z is —O or halogen, each n and each m is independently the value of 0, 1, 2, 3, 4 or 5, each A and each B is independently selected from Pn, R or absent, each V and each W is independently selected from Pn, straight or branched alkyl of from 2 to 6 carbon atoms and cycloalkyl of from 3 to 8 carbon atoms, alkoxy, phenyl, benzyl or halogen, R is independently selected from the group comprising alkyl with at least one carbon atom, aryl and aralkyl, Pn is an alcohol protecting group and diastereoisomers of the foregoing. The compounds are made from a multi-step process including a N-heterocyclic carbene-type ligand coupling in the presence of a base with benzyol halide and styrene coupling partners. These compounds show increased stability for use in the food, cosmetic and pharmaceutical industries.

    Abstract translation: 本发明包括用于制备下列给出的式的白藜芦醇，白藜芦醇酯和取代和未取代的二苯乙烯的方法; 其中每个Y是-O或卤素，每个Z是-O或卤素，每个n和每个m独立地是0,1,2,3,4或5的值，每个A和每个B独立地选自Pn， R或不存在，每个V和每个W独立地选自Pn，2至6个碳原子的直链或支链烷基和3至8个碳原子的环烷基，烷氧基，苯基，苄基或卤素，R独立地选自 包含至少一个碳原子的烷基，芳基和芳烷基，Pn是上述的醇保护基和非对映异构体。 所述化合物由多步法制备，包括在碱存在下与苄氧基卤化物和苯乙烯偶联配偶体的N-杂环卡宾型配体偶联。 这些化合物在食品，化妆品和制药工业中显示出增加的稳定性。

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