公开(公告)号：US5489612A

公开(公告)日：1996-02-06

申请号：US178610

申请日：1994-01-07

申请人： Jerry L. Atwood ,  Robert J. Bridges ,  Ravindra K. Juneja ,  Ashvani K. Singh

发明人： Jerry L. Atwood ,  Robert J. Bridges ,  Ravindra K. Juneja ,  Ashvani K. Singh

IPC分类号： A61K31/185 ,  A61K31/19 ,  A61K31/10 ,  A61K31/165

CPC分类号： A61K31/185

摘要： Calixarene derivatives, their synthesis and use as chloride channel blockers are described. Preferred calixarene derivatives are of the formula: ##STR1## wherein R is an acidic group or salt thereof, such as SO.sub.3 X or R.sup.1 SO.sub.3 X where X is H or Na, and R.sup.1 is ##STR2## where m=1-2, and R.sup.3 and R.sup.4 the same or different is each H or a C.sub.1-4 alkyl, or a nitrogen-containing group of the formula ##STR3## or A, wherein R.sup.5 is a C.sub.1-4 alkyl, R.sup.6 is a C.sub.1-4 alkyl and A is ##STR4## where R.sup.7 and R.sup.8, the same or different each is H or a C.sub.1-4 alkyl, and R.sup.9 and R.sup.10, the same or different, each is H or a C.sub.1-4 alkyl; R' is H or a C.sub.1-4 alkyl; and n is an integer of 4-8, preferably 4, 6 or 8.

摘要翻译： 描述了杯芳烃衍生物，它们作为氯化物通道阻断剂的合成和用途。 优选的杯芳烃衍生物具有下式：其中R是酸性基团或其盐，例如SO 3 X或R 1 SO 3 X，其中X是H或Na，R 1是其中m = 1-2，R 3和R 4 相同或不同的是每个H或C 1-4烷基或式IMA或A的含氮基团，其中R 5是C 1-4烷基，R 6是C 1-4烷基，A是