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公开(公告)号：US08460699B2
公开(公告)日：2013-06-11
申请号：US13593310
申请日：2012-08-23
CPC分类号： A61F13/534 , A61L15/18 , A61L15/44 , A61L2300/102 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/418 , A61L2400/04
摘要： A device for promoting the clotting of blood comprises a clay material in particle form and a receptacle for containing the clay material. At least a portion of the receptacle is defined by a mesh. Another device comprises a gauze substrate and a clay material disposed on the gauze substrate. Another device is a bandage comprising a substrate, a mesh mounted on the substrate, and particles of a clay material retained in the mesh. A hemostatic sponge comprises a substrate, a hemostatic material disposed on a first surface of the substrate, and a release agent disposed on a second surface of the substrate. The release agent is disposed on the wound-contacting surface of the substrate. When treating a bleeding wound, application of the hemostatic sponge causes at least a portion of the hemostatic material to come into contact with blood through the release agent and through the substrate.
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公开(公告)号：US20090162406A1
公开(公告)日：2009-06-25
申请号：US12204129
申请日：2008-09-04
申请人： Giacomo Basadonna , Raymond J. Huey , Denny Lo
发明人： Giacomo Basadonna , Raymond J. Huey , Denny Lo
CPC分类号： A61K33/06 , A61L15/18 , A61L26/0004 , A61L2400/04
摘要： A method for decreasing the time it takes for a wound to heal includes applying hemostatic agent to the wound, inflaming tissue surrounding the wound to facilitate the deposition of fibroblast, thereby accelerating the subsequent contraction of the wound and the onset of the proliferative healing stage, and causing the re-epithelization of the tissue at a faster rate than if no hemostatic agent was applied. A method for promoting the healing of a bleeding wound includes coating a hemostatic agent onto a substrate, applying the substrate to the bleeding wound so that an effective amount of the hemostatic agent is applied to the wound, inflaming the tissue, and causing the re-epithelization of the tissue at a faster rate than if no hemostatic agent was applied. In at least some methods, a clotting cascade and platelet aggregation within the bleeding wound is accelerated, and blood loss from the wound is decreased.
摘要翻译： 减少伤口愈合所需的时间的方法包括将伤口上的止血剂施加到伤口周围，使周围的组织发炎，促进成纤维细胞的沉积，从而加速伤口随后的收缩和增殖愈合阶段的开始， 并且以比没有使用止血剂更快的速率引起组织的再上皮化。 用于促进出血性伤口愈合的方法包括将止血剂涂覆在基底上，将基底施加到出血伤口，使得有效量的止血剂施加到伤口上，使组织发炎， 组织的上皮化速度比没有使用止血剂的速率更快。 在至少一些方法中，加速了出血性伤口内的凝血级联和血小板聚集，并且伤口的失血减少。
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公开(公告)号：US20080085300A1
公开(公告)日：2008-04-10
申请号：US11544238
申请日：2006-10-06
申请人： Raymond J. Huey , Denny Lo
发明人： Raymond J. Huey , Denny Lo
IPC分类号： A61L15/00
CPC分类号： A61L26/0066 , A61L2300/418 , A61L2300/606 , A61L2400/04
摘要： A composition for promoting hemostasis is defined by a substrate in particle or pellet form and a hemostatic agent disposed on the substrate such that when using the composition to treat a bleeding wound, contacting the bleeding wound with the hemostatic agent causes blood to clot. The hemostatic agent may be a zeolite, bioactive glass, siliceous oxide, clay, biological hemostatic material, diatomaceous earth, or a combination of the foregoing. The substrate may be clay, glass, bioactive glass, diatomaceous earth, wax, polymer, plastic, metal, or a combination of the foregoing. A method of fabricating a hemostatic composition includes providing a substrate and a material having hemostatic characteristics. The hemostatic composition is fabricated by providing a material to operate as a carrier for the hemostatic material. The material is formed into particles or pellets. The material having hemostatic properties is applied or coated onto the particles of the carrier material.
摘要翻译： 用于促进止血的组合物由颗粒或颗粒形式的底物和设置在基质上的止血剂限定，使得当使用该组合物治疗出血性创伤时，使止血剂与止血剂接触使血液凝结。 止血剂可以是沸石，生物活性玻璃，氧化硅，粘土，生物止血材料，硅藻土，或前述的组合。 基底可以是粘土，玻璃，生物活性玻璃，硅藻土，蜡，聚合物，塑料，金属或前述的组合。 制备止血组合物的方法包括提供具有止血特性的基底和材料。 止血组合物通过提供用作止血材料的载体的材料来制造。 该材料形成颗粒或颗粒。 具有止血性的材料被施加或涂覆在载体材料的颗粒上。
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公开(公告)号：US08383148B2
公开(公告)日：2013-02-26
申请号：US13526431
申请日：2012-06-18
CPC分类号： A61L15/18 , A61F13/00063 , A61F2013/00472 , A61F2013/00548 , A61F2013/00744 , A61L15/44 , A61L2300/418 , A61L2300/802 , A61L2400/04
摘要： A device for promoting the clotting of blood comprises a clay material in particle form and a receptacle for containing the clay material. At least a portion of the receptacle is defined by a mesh. Another device comprises a gauze substrate and a clay material disposed on the gauze substrate. Another device is a bandage comprising a substrate, a mesh mounted on the substrate, and particles of a clay material retained in the mesh. A hemostatic sponge comprises a substrate, a hemostatic material disposed on a first surface of the substrate, and a release agent disposed on a second surface of the substrate. The release agent is disposed on the wound-contacting surface of the substrate. When treating a bleeding wound, application of the hemostatic sponge causes at least a portion of the hemostatic material to come into contact with blood through the release agent and through the substrate.
摘要翻译： 用于促进血液凝结的装置包括颗粒形式的粘土材料和用于容纳粘土材料的容器。 容器的至少一部分由网格限定。 另一种装置包括纱布基底和布置在纱布基底上的粘土材料。 另一种装置是包括基底，安装在基底上的网和保留在网中的粘土材料颗粒的绷带。 止血海绵包括基材，设置在基材的第一表面上的止血材料和设置在基材的第二表面上的脱模剂。 脱模剂设置在基材的卷绕接触表面上。 当治疗出血的伤口时，止血海绵的施用使至少一部分止血材料通过脱模剂和通过基底与血液接触。
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公开(公告)号：US08257732B2
公开(公告)日：2012-09-04
申请号：US13115699
申请日：2011-05-25
CPC分类号： A61F13/534 , A61L15/18 , A61L15/44 , A61L2300/102 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/418 , A61L2400/04
摘要： A device for promoting the clotting of blood comprises a clay material in particle form and a receptacle for containing the clay material. At least a portion of the receptacle is defined by a mesh. Another device comprises a gauze substrate and a clay material disposed on the gauze substrate. Another device is a bandage comprising a substrate, a mesh mounted on the substrate, and particles of a clay material retained in the mesh. A hemostatic sponge comprises a substrate, a hemostatic material disposed on a first surface of the substrate, and a release agent disposed on a second surface of the substrate. The release agent is disposed on the wound-contacting surface of the substrate. When treating a bleeding wound, application of the hemostatic sponge causes at least a portion of the hemostatic material to come into contact with blood through the release agent and through the substrate.
摘要翻译： 用于促进血液凝结的装置包括颗粒形式的粘土材料和用于容纳粘土材料的容器。 容器的至少一部分由网格限定。 另一种装置包括纱布基底和布置在纱布基底上的粘土材料。 另一种装置是包括基底，安装在基底上的网和保留在网中的粘土材料颗粒的绷带。 止血海绵包括基材，设置在基材的第一表面上的止血材料和设置在基材的第二表面上的脱模剂。 脱模剂设置在基材的卷绕接触表面上。 当治疗出血的伤口时，止血海绵的施用使至少一部分止血材料通过脱模剂和通过基底与血液接触。
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6.发明申请DEVICES AND METHODS FOR THE DELIVERY OF BLOOD CLOTTING MATERIALS TO BLEEDING WOUNDS 有权用于输送血液粘贴材料以发芽的装置和方法公开(公告)号：US20130041332A1
公开(公告)日：2013-02-14
申请号：US13595932
申请日：2012-08-27
申请人： Raymond J. Huey , Jeffrey L. Horn
发明人： Raymond J. Huey , Jeffrey L. Horn
IPC分类号： A61M35/00
摘要： An apparatus for promoting the clotting of blood and controlling bleeding comprises a receptacle for retaining blood clotting material in particulate form therein. A pad for controlling bleeding comprises a mesh structure and a support attached to the mesh structure to facilitate the application of pressure to the pad and the wound. A bandage applicable to a bleeding wound comprises a mesh structure and a flexible substrate attached to the mesh structure, the substrate being a cloth or plastic member that may be adhesively attachable to cover a wound. In any embodiment, at least a portion of the receptacle or mesh structure is defined by a mesh having openings therein, and at least a portion of the particulate blood clotting material is in direct contact with blood. The mesh may include a zeolite powder impregnated or otherwise incorporated therein.
摘要翻译： 用于促进血液凝固和控制出血的装置包括用于将血液凝固材料保持在其中的颗粒形式的容器。 用于控制出血的垫包括网状结构和附接到网状结构的支撑体，以便于对垫和伤口施加压力。 适用于流血创伤的绷带包括网状结构和附着到网状结构的柔性基底，该基底是可粘合地附着以覆盖伤口的布或塑料构件。 在任何实施例中，容器或网状结构的至少一部分由其中具有开口的网格限定，并且至少一部分颗粒状血液凝结材料与血液直接接触。 网可以包括浸渍或以其他方式并入其中的沸石粉末。
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公开(公告)号：US20120259262A1
公开(公告)日：2012-10-11
申请号：US13526431
申请日：2012-06-18
CPC分类号： A61L15/18 , A61F13/00063 , A61F2013/00472 , A61F2013/00548 , A61F2013/00744 , A61L15/44 , A61L2300/418 , A61L2300/802 , A61L2400/04
摘要： A device for promoting the clotting of blood comprises a clay material in particle form and a receptacle for containing the clay material. At least a portion of the receptacle is defined by a mesh. Another device comprises a gauze substrate and a clay material disposed on the gauze substrate. Another device is a bandage comprising a substrate, a mesh mounted on the substrate, and particles of a clay material retained in the mesh. A hemostatic sponge comprises a substrate, a hemostatic material disposed on a first surface of the substrate, and a release agent disposed on a second surface of the substrate. The release agent is disposed on the wound-contacting surface of the substrate. When treating a bleeding wound, application of the hemostatic sponge causes at least a portion of the hemostatic material to come into contact with blood through the release agent and through the substrate.
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公开(公告)号：US20120130296A1
公开(公告)日：2012-05-24
申请号：US13363270
申请日：2012-01-31
CPC分类号： A61L15/44 , A61F13/00012 , A61F13/00063 , A61L15/18 , A61L15/28 , A61L15/425 , A61L2300/404 , A61L2300/406 , A61L2400/04 , A61L2400/16
摘要： A hemostatic device for promoting the dotting of blood includes a gauze substrate, a clay material disposed on the gauze substrate, and also a polyol such as glycerol or the like disposed on the gauze substrate to bind the clay material. When the device is used to treat a bleeding wound, at least a portion of the clay material comes into contact with blood emanating from the wound to cause the clotting. A bandage that can be applied to a bleeding wound to promote the clotting of blood includes a flexible substrate and a gauze substrate mounted thereon. The gauze substrate includes a clay material and a polyol. A hemostatic sponge also includes a gauze substrate and a dispersion of hemostatic material and a polyol on a first surface of the substrate.
摘要翻译： 用于促进血液点滴的止血装置包括纱布基材，布置在纱布基材上的粘土材料，以及布置在纱布基材上以粘合粘土材料的多元醇如甘油等。 当该装置用于治疗流血的伤口时，至少一部分粘土材料与从伤口发出的血液接触以引起凝血。 可以应用于流血伤口以促进血液凝结的绷带包括安装在其上的柔性基底和纱布基底。 纱布基材包括粘土材料和多元醇。 止血海绵还包括纱布基底和止血材料和多元醇在基底的第一表面上的分散体。
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公开(公告)号：US08114433B2
公开(公告)日：2012-02-14
申请号：US12581782
申请日：2009-10-19
CPC分类号： A61L15/44 , A61F13/00012 , A61F13/00063 , A61L15/18 , A61L15/28 , A61L15/425 , A61L2300/404 , A61L2300/406 , A61L2400/04 , A61L2400/16
摘要： A hemostatic device for promoting the clotting of blood includes a gauze substrate, a clay material disposed on the gauze substrate, and also a polyol such as glycerol or the like disposed on the gauze substrate to bind the clay material. When the device is used to treat a bleeding wound, at least a portion of the clay material comes into contact with blood emanating from the wound to cause the clotting. A bandage that can be applied to a bleeding wound to promote the clotting of blood includes a flexible substrate and a gauze substrate mounted thereon. The gauze substrate includes a clay material and a polyol. A hemostatic sponge also includes a gauze substrate and a dispersion of hemostatic material and a polyol on a first surface of the substrate.
摘要翻译： 用于促进血液凝结的止血装置包括纱布基底，布置在纱布基底上的粘土材料，以及布置在纱布基底上以粘合粘土材料的多元醇，例如甘油等。 当该装置用于治疗流血的伤口时，至少一部分粘土材料与从伤口发出的血液接触以引起凝血。 可以应用于流血伤口以促进血液凝结的绷带包括安装在其上的柔性基底和纱布基底。 纱布基材包括粘土材料和多元醇。 止血海绵还包括纱布基底和止血材料和多元醇在基底的第一表面上的分散体。
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公开(公告)号：US20100228174A1
公开(公告)日：2010-09-09
申请号：US12611830
申请日：2009-11-03
CPC分类号： A61L15/18 , A61F13/00063 , A61F2013/00472 , A61F2013/00548 , A61F2013/00744 , A61L15/44 , A61L2300/418 , A61L2300/802 , A61L2400/04
摘要： Disclosed are device for promoting the clotting of blood comprising a clay material and a release agent. In some embodiments, the clay material is disposed within a substrate and the release agent is disposed within a mesh. The release agent can be configured to make direct contact with a bleeding wound when the device is in particle form and the clay material can promote hemostasis.
摘要翻译： 公开了用于促进包含粘土材料和脱模剂的血液凝血的装置。 在一些实施例中，粘土材料设置在基材内，脱模剂设置在网内。 脱模剂可以构造成当装置处于颗粒形式时与出血的伤口直接接触，并且粘土材料可以促进止血。
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