公开(公告)号：US07326788B2

公开(公告)日：2008-02-05

申请号：US10894940

申请日：2004-07-20

Applicant: Mark J. Wall ,  Mark R. Player ,  Raymond Joseph Patch ,  Sanath Meegalla ,  Jian Liu ,  Carl R. Illig ,  Wing Cheung ,  Jinsheng Chen ,  Davoud Asgari

Inventor： Mark J. Wall ,  Mark R. Player ,  Raymond Joseph Patch ,  Sanath Meegalla ,  Jian Liu ,  Carl R. Illig ,  Wing Cheung ,  Jinsheng Chen ,  Davoud Asgari

IPC: C07D215/38 ,  C07D215/44

CPC classification number: C07D215/227 ,  C07D401/04 ,  C07D409/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  Y02P20/582

Abstract: The invention is directed to compounds of Formulae I and II: wherein R1, R2, R3, R5, R6, Y1, Y2, Y3, Y4 and X are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase.

Abstract translation: 本发明涉及式I和II的化合物：其中R 1，R 2，R 3，R 5， 其中，R 6，R 6，Y 1，Y 2，Y 3，Y 4， SUP＆amp; X和X在本说明书中列出，以及其抑制蛋白酪氨酸激酶，特别是c-fms激酶的溶剂合物，水合物，互变异构体或其药学上可接受的盐。