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    Inhibitors of c-fms kinase
    3.
    发明授权
    Inhibitors of c-fms kinase 有权
    c-fms激酶抑制剂

    公开(公告)号：US08497376B2

    公开(公告)日：2013-07-30

    申请号：US12252439

    申请日：2008-10-16

    申请人： Carl R. Illig ,  Jinsheng Chen ,  Sanath K. Meegalia ,  Mark J. Wall

    发明人： Carl R. Illig ,  Jinsheng Chen ,  Sanath K. Meegalia ,  Mark J. Wall

    IPC分类号： C07D405/14 ,  C07D471/04 ,  C07D493/08

    CPC分类号： C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D471/08 ,  C07D493/08

    摘要： The invention is directed to compounds of Formula I: wherein Z, X, J, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, prostate cancer, lung cancer, colon cancer, stomach cancer, hairy cell leukemia; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including rheumatoid arthritis, and other forms of inflammatory arthritis, osteoarthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.

    摘要翻译： 本发明涉及式I化合物：其中Z，X，J，R 2和W在本说明书中列出，以及其抑制蛋白酪氨酸激酶，特别是c-型的溶剂化物，水合物，互变异构体和药学上可接受的盐， fms激酶。 治疗自身免疫性疾病的方法 和具有炎症成分的疾病; 治疗卵巢癌，子宫癌，乳腺癌，前列腺癌，肺癌，结肠癌，胃癌，毛细胞白血病的转移; 并治疗疼痛，包括由肿瘤转移或骨关节炎引起的骨骼疼痛，或内脏，炎症和神经源性疼痛; 骨质疏松症，佩吉特氏病和其他疾病，其中骨吸收介导包括类风湿性关节炎和其它形式的炎症性关节炎，骨关节炎，假体衰竭，溶骨性肉瘤，骨髓瘤和肿瘤转移至骨骼的发病率与式I化合物， 也提供。

    INHIBITORS OF C-FMS KINASE
    8.
    发明申请
    INHIBITORS OF C-FMS KINASE 有权
    C-FMS激酶抑制剂

    公开(公告)号：US20090105296A1

    公开(公告)日：2009-04-23

    申请号：US12252439

    申请日：2008-10-16

    申请人： Carl R. Illig ,  Jinsheng Chen ,  Sanath K. Meegalia ,  Mark J. Wall

    发明人： Carl R. Illig ,  Jinsheng Chen ,  Sanath K. Meegalia ,  Mark J. Wall

    IPC分类号： A61K31/439 ,  C07D493/08 ,  C07D471/04 ,  A61K31/4439 ,  C07D405/14 ,  A61K31/4178

    CPC分类号： C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D471/08 ,  C07D493/08

    摘要： The invention is directed to compounds of Formula I: wherein Z, X, J, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, prostate cancer, lung cancer, colon cancer, stomach cancer, hairy cell leukemia; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including rheumatoid arthritis, and other forms of inflammatory arthritis, osteoarthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.

    摘要翻译： 本发明涉及式I化合物：其中Z，X，J，R 2和W在本说明书中列出，以及其抑制蛋白酪氨酸激酶，特别是c-型的溶剂化物，水合物，互变异构体和药学上可接受的盐， fms激酶。 治疗自身免疫性疾病的方法 和具有炎症成分的疾病; 治疗卵巢癌，子宫癌，乳腺癌，前列腺癌，肺癌，结肠癌，胃癌，毛细胞白血病的转移; 并治疗疼痛，包括由肿瘤转移或骨关节炎引起的骨骼疼痛，或内脏，炎症和神经源性疼痛; 骨质疏松症，佩吉特氏病和其他疾病，其中骨吸收介导包括类风湿性关节炎和其它形式的炎症性关节炎，骨关节炎，假体衰竭，溶骨性肉瘤，骨髓瘤和肿瘤转移至骨骼的发病率与式I化合物， 也提供。