公开(公告)号：US5320945A

公开(公告)日：1994-06-14

申请号：US122133

申请日：1993-09-15

申请人： Andreas Dessauer ,  Reinhard Herz ,  Helmut Lill

发明人： Andreas Dessauer ,  Reinhard Herz ,  Helmut Lill

IPC分类号： C12Q1/56

CPC分类号： C12Q1/56 ,  C12Q2337/12 ,  G01N2333/8128 ,  G01N2333/974

摘要： In order to determine antithrombin III in body fluids by reacting the sample with thrombin and a chromogenic substrate which forms a colour by the action of thrombin and measurement of the colour formed, the reaction is carried out in the presence of denaturing agents or of the tetrapeptide Gly-Pro-Arg-Pro and an oligopeptide is used as the substrate which has a sensitivity to thrombin which is a factor of 5 to 100-fold lower compared With Tos-Gly-Pro-Arg-pNA

摘要翻译： 为了通过使样品与凝血酶和形成色素的显色底物通过凝血酶的作用和形成的颜色的测量反应来确定体液中的抗凝血酶III，反应在变性剂或四肽的存在下进行 与Tos-Gly-Pro-Arg-pNA相比，Gly-Pro-Arg-Pro和寡肽用作对凝血酶敏感性为5至100倍的因子的底物

公开(公告)号：US5552296A

公开(公告)日：1996-09-03

申请号：US380184

申请日：1995-01-30

申请人： Enno Adema ,  Ulrike Gebert ,  Reinhard Herz

发明人： Enno Adema ,  Ulrike Gebert ,  Reinhard Herz

IPC分类号： C12Q1/56 ,  G01N33/86 ,  C12Q1/00 ,  G01N31/00 ,  G01N33/53

CPC分类号： C12Q1/56 ,  G01N33/86 ,  Y10S514/822 ,  Y10S514/834 ,  Y10T436/106664 ,  Y10T436/108331

摘要： In a method for the determination of coagulation parameters in sample material via a reaction cascade in which a thrombin-catalyzed formation of a fibrin clot from fibrin monomers occurs and the formation of the fibrin clot is measured, an inhibitor of F XIII is added. By this means the reaction vessel can be used several times for coagulation tests.

摘要翻译： 在通过反应级联测定样品材料中的凝血参数的方法中，其中发生凝血酶催化的来自纤维蛋白单体的纤维蛋白凝块的形成并测量纤维蛋白凝块的形成，加入F XIII的抑制剂。 通过这种方式，反应容器可以多次用于凝结试验。