公开(公告)号：US20050287137A1

公开(公告)日：2005-12-29

申请号：US11167872

申请日：2005-06-27

申请人： Patrick Dhaese ,  Pascal Mettens ,  Rene Meykens ,  Philippe Monteyne ,  Torbjorn Schiott ,  Leif Strandberg

发明人： Patrick Dhaese ,  Pascal Mettens ,  Rene Meykens ,  Philippe Monteyne ,  Torbjorn Schiott ,  Leif Strandberg

IPC分类号： A61K39/395 ,  C07K16/18 ,  C07K16/44

CPC分类号： C07K16/18 ,  C07K2317/622

摘要： The present invention relates to novel therapies and treatments of atherosclerotic diseases. Accordingly there is provided, methods of treating or preventing atherosclerosis by passive vaccination through administration to a patient of a fully human antibody that is capable of binding to the specific fragments of ApoCIII. Specific human monoclonal antibodies and their use in therapy of atherosclerosis is provided. There is further provided the use of the antibodies of the present invention in medicine.

摘要翻译： 本发明涉及动脉粥样硬化疾病的新疗法和治疗。 因此，提供了通过向能够结合到ApoCIII的特异性片段的完全人抗体的患者施用被动接种来治疗或预防动脉粥样硬化的方法。 提供特异性人单克隆抗体及其在治疗动脉粥样硬化中的应用。 还提供了本发明的抗体在医药中的用途。