公开(公告)号：US07446190B2

公开(公告)日：2008-11-04

申请号：US10448256

申请日：2003-05-28

申请人： Michel Sadelain ,  Renier Brentjens ,  John Maher

发明人： Michel Sadelain ,  Renier Brentjens ,  John Maher

IPC分类号： C07H21/04

CPC分类号： C07K16/2803 ,  A61K2039/505 ,  C07H21/04 ,  C07K14/7051 ,  C07K14/70521 ,  C07K16/3069 ,  C07K2319/00

摘要： Chimeric T cell receptors (TCR) are provided that combine, in a single chimeric species, the intracellular domain of CD3 ζ-chain, a signaling region from a costimulatory protein such as CD28, and a binding element that specifically interacts with a selected target. When expressed, for example in T-lymphocytes from the individual to be treated for a condition associated with the selected target, a T cell immune response is stimulated in the individual to the target cells. The chimeric TCR's are able to provide both the activation and the co-stimulation signals from a single molecule to more effectively direct T-lymphocyte cytotoxicity against the selected target and T-lymphocyte proliferation.

摘要翻译： 提供嵌合T细胞受体（TCR），其在单个嵌合物种中结合CD3zeta链的细胞内结构域，来自共刺激蛋白如CD28的信号传导区域，以及与选定靶标特异性相互作用的结合元件。 当表达时，例如来自待治疗个体的T淋巴细胞与所选择的靶标相关的病症，T细胞免疫应答在个体中被刺激到靶细胞。 嵌合TCR能够提供来自单个分子的活化和共刺激信号，以更有效地指导针对所选择的靶标和T淋巴细胞增殖的T淋巴细胞细胞毒性。