公开(公告)号：US5098841A

公开(公告)日：1992-03-24

申请号：US360802

申请日：1989-06-02

申请人： Oreste Ghisalba ,  Daniel Gygax ,  Rente Lattmann ,  Hans-Peter Schar ,  Elke Schmidt ,  Gottfried Sedelmeier

发明人： Oreste Ghisalba ,  Daniel Gygax ,  Rente Lattmann ,  Hans-Peter Schar ,  Elke Schmidt ,  Gottfried Sedelmeier

IPC分类号： C12P7/52 ,  C07C51/367 ,  C07K5/078 ,  C12P7/42 ,  C12R1/45

CPC分类号： C12P7/42 ,  C07C51/367 ,  C07K5/06139

摘要： The invention relates to a preferably continuous process for the preparation of R- or S-2-hydroxy-4-phenylbutyric acid in very high enantiomeric purity, which comprises reducing 2-oxo-4-phenylbutyric acid with the enzyme D-lactate dehydrogenase from Staphylococcus epidermidis or with the enzyme L-lactate dehydrogenase from bovine heart, respectively, in the presence of NAD(H) and formate or ethanol and formate dehydrogenase or alcohol dehydrogenase, respectively. R-2-hydroxy-4-phenylbutyric acid is a valuable intermediate in the preparation of ACE inhibitors or their precursors.

摘要翻译： 本发明涉及用于制备非常高对映体纯度的R-或S-2-羟基-4-苯基丁酸的优选连续方法，其包括用D-乳酸脱氢酶酶将2-氧代-4-苯基丁酸与 分别在NAD（H）和甲酸盐或乙醇和甲酸脱氢酶或醇脱氢酶存在下分别从牛心脏分泌表皮葡萄球菌或L-乳酸脱氢酶酶。 R-2-羟基-4-苯基丁酸是制备ACE抑制剂或其前体的有价值的中间体。