公开(公告)号：US06174540B1

公开(公告)日：2001-01-16

申请号：US09152775

申请日：1998-09-14

Applicant: James B. Williams ,  Rey T. Chern

Inventor： James B. Williams ,  Rey T. Chern

IPC: A61F202

CPC classification number: A61K31/7048 ,  A61K9/0019 ,  A61K47/14 ,  A61K47/44

Abstract: Long-acting injectable formulations are formed from a) a therapeutic agent selected from insecticides, acaricides, parasiticides, growth enhancers or oil-soluble NSAIDs, b) hydrogenated castor oil, and c) a hydrophobic carrier comprising i) triacetin, benzyl benzoate, ethyl oleate, or a combination thereof, and ii) acylated monoglycerides, propyl dicaprylates/dicaprates, caprylic/capric acid triglycerides or a combination thereof.

Abstract translation: 长效注射制剂由a）选自杀虫剂，杀螨剂，杀寄生虫剂，生长增强剂或油溶性非甾体类抗炎药的治疗剂形成，b）氢化蓖麻油，和c）疏水性载体，其包含i）三醋精，苯甲酸苄酯， 油酸酯或其组合，和ii）酰化单甘油酯，二辛酸丙酯/二癸酸酯，辛酸/癸酸甘油三酸酯或其组合。

公开(公告)号：US06733767B2

公开(公告)日：2004-05-11

申请号：US09271098

申请日：1999-03-18

Applicant: Rey T. Chern ,  Joel R. Zingerman

Inventor： Rey T. Chern ,  Joel R. Zingerman

IPC: A61K900

CPC classification number: A61K47/14 ,  A61K9/0024 ,  A61K47/34

Abstract: Controlled release of hydrophobic bioactive substances in vivo over an extended time period and without “bursts” of drug release is achieved using a liquid polymeric composition including a polymer such as poly(lactide-co-glycolide) copolymer in a mixture of hydrophilic and lipophilic solvents.

公开(公告)号：US20110240511A1

公开(公告)日：2011-10-06

申请号：US13139020

申请日：2009-12-02

Applicant: Matthew P. Bolton ,  Rey T. Chern ,  Arthur L. Jaeger ,  Matthew Moyer ,  Anthony P. Panarello

Inventor： Matthew P. Bolton ,  Rey T. Chern ,  Arthur L. Jaeger ,  Matthew Moyer ,  Anthony P. Panarello

IPC: B65D83/04

CPC classification number: B65D77/003 ,  A61J1/035 ,  B65D75/328 ,  B65D81/266 ,  B65D81/268 ,  B65D2205/00 ,  B65D2205/02

Abstract: The present invention relates to packaging and containers for oxygen-sensitive pharmaceutical products, or oxygen- and moisture-sensitive pharmaceutical products. More particularly, the invention relates to pharmaceutical packages comprising a blister pack with airflow channels and outlets, an oxygen scavenger, and, optionally, a desiccant, all of which are sealed inside an outer container having oxygen and moisture barrier properties.

Abstract translation: 本发明涉及用于氧敏感性药物产品或氧气和湿度敏感性药物产品的包装和容器。 更具体地，本发明涉及包括具有气流通道和出口的泡罩包装，除氧剂和任选的干燥剂的药物包装，所有这些都被密封在具有防氧化和防潮性的外部容器内。

公开(公告)号：US6136838A

公开(公告)日：2000-10-24

申请号：US271092

申请日：1999-03-18

Applicant: Rey T. Chern ,  Jeffrey N. Clark ,  Marlene D. Drag ,  Joel R. Zingerman

Inventor： Rey T. Chern ,  Jeffrey N. Clark ,  Marlene D. Drag ,  Joel R. Zingerman

IPC: A61K31/415 ,  A61K47/14 ,  A61K47/32

CPC classification number: A61K9/0019 ,  A61K31/415 ,  A61K47/14 ,  A61K47/32

Abstract: Sulfurpentafluorophenylpyrazoles of formula I are highly potent against flea and tick infestations in animals. The compounds may be formulated to provide products with long duration of action and low potential for inducing vomition and other adverse reactions in treated animals.

Abstract translation: 式I的五氟苯基吡唑对动物中的跳蚤和蜱虫侵袭具有高度的抗性。 可以将化合物配制成提供具有较长作用持续时间的产物和在治疗动物中诱导呕吐和其它不良反应的低潜力的产物。