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公开(公告)号：US20090075294A1
公开(公告)日：2009-03-19
申请号：US11703343
申请日：2007-02-06
IPC分类号： G01N33/53
CPC分类号： C07K14/43581
摘要： The present invention provides, for the first time, nucleic acids encoding a eukaryotic mechanosensory transduction channel (MSC) protein. The proteins encoded by these nucleic acids form channels that can directly detect mechanical stimuli and convert them into electrical signals. These nucleic acids and the proteins they encode can be used as probes for sensory cells in animals, and can be used to diagnose and treat any of a number of human conditions involving inherited, casual, or environmentally-induced loss of mechanosensory transduction activity.
摘要翻译： 本发明首次提供了编码真核机械感应通道（MSC）蛋白质的核酸。 由这些核酸编码的蛋白质形成可以直接检测机械刺激并将其转换为电信号的通道。 这些核酸及其编码的蛋白质可用作动物感觉细胞的探针，可用于诊断和治疗许多涉及遗传，休闲或环境诱导的机械感觉转导活性丧失的人类病症。
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公开(公告)号：US06537778B1
公开(公告)日：2003-03-25
申请号：US09392812
申请日：1999-09-09
IPC分类号： C12N1512
CPC分类号： C07K14/43581
摘要： The present invention provides, for the first time, nucleic acids encoding a eukaryotic mechanosensory transduction channel (MSC) protein. The proteins encoded by these nucleic acids form channels that can directly detect mechanical stimuli and convert them into electrical signals. These nucleic acids and the proteins they encode can be used as probes for sensory cells in animals, and can be used to diagnose and treat any of a number of human conditions involving inherited, casual, or environmentally-induced loss of mechanosensory transduction activity.
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3.发明授权In vitro method for identifying a compound using an eukaryotic mechanosensory transduction channel 有权使用真核机械感觉转导通道鉴定化合物的体外方法公开(公告)号：US07867721B2
公开(公告)日：2011-01-11
申请号：US11703343
申请日：2007-02-06
CPC分类号： C07K14/43581
摘要： The present invention provides, for the first time, nucleic acids encoding a eukaryotic mechanosensory transduction channel (MSC) protein. The proteins encoded by these nucleic acids form channels that can directly detect mechanical stimuli and convert them into electrical signals. These nucleic acids and the proteins they encode can be used as probes for sensory cells in animals, and can be used to diagnose and treat any of a number of human conditions involving inherited, casual, or environmentally-induced loss of mechanosensory transduction activity.
摘要翻译： 本发明首次提供了编码真核机械感应通道（MSC）蛋白质的核酸。 由这些核酸编码的蛋白质形成可以直接检测机械刺激并将其转换为电信号的通道。 这些核酸及其编码的蛋白质可用作动物感觉细胞的探针，可用于诊断和治疗许多涉及遗传，休闲或环境诱导的机械感觉转导活性丧失的人类病症。
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