公开(公告)号：US20060280684A1

公开(公告)日：2006-12-14

申请号：US10549204

申请日：2004-03-17

申请人： Riikka Lund ,  Zhi Chen ,  Riita Lahesmaa

发明人： Riikka Lund ,  Zhi Chen ,  Riita Lahesmaa

IPC分类号： A61K49/00 ,  C12Q1/68 ,  G01N33/567 ,  A61K39/395 ,  C07K14/74 ,  C07K16/28

CPC分类号： G01N33/564 ,  G01N33/5047 ,  G01N33/505

摘要： The present invention provides methods utilizing novel target genes related to immune-mediated diseases, such as asthma, allergy and autoimmune diseases. The invention is based on a molecular level description of the polarization of CD4+ precursor cells (Thp) from which T helper cells are known to originate. Particularly, the present invention provides a method of identifying a compound capable of modulating the polarization of CD4+ lymphocytes. The invention is also related to a method for assessing the presence of, or a predisposition to, an immune-related disorder in a subject.

摘要翻译： 本发明提供利用与免疫介导的疾病如哮喘，过敏和自身免疫疾病相关的新靶基因的方法。 本发明基于已知T辅助细胞来源的CD4 +前体细胞（Thp）的极化的分子水平描述。 特别地，本发明提供鉴定能够调节CD4 +淋巴细胞的极化的化合物的方法。 本发明还涉及用于评估受试者中免疫相关疾病的存在或倾向的方法。

公开(公告)号：US07989172B2

公开(公告)日：2011-08-02

申请号：US11662878

申请日：2005-09-16

申请人： Riikka Lund ,  Riitta Lahesmaa

发明人： Riikka Lund ,  Riitta Lahesmaa

IPC分类号： G01N33/53 ,  G01N33/567

CPC分类号： C12Q1/6881 ,  C12Q2600/136 ,  C12Q2600/158

摘要： The present invention provides methods utilizing novel target genes related to immune-mediated diseases, such as asthma, allergy and autoimmune diseases. The invention is based on a molecular level description of the polarization of CD4+ precursor cells (Thp) from which T helper cells are known to originate. Particularly, the present invention provides a method of identifying a compound capable of modulating the polarization of CD4+ lymphocytes. The invention is also related to a method for assessing the presence of, or disposition to, an immune-related disorder in a subject.

摘要翻译： 本发明提供利用与免疫介导的疾病如哮喘，过敏和自身免疫疾病相关的新靶基因的方法。 本发明基于已知T辅助细胞来源的CD4 +前体细胞（Thp）的极化的分子水平描述。 特别地，本发明提供鉴定能够调节CD4 +淋巴细胞的极化的化合物的方法。 本发明还涉及用于评估受试者中免疫相关疾病的存在或处置的方法。

公开(公告)号：US07659077B2

公开(公告)日：2010-02-09

申请号：US10549204

申请日：2004-03-17

申请人： Riikka Lund ,  Zhi Chen ,  Riitta Lahesmaa

发明人： Riikka Lund ,  Zhi Chen ,  Riitta Lahesmaa

IPC分类号： G01N33/53 ,  G01N33/567

CPC分类号： G01N33/564 ,  G01N33/5047 ,  G01N33/505

摘要： The present invention provides methods utilizing novel target genes related to immune-mediated diseases, such as asthma, allergy and autoimmune diseases. The invention is based on a molecular level description of the polarization of CD4+ precursor cells (Thp) from which T helper cells are known to originate. Particularly, the present invention provides a method of identifying a compound capable of modulating the polarization of CD4+ lymphocytes. The invention is also related to a method for assessing the presence of, or a predisposition to, an immune-related disorder in a subject.

摘要翻译： 本发明提供利用与免疫介导的疾病如哮喘，过敏和自身免疫疾病相关的新靶基因的方法。 本发明基于已知T辅助细胞来源的CD4 +前体细胞（Thp）的极化的分子水平描述。 特别地，本发明提供鉴定能够调节CD4 +淋巴细胞的极化的化合物的方法。 本发明还涉及用于评估受试者中免疫相关疾病的存在或倾向的方法。

公开(公告)号：US20080168570A1

公开(公告)日：2008-07-10

申请号：US11662878

申请日：2005-09-16

申请人： Riikka Lund ,  Riitta Lahesmaa

发明人： Riikka Lund ,  Riitta Lahesmaa

IPC分类号： A01K67/027 ,  C12Q1/68 ,  C12Q1/02

CPC分类号： C12Q1/6881 ,  C12Q2600/136 ,  C12Q2600/158

摘要： The present invention provides methods utilizing novel target genes related to immune-mediated diseases, such as asthma, allergy and autoimmune diseases. The invention is based on a molecular level description of the polarization of CD4+ precursor cells (Thp) from which T helper cells are known to originate. Particularly, the present invention provides a method of identifying a compound capable of modulating the polarization of CD4+ lymphocytes. The invention is also related to a method for assessing the presence of, or disposition to, an immune-related disorder in a subject.

摘要翻译： 本发明提供利用与免疫介导的疾病如哮喘，过敏和自身免疫疾病相关的新靶基因的方法。 本发明基于已知T辅助细胞来源的CD4 +前体细胞（Thp）的极化的分子水平描述。 特别地，本发明提供鉴定能够调节CD4 +淋巴细胞的极化的化合物的方法。 本发明还涉及用于评估受试者中免疫相关疾病的存在或处置的方法。