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公开(公告)号：US06670337B1
公开(公告)日：2003-12-30
申请号：US09363968
申请日：1999-07-29
IPC分类号： A01N4304
CPC分类号： A61K31/715 , A01N1/021
摘要： The method of the present invention provides a means for protecting a patient, including a transplant patient, from reperfusion injury by administering CM101 or GBS toxin isolated from Group B &bgr;-hemolytic Streptococcus bacteria. The present invention also includes a method to protect a tissue or organ against reperfusion injury in a transplant patient.
摘要翻译： 本发明的方法通过施用从B组溶血性链球菌细菌分离的CM101或GBS毒素，提供了一种保护包括移植患者在内的患者免受再灌注损伤的手段。 本发明还包括在移植患者中保护组织或器官免于再灌注损伤的方法。
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公开(公告)号：US06569838B1
公开(公告)日：2003-05-27
申请号：US09167774
申请日：1998-10-07
IPC分类号： A61K37715
CPC分类号： A61K31/715 , A01N1/0226
摘要： The present invention includes a means of treating a patient having a keloid. Specifically, the invention includes a method for excising the keloid and administering a GBS toxin isolated from Group B &bgr;-hemolytic Streptococcus bacteria.
摘要翻译： 本发明包括治疗患有瘢痕疙瘩的患者的方法。 具体地，本发明包括切除瘢痕疙瘩并施用从B组β-溶血性链球菌分离的GBS毒素的方法。
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公开(公告)号：US08304384B2
公开(公告)日：2012-11-06
申请号：US12306929
申请日：2007-06-27
申请人： David Wallach , Rinat Abramovitch , Eitan Galun , Tehila Ben Moshe , Hila Barash
发明人： David Wallach , Rinat Abramovitch , Eitan Galun , Tehila Ben Moshe , Hila Barash
IPC分类号： A61K38/16 , A61P31/04 , C07K14/435
CPC分类号： A61K38/4873 , A61K38/55 , C12N15/113 , C12N15/1135 , C12N2310/11 , C12Y304/22061 , Y02A50/409 , Y02A50/478 , Y02A50/481
摘要： The present invention relates to the regulatory role of caspase-8 in infection by intracellular pathogen, inflammation and wound healing.
摘要翻译： 本发明涉及胱天蛋白酶-8在细胞内病原体感染，炎症和伤口愈合中的调节作用。
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公开(公告)号：US5858991A
公开(公告)日：1999-01-12
申请号：US791763
申请日：1997-01-29
IPC分类号： A61K31/715 , A61K35/74 , A61P17/02 , A61P43/00 , A61K39/09
CPC分类号： A61K31/715 , A01N1/0226
摘要： The method of the present invention provides a means of treating a patient having a wound, especially by minimizing scarring and accelerating wound healing, by administering CM101 or GBS toxin isolated from Group B .beta.-hemolytic streptococcus bacteria. The method of the present invention also includes administration of CM101 or GBS toxin to surgery patients having tumors in order to facilitate wound healing and minimize the likelihood of tumor progression.
摘要翻译： 本发明的方法提供了通过施用从B组β-溶血性链球菌细菌分离的CM101或GBS毒素来治疗患有伤口的患者，特别是通过最小化瘢痕形成和加速伤口愈合的方法。 本发明的方法还包括将CM101或GBS毒素施用于具有肿瘤的手术患者，以便于伤口愈合并使肿瘤发展的可能性最小化。
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