公开(公告)号：US20060276376A1

公开(公告)日：2006-12-07

申请号：US11143885

申请日：2005-06-02

申请人： Kevin Campbell ,  Rita Barresi

发明人： Kevin Campbell ,  Rita Barresi

IPC分类号： A61K48/00 ,  A61K38/16

CPC分类号： C12N9/1048 ,  A61K38/1709 ,  A61K48/00 ,  C07K14/4707

摘要： Disclosed is a method for the prevention and/or treatment of muscle degeneration. In this method, a subject recognized as having muscle degeneration is treated with a composition effective to increase functional glycosylation of α-dystroglycan in an affected tissue in the subject. Functional glycosylation is to be increased to an extent wherein the binding of α-dystroglycan to its ligands in the affected tissue is rescued to levels substantially similar to those in an evenly matched tissue unaffected by degeneration. One effective means for increasing functional glycosylation of α-dystroglycan in a subject includes increasing glycosyltransferase activity, such as LARGE or LARGE2 activity, in the muscle of the subject. Therapeutic glycosylated peptide compositions are also provided.

摘要翻译： 公开了一种预防和/或治疗肌肉退化的方法。 在该方法中，被认为具有肌肉变性的受试者用有效增加受试者的受影响组织中α-依赖糖聚糖功能糖基化的组合物进行治疗。 功能性糖基化将被增加到其中α-dystroglylyc结合到受影响组织中的其配体的程度被拯救到基本上类似于不受退化影响的均匀匹配组织的水平。 用于增加受试者中α-谷胱甘肽聚糖功能糖基化的一种有效方法包括在受试者的肌肉中增加糖基转移酶活性，如LARGE或LARGE2活性。 还提供了治疗性糖基化肽组合物。

公开(公告)号：US08119766B2

公开(公告)日：2012-02-21

申请号：US11143885

申请日：2005-06-02

申请人： Kevin P. Campbell ,  Rita Barresi

发明人： Kevin P. Campbell ,  Rita Barresi

IPC分类号： C07K1/00 ,  C07H21/02 ,  C07H21/04 ,  A61K48/00

CPC分类号： C12N9/1048 ,  A61K38/1709 ,  A61K48/00 ,  C07K14/4707

摘要： Disclosed is a method for the prevention and/or treatment of muscle degeneration. In this method, a subject recognized as having muscle degeneration is treated with a composition effective to increase functional glycosylation of α-dystroglycan in an affected tissue in the subject. Functional glycosylation is to be increased to an extent wherein the binding of α-dystroglycan to its ligands in the affected tissue is rescued to levels substantially similar to those in an evenly matched tissue unaffected by degeneration. One effective means for increasing functional glycosylation of α-dystroglycan in a subject includes increasing glycosyltransferase activity, such as LARGE or LARGE2 activity, in the muscle of the subject. Therapeutic glycosylated peptide compositions are also provided.

摘要翻译： 公开了一种预防和/或治疗肌肉退化的方法。 在该方法中，被认为具有肌肉退化的受试者用有效增加受试者的受影响组织中α-肌浆聚糖功能性糖基化的组合物进行治疗。 功能性糖基化将被增加到其中α-dystroglylyc结合其受影响组织中的其配体的程度被挽救到基本上类似于不受退化影响的均匀匹配组织中的水平。 用于增加受试者中α-谷胱甘肽聚糖功能糖基化的一种有效方法包括在受试者的肌肉中增加糖基转移酶活性，如LARGE或LARGE2活性。 还提供了治疗性糖基化肽组合物。