公开(公告)号：US20070041947A1

公开(公告)日：2007-02-22

申请号：US11588965

申请日：2006-10-27

Applicant: Rob Barber ,  Mimoun Azzouz ,  Nicholas Mazarakis ,  Susan Kingsman

Inventor： Rob Barber ,  Mimoun Azzouz ,  Nicholas Mazarakis ,  Susan Kingsman

IPC: A61K48/00 ,  C12N15/867

CPC classification number: C12N15/86 ,  C12N2740/15043 ,  C12N2840/203

Abstract: Provided is a method for treating and/or preventing pain, in which a vector system is administered such that an EOI is delivered to a DRG of the subject. Also provided is a method for delivering an EOI to the spinal cord using such a vector system. Further provided is a method for identifying and/or validating an EOI by delivering a test EOI to target cell; analyzing the effect of the EOI on the target cell; and selecting an EOI with therapeutic potential. An EOI identified or validated by such a method, useful in the prevention and/or treatment of pain, is thereby provided as well.

Abstract translation: 提供了治疗和/或预防疼痛的方法，其中施用载体系统使得EOI被递送到受试者的DRG。 还提供了使用这种矢量系统将EOI递送到脊髓的方法。 还提供了通过将测试EOI递送到靶细胞来鉴定和/或验证EOI的方法; 分析EOI对靶细胞的影响; 并选择具有治疗潜力的EOI。 因此，也提供了通过这种方法鉴定或验证的用于预防和/或治疗疼痛的意向书（EOI）。