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    Use of a lentiviral vector in the treatment of pain
    1.
    发明申请
    Use of a lentiviral vector in the treatment of pain 审中-公开
    使用慢病毒载体治疗疼痛

    公开(公告)号：US20070041947A1

    公开(公告)日：2007-02-22

    申请号：US11588965

    申请日：2006-10-27

    Applicant: Rob Barber ,  Mimoun Azzouz ,  Nicholas Mazarakis ,  Susan Kingsman

    Inventor： Rob Barber ,  Mimoun Azzouz ,  Nicholas Mazarakis ,  Susan Kingsman

    IPC: A61K48/00 ,  C12N15/867

    CPC classification number: C12N15/86 ,  C12N2740/15043 ,  C12N2840/203

    Abstract: Provided is a method for treating and/or preventing pain, in which a vector system is administered such that an EOI is delivered to a DRG of the subject. Also provided is a method for delivering an EOI to the spinal cord using such a vector system. Further provided is a method for identifying and/or validating an EOI by delivering a test EOI to target cell; analyzing the effect of the EOI on the target cell; and selecting an EOI with therapeutic potential. An EOI identified or validated by such a method, useful in the prevention and/or treatment of pain, is thereby provided as well.

    Abstract translation: 提供了治疗和/或预防疼痛的方法，其中施用载体系统使得EOI被递送到受试者的DRG。 还提供了使用这种矢量系统将EOI递送到脊髓的方法。 还提供了通过将测试EOI递送到靶细胞来鉴定和/或验证EOI的方法; 分析EOI对靶细胞的影响; 并选择具有治疗潜力的EOI。 因此，也提供了通过这种方法鉴定或验证的用于预防和/或治疗疼痛的意向书（EOI）。

    Lentiviral-mediated growth factor gene therapy for neurodegenerative diseases
    2.
    发明授权
    Lentiviral-mediated growth factor gene therapy for neurodegenerative diseases 失效
    慢病毒介导的神经变性疾病生长因子基因治疗

    公开(公告)号：US06800281B2

    公开(公告)日：2004-10-05

    申请号：US10008610

    申请日：2001-11-08

    Applicant: Patrick Aebischer ,  Susan Mary Kingsman ,  Stuart Naylor ,  Nicholas Mazarakis

    Inventor： Patrick Aebischer ,  Susan Mary Kingsman ,  Stuart Naylor ,  Nicholas Mazarakis

    IPC: A61K4800

    CPC classification number: C12N15/86 ,  A61K48/00 ,  C07K14/4756 ,  C12N2740/15043

    Abstract: Disclosed and claimed are methods for treating or preventing neurodegenerative diseases, conditions or maladies or symptoms or physiology associated therewith, such as treating or preventing Parkinson's disease or symptoms or physiology associated therewith such as motor deficits or nigrostriatal degeneration; or, for inducing nigrostriatal regeneration. Advantageously, the methods involve administering a lentiviral vector that expresses GDNF, such as human GDNF, or a variant, homolog, analog or derivative thereof.

    Abstract translation: 公开并要求保护的是用于治疗或预防神经变性疾病，病症或疾病或症状或与之相关的生理学的方法，例如治疗或预防帕金森病或与之相关的症状或生理学，例如运动缺陷或黑质纹状体变性; 或用于诱导黑质纹状体再生。 有利地，所述方法包括施用表达GDNF的慢病毒载体，例如人GDNF，或其变体，同系物，类似物或衍生物。

    Vector system
    3.
    发明申请
    Vector system 审中-公开
    矢量系统

    公开(公告)号：US20070025970A1

    公开(公告)日：2007-02-01

    申请号：US11486914

    申请日：2006-07-14

    Applicant: Alan Kingsman ,  Nicholas Mazarakis ,  Enca Martin-Rendon ,  Mimoun Azzouz ,  Jonathan Rohll

    Inventor： Alan Kingsman ,  Nicholas Mazarakis ,  Enca Martin-Rendon ,  Mimoun Azzouz ,  Jonathan Rohll

    IPC: A61K48/00 ,  C12N15/867

    CPC classification number: C12N15/86 ,  A61K48/00 ,  C12N9/0071 ,  C12N2740/15043 ,  C12N2830/48 ,  C12N2840/206

    Abstract: The present invention relates to retroviral vector genomes and to vector systems comprising such genomes. In particular the present invention relates to a retroviral vector genome comprising two or more NOIs operably linked by one or more Internal Ribosome Entry Site(s); a lentiviral vector genome comprising two or more NOIs suitable for treating a neurodegenerative disorder; and a lentiviral vector genome which encodes tyrosine hydroxylase, GTP-cyclohydrolase I and optionally Aromatic Amino Acid Dopa Decarboxylase.

    Abstract translation: 本发明涉及逆转录病毒载体基因组以及包含这种基因组的载体系统。 特别地，本发明涉及包含两个或更多个通过一个或多个内部核糖体进入位点可操作地连接的NOI的逆转录病毒载体基因组; 包含两种或更多种适用于治疗神经变性疾病的NOI的慢病毒载体基因组; 和编码酪氨酸羟化酶，GTP-环化水解酶I和任选的芳香族氨基酸多巴脱羧酶的慢病毒载体基因组。

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