公开(公告)号：US4925856A

公开(公告)日：1990-05-15

申请号：US341489

申请日：1989-04-19

申请人： Ralph N. Harris, III ,  Clifford D. Bedford ,  Dane A. Goff ,  Duane E. Hilmas ,  Robert A. Howd ,  Richard A. Kenley ,  Gary A. Koolpe ,  Robert O. Pick

发明人： Ralph N. Harris, III ,  Clifford D. Bedford ,  Dane A. Goff ,  Duane E. Hilmas ,  Robert A. Howd ,  Richard A. Kenley ,  Gary A. Koolpe ,  Robert O. Pick

IPC分类号： C07D233/54 ,  C07D401/06

CPC分类号： C07D233/64 ,  C07D401/06

摘要： A therapeutically effective class of low toxicity aldoxime-substituted functionalized imidazolium compounds and compositions is disclosed which is effective in the treatment of living species poisoned by organophosphorus chemicals which inactivate the enzyme acetylcholinesterase. In vivo administration of therapeutically effective amounts of these aldoxime-substituted imidazolium derivatives has been found to save mammals having inhibited acetylcholinesterase due to injection with lethal dosages of Soman.

摘要翻译： 公开了一种治疗有效的低毒肟醛取代的官能化咪唑鎓化合物和组合物，其有效用于治疗由有效磷化学物质中毒的生物物质，其使酶乙酰胆碱酯酶失活。 已经发现体内施用治疗有效量的这些醛肟取代的咪唑衍生物可以节省由于Soman的致死剂量的注射而具有抑制的乙酰胆碱酯酶的哺乳动物。

公开(公告)号：US4865837A

公开(公告)日：1989-09-12

申请号：US78921

申请日：1987-07-28

申请人： Ralph N. Harris, III ,  Clifford D. Bedford ,  Duane E. Hilmas ,  Robert A. Howd ,  Richard A. Kenley ,  Gary A. Koolpe

发明人： Ralph N. Harris, III ,  Clifford D. Bedford ,  Duane E. Hilmas ,  Robert A. Howd ,  Richard A. Kenley ,  Gary A. Koolpe

IPC分类号： C07D249/08

CPC分类号： C07D249/08 ,  Y10S514/823

摘要： A therapeutically effective class of low toxicity aldoxime-substituted trazolium derivatives is disclosed which is effective in the treatment of living species poisoned by organophosphorus chemicals which inactivate the enzyme acetylcholinesterase. In vivo administration of therapeutically effective amounts of these low toxicity aldoxime-substituted triazolium derivatives has been found to save mice having inhibited acetylcholinesterase due to injection with lethal dosages of Soman.

摘要翻译： 公开了一种治疗有效的一类低毒阿肟肟取代的啮齿类衍生物，其有效用于治疗由有效磷化学物质中毒的生物物质，其使酶乙酰胆碱酯酶失活。 已经发现体内施用治疗有效量的这些低毒性的醛肟取代的三唑鎓衍生物可以节省由于Soman的致死剂量的注射而抑制的乙酰胆碱酯酶的小鼠。