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    Anti-allergy treatment using 2-(substituted amino)-4,5-dihydro-4-oxo-3-furancarboxylic acids and derivatives thereof
    2.
    发明授权
    Anti-allergy treatment using 2-(substituted amino)-4,5-dihydro-4-oxo-3-furancarboxylic acids and derivatives thereof 失效
    使用2-（取代的氨基）-4,5-二氢-4-氧代-3-呋喃羧酸及其衍生物的抗过敏治疗

    公开(公告)号：US4845122A

    公开(公告)日：1989-07-04

    申请号：US938305

    申请日：1986-12-05

    申请人： Vassil S. Georgiev ,  Clyde R. Kinsolving ,  Robert A. Mack

    发明人： Vassil S. Georgiev ,  Clyde R. Kinsolving ,  Robert A. Mack

    IPC分类号： A61K31/34

    CPC分类号： A61K31/34 ,  Y10S514/826

    摘要： As an anti-allergic treatment for warm-blooded animals, therapeutic amounts of a compound having the formula I (including acid salts thereof) or II are administered: ##STR1## where; R is OR.sup.4 or NHR.sup.5 in which R.sup.4 is hydrogen or lower alkyl, R.sup.5 is selected from phenyl and phenyl monosubstituted with halogen, lower alkyl, lower alkoxy, R.sup.1 and R.sup.2 are independently hydrogen or lower alkyl, andR.sup.3 is selected from lower alkyl, arylcyclopropyl, naphthyl, phenyl, and phenyl monosubstituted with lower alkyl, lower alkoxy, trifluoromethyl, halogen, nitro, carboxyl, or ethyl carboxylate; ##STR2## R.sup.6 is lower alkyl, R.sup.7 is selected from phenyl and phenyl monosubstituted with lower alkyl, lower alkoxy, halogen or acetyl, and M is an alkali or alkaline earth metal.

    摘要翻译： 作为对温血动物的抗过敏治疗，施用治疗量的具有式I化合物（包括其酸式盐）或II的化合物：其中： R是OR 4或NHR 5，其中R 4是氢或低级烷基，R 5选自苯基和被卤素，低级烷基，低级烷氧基单独取代的苯基，R 1和R 2独立地是氢或低级烷基，R 3选自低级烷基，芳基环丙基 萘基，苯基和被低级烷基，低级烷氧基，三氟甲基，卤素，硝基，羧基或羧酸乙酯单取代的苯基; R6是低级烷基，R7选自苯基和被低级烷基，低级烷氧基，卤素或乙酰基单取代的苯基，M是碱金属或碱土金属。

    N-(phenyl) or N-(phenylcyclopropyl)-2,5-dihydro-2-oxo-4[(substituted phenyl)amino]-3-furancarboxamide derivatives
    3.
    发明授权
    N-(phenyl) or N-(phenylcyclopropyl)-2,5-dihydro-2-oxo-4[(substituted phenyl)amino]-3-furancarboxamide derivatives 失效
    N-（苯基）或N-（苯基环丙基）-2,5-二氢-2-氧代-4 [（取代的苯基）氨基] -3-呋喃甲酰胺衍生物

    公开(公告)号：US4625040A

    公开(公告)日：1986-11-25

    申请号：US839298

    申请日：1986-03-13

    申请人： Vassil S. Georgiev ,  Robert A. Mack

    发明人： Vassil S. Georgiev ,  Robert A. Mack

    IPC分类号： C07D307/66 ,  A61K31/365 ,  A61P37/08 ,  C07D307/68

    CPC分类号： C07D307/68

    摘要： Compounds which possess antiallergy activity have the formula: ##STR1## wherein R is selected from phenyl and phenyl mono or disubstituted with lower alkyl, nitro, halogenated methyl, halogen, lower alkoxy and combinations thereof;wherein R.sup.1 is selected from hydrogen and lower alkyl; andwhere R.sup.2 is selected from phenyl, phenyl monosubstituted with lower alkyl, nitro, halogenated methyl, halogen, and lower alkoxy, and trans-phenylcyclopropyl in which the phenyl group may be substituted with lower alkyl or halogen.

    摘要翻译： 具有抗过敏活性的化合物具有下式：其中R选自苯基和被低级烷基，硝基，卤代甲基，卤素，低级烷氧基及其组合单取代或二取代的苯基; 其中R1选自氢和低级烷基; 并且其中R 2选自苯基，被低级烷基，硝基，卤代甲基，卤素和低级烷氧基单取代的苯基，以及苯基可被低级烷基或卤素取代的反式苯基环丙基。